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<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''Tumor protein D53''' is a [[protein]] that in humans is encoded by the ''TPD52L1'' [[gene]].<ref name="pmid8812487">{{cite journal | vauthors = Byrne JA, Mattei MG, Basset P | title = Definition of the tumor protein D52 (TPD52) gene family through cloning of D52 homologues in human (hD53) and mouse (mD52) | journal = Genomics | volume = 35 | issue = 3 | pages = 523–32  | date = Dec 1996 | pmid = 8812487 | pmc =  | doi = 10.1006/geno.1996.0393 }}</ref><ref name="pmid16112108">{{cite journal | vauthors = Boutros R, Byrne JA | title = D53 (TPD52L1) is a cell cycle-regulated protein maximally expressed at the G2-M transition in breast cancer cells | journal = Exp. Cell Res. | volume = 310 | issue = 1 | pages = 152–65  | date = Oct 2005 | pmid = 16112108 | pmc =  | doi = 10.1016/j.yexcr.2005.07.009 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: TPD52L1 tumor protein D52-like 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7164| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Tumor protein D52-like 1
| HGNCid = 12006
| Symbol = TPD52L1
| AltSymbols =; D53; MGC8556; TPD52L2; hD53
| OMIM = 604069
| ECnumber = 
| Homologene = 2468
| MGIid = 1298386
| GeneAtlas_image1 = PBB_GE_TPD52L1_210372_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_TPD52L1_203786_s_at_tn.png
| Function = {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0008656 |text = caspase activator activity}} {{GNF_GO|id=GO:0042803 |text = protein homodimerization activity}} {{GNF_GO|id=GO:0046982 |text = protein heterodimerization activity}}
| Component = {{GNF_GO|id=GO:0005737 |text = cytoplasm}} {{GNF_GO|id=GO:0048471 |text = perinuclear region of cytoplasm}}
| Process = {{GNF_GO|id=GO:0000086 |text = G2/M transition of mitotic cell cycle}} {{GNF_GO|id=GO:0006309 |text = DNA fragmentation during apoptosis}} {{GNF_GO|id=GO:0006917 |text = induction of apoptosis}} {{GNF_GO|id=GO:0043406 |text = positive regulation of MAPK activity}} {{GNF_GO|id=GO:0046330 |text = positive regulation of JNK cascade}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 7164
    | Hs_Ensembl = ENSG00000111907
    | Hs_RefseqProtein = NP_001003395
    | Hs_RefseqmRNA = NM_001003395
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 6
    | Hs_GenLoc_start = 125516578
    | Hs_GenLoc_end = 125627252
    | Hs_Uniprot = Q16890
    | Mm_EntrezGene = 21987
    | Mm_Ensembl = ENSMUSG00000000296
    | Mm_RefseqmRNA = NM_009413
    | Mm_RefseqProtein = NP_033439
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 10
    | Mm_GenLoc_start = 31022257
    | Mm_GenLoc_end = 31068765
    | Mm_Uniprