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{{Infobox_gene}}
{{PBB_Controls
'''Target of Myb protein 1''' is a [[protein]] that in humans is encoded by the ''TOM1'' [[gene]].<ref name="pmid10329004">{{cite journal |vauthors=Seroussi E, Kedra D, Kost-Alimova M, Sandberg-Nordqvist AC, Fransson I, Jacobs JF, Fu Y, Pan HQ, Roe BA, Imreh S, Dumanski JP | title = TOM1 genes map to human chromosome 22q13.1 and mouse chromosome 8C1 and encode proteins similar to the endosomal proteins HGS and STAM | journal = Genomics | volume = 57 | issue = 3 | pages = 380–8 |date=Aug 1999 | pmid = 10329004 | pmc =  | doi = 10.1006/geno.1998.5739 }}</ref><ref name="pmid15047686">{{cite journal |vauthors=Katoh Y, Shiba Y, Mitsuhashi H, Yanagida Y, Takatsu H, Nakayama K | title = Tollip and Tom1 form a complex and recruit ubiquitin-conjugated proteins onto early endosomes | journal = J Biol Chem | volume = 279 | issue = 23 | pages = 24435–43 |date=May 2004 | pmid = 15047686 | pmc =  | doi = 10.1074/jbc.M400059200 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: TOM1 target of myb1 (chicken)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10043| accessdate = }}</ref>
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_TOM1_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1elk.
| PDB = {{PDB2|1elk}}, {{PDB2|1wrd}}
| Name = Target of myb1 (chicken)
| HGNCid = 11982
| Symbol = TOM1
| AltSymbols =; FLJ33404
| OMIM = 604700
| ECnumber =
| Homologene = 88453
| MGIid =
  | GeneAtlas_image1 = PBB_GE_TOM1_202807_s_at_tn.png
| Function = {{GNF_GO|id=GO:0005515 |text = protein binding}}  
| Component = {{GNF_GO|id=GO:0005622 |text = intracellular}} {{GNF_GO|id=GO:0005764 |text = lysosome}} {{GNF_GO|id=GO:0005768 |text = endosome}} {{GNF_GO|id=GO:0005769 |text = early endosome}} {{GNF_GO|id=GO:0005829 |text = cytosol}} {{GNF_GO|id=GO:0016020 |text = membrane}}
| Process = {{GNF_GO|id=GO:0006886 |text = intracellular protein transport}} {{GNF_GO|id=GO:0006897 |text = endocytosis}} {{GNF_GO|id=GO:0016197 |text = endosome transport}}
  | Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 10043
    | Hs_Ensembl = ENSG00000100284
    | Hs_RefseqProtein = NP_005479
    | Hs_RefseqmRNA = NM_005488
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 22
    | Hs_GenLoc_start = 34025845
    | Hs_GenLoc_end = 34073965
    | Hs_Uniprot = O60784
    | Mm_EntrezGene = 
    | Mm_Ensembl = 
    | Mm_RefseqmRNA = 
    | Mm_RefseqProtein = 
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 
    | Mm_GenLoc_start = 
    | Mm_GenLoc_end = 
    | Mm_Uniprot = 
  }}
}}
'''Target of myb1 (chicken)''', also known as '''TOM1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: TOM1 target of myb1 (chicken)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10043| accessdate = }}</ref>


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{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = The specific function of this gene has not yet been determined, yet it may involve the translocation of growth factor receptor complexes to the lysosome for degradation.  This gene is localized to 22q13.1, with HMOX1 and MCM5 distally and HMG2L1 proximally positioned.<ref name="entrez">{{cite web | title = Entrez Gene: TOM1 target of myb1 (chicken)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10043| accessdate = }}</ref>
| summary_text = The specific function of this gene has not yet been determined, yet it may involve the translocation of growth factor receptor complexes to the lysosome for degradation.  This gene is localized to 22q13.1, with HMOX1 and MCM5 distally and HMG2L1 proximally positioned.<ref name="entrez"/>
}}
}}
==Interactions==
TOM1 has been shown to [[Protein-protein interaction|interact]] with [[TOLLIP]]<ref name=pmid14563850>{{cite journal |last=Yamakami |first=Megumi |authorlink= |author2=Yoshimori Tamotsu |author3=Yokosawa Hideyoshi  |date=Dec 2003 |title=Tom1, a VHS domain-containing protein, interacts with tollip, ubiquitin, and clathrin |journal=J. Biol. Chem. |volume=278 |issue=52 |pages=52865–72 |publisher= |location = United States| issn = 0021-9258| pmid = 14563850 |doi = 10.1074/jbc.M306740200 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref> and [[ZFYVE16]].<ref name=pmid14613930>{{cite journal |last=Seet |first=Li-Fong |authorlink= |author2=Liu Ningsheng |author3=Hanson Brendon J |author4=Hong Wanjin  |date=Feb 2004 |title=Endofin recruits TOM1 to endosomes |journal=J. Biol. Chem. |volume=279 |issue=6 |pages=4670–9 |publisher= |location = United States| issn = 0021-9258| pmid = 14613930 |doi = 10.1074/jbc.M311228200 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref>


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal | author=Seroussi E, Kedra D, Kost-Alimova M, ''et al.'' |title=TOM1 genes map to human chromosome 22q13.1 and mouse chromosome 8C1 and encode proteins similar to the endosomal proteins HGS and STAM. |journal=Genomics |volume=57 |issue= 3 |pages= 380-8 |year= 1999 |pmid= 10329004 |doi= 10.1006/geno.1998.5739 }}
*{{cite journal   |vauthors=Dunham I, Shimizu N, Roe BA, etal |title=The DNA sequence of human chromosome 22. |journal=Nature |volume=402 |issue= 6761 |pages= 489–95 |year= 1999 |pmid= 10591208 |doi= 10.1038/990031 }}
*{{cite journal  | author=Dunham I, Shimizu N, Roe BA, ''et al.'' |title=The DNA sequence of human chromosome 22. |journal=Nature |volume=402 |issue= 6761 |pages= 489-95 |year= 1999 |pmid= 10591208 |doi= 10.1038/990031 }}
*{{cite journal  |vauthors=Misra S, Beach BM, Hurley JH |title=Structure of the VHS domain of human Tom1 (target of myb 1): insights into interactions with proteins and membranes. |journal=Biochemistry |volume=39 |issue= 37 |pages= 11282–90 |year= 2000 |pmid= 10985773 |doi=10.1021/bi0013546 }}
*{{cite journal  | author=Misra S, Beach BM, Hurley JH |title=Structure of the VHS domain of human Tom1 (target of myb 1): insights into interactions with proteins and membranes. |journal=Biochemistry |volume=39 |issue= 37 |pages= 11282-90 |year= 2000 |pmid= 10985773 |doi=  }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal   |vauthors=Clark HF, Gurney AL, Abaya E, etal |title=The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. |journal=Genome Res. |volume=13 |issue= 10 |pages= 2265–70 |year= 2003 |pmid= 12975309 |doi= 10.1101/gr.1293003 | pmc=403697 }}
*{{cite journal | author=Clark HF, Gurney AL, Abaya E, ''et al.'' |title=The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. |journal=Genome Res. |volume=13 |issue= 10 |pages= 2265-70 |year= 2003 |pmid= 12975309 |doi= 10.1101/gr.1293003 }}
*{{cite journal  |vauthors=Yamakami M, Yoshimori T, Yokosawa H |title=Tom1, a VHS domain-containing protein, interacts with tollip, ubiquitin, and clathrin. |journal=J. Biol. Chem. |volume=278 |issue= 52 |pages= 52865–72 |year= 2004 |pmid= 14563850 |doi= 10.1074/jbc.M306740200 }}
*{{cite journal  | author=Yamakami M, Yoshimori T, Yokosawa H |title=Tom1, a VHS domain-containing protein, interacts with tollip, ubiquitin, and clathrin. |journal=J. Biol. Chem. |volume=278 |issue= 52 |pages= 52865-72 |year= 2004 |pmid= 14563850 |doi= 10.1074/jbc.M306740200 }}
*{{cite journal  |vauthors=Seet LF, Liu N, Hanson BJ, Hong W |title=Endofin recruits TOM1 to endosomes. |journal=J. Biol. Chem. |volume=279 |issue= 6 |pages= 4670–9 |year= 2004 |pmid= 14613930 |doi= 10.1074/jbc.M311228200 }}
*{{cite journal  | author=Seet LF, Liu N, Hanson BJ, Hong W |title=Endofin recruits TOM1 to endosomes. |journal=J. Biol. Chem. |volume=279 |issue= 6 |pages= 4670-9 |year= 2004 |pmid= 14613930 |doi= 10.1074/jbc.M311228200 }}
*{{cite journal   |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal   |vauthors=Collins JE, Wright CL, Edwards CA, etal |title=A genome annotation-driven approach to cloning the human ORFeome. |journal=Genome Biol. |volume=5 |issue= 10 |pages= R84 |year= 2005 |pmid= 15461802 |doi= 10.1186/gb-2004-5-10-r84 | pmc=545604 }}
*{{cite journal | author=Katoh Y, Shiba Y, Mitsuhashi H, ''et al.'' |title=Tollip and Tom1 form a complex and recruit ubiquitin-conjugated proteins onto early endosomes. |journal=J. Biol. Chem. |volume=279 |issue= 23 |pages= 24435-43 |year= 2004 |pmid= 15047686 |doi= 10.1074/jbc.M400059200 }}
*{{cite journal  |vauthors=Seet LF, Hong W |title=Endofin recruits clathrin to early endosomes via TOM1. |journal=J. Cell Sci. |volume=118 |issue= Pt 3 |pages= 575–87 |year= 2005 |pmid= 15657082 |doi= 10.1242/jcs.01628 }}
*{{cite journal  | author=Collins JE, Wright CL, Edwards CA, ''et al.'' |title=A genome annotation-driven approach to cloning the human ORFeome. |journal=Genome Biol. |volume=5 |issue= 10 |pages= R84 |year= 2005 |pmid= 15461802 |doi= 10.1186/gb-2004-5-10-r84 }}
*{{cite journal   |vauthors=Schmid EM, Ford MG, Burtey A, etal |title=Role of the AP2 beta-appendage hub in recruiting partners for clathrin-coated vesicle assembly. |journal=PLoS Biol. |volume=4 |issue= 9 |pages= e262 |year= 2007 |pmid= 16903783 |doi= 10.1371/journal.pbio.0040262 | pmc=1540706 }}
*{{cite journal  | author=Seet LF, Hong W |title=Endofin recruits clathrin to early endosomes via TOM1. |journal=J. Cell. Sci. |volume=118 |issue= Pt 3 |pages= 575-87 |year= 2005 |pmid= 15657082 |doi= 10.1242/jcs.01628 }}
*{{cite journal   |vauthors=Olsen JV, Blagoev B, Gnad F, etal |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. |journal=Cell |volume=127 |issue= 3 |pages= 635–48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026 }}
*{{cite journal | author=Schmid EM, Ford MG, Burtey A, ''et al.'' |title=Role of the AP2 beta-appendage hub in recruiting partners for clathrin-coated vesicle assembly. |journal=PLoS Biol. |volume=4 |issue= 9 |pages= e262 |year= 2007 |pmid= 16903783 |doi= 10.1371/journal.pbio.0040262 }}
*{{cite journal | author=Olsen JV, Blagoev B, Gnad F, ''et al.'' |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. |journal=Cell |volume=127 |issue= 3 |pages= 635-48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026 }}
}}
}}
{{refend}}
{{refend}}
==External links==
* {{UCSC genome browser|TOM1}}
* {{UCSC gene details|TOM1}}
{{PDB Gallery|geneid=10043}}
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| update_page = yes
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| update_protein_box = yes
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{{WikiDoc Sources}}

Revision as of 21:01, 8 November 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Target of Myb protein 1 is a protein that in humans is encoded by the TOM1 gene.[1][2][3]

The specific function of this gene has not yet been determined, yet it may involve the translocation of growth factor receptor complexes to the lysosome for degradation. This gene is localized to 22q13.1, with HMOX1 and MCM5 distally and HMG2L1 proximally positioned.[3]

Interactions

TOM1 has been shown to interact with TOLLIP[4] and ZFYVE16.[5]

References

  1. ↑ Seroussi E, Kedra D, Kost-Alimova M, Sandberg-Nordqvist AC, Fransson I, Jacobs JF, Fu Y, Pan HQ, Roe BA, Imreh S, Dumanski JP (Aug 1999). "TOM1 genes map to human chromosome 22q13.1 and mouse chromosome 8C1 and encode proteins similar to the endosomal proteins HGS and STAM". Genomics. 57 (3): 380–8. doi:10.1006/geno.1998.5739. PMID 10329004.
  2. ↑ Katoh Y, Shiba Y, Mitsuhashi H, Yanagida Y, Takatsu H, Nakayama K (May 2004). "Tollip and Tom1 form a complex and recruit ubiquitin-conjugated proteins onto early endosomes". J Biol Chem. 279 (23): 24435–43. doi:10.1074/jbc.M400059200. PMID 15047686.
  3. ↑ 3.0 3.1 "Entrez Gene: TOM1 target of myb1 (chicken)".
  4. ↑ Yamakami, Megumi; Yoshimori Tamotsu; Yokosawa Hideyoshi (Dec 2003). "Tom1, a VHS domain-containing protein, interacts with tollip, ubiquitin, and clathrin". J. Biol. Chem. United States. 278 (52): 52865–72. doi:10.1074/jbc.M306740200. ISSN 0021-9258. PMID 14563850.
  5. ↑ Seet, Li-Fong; Liu Ningsheng; Hanson Brendon J; Hong Wanjin (Feb 2004). "Endofin recruits TOM1 to endosomes". J. Biol. Chem. United States. 279 (6): 4670–9. doi:10.1074/jbc.M311228200. ISSN 0021-9258. PMID 14613930.

Further reading

External links



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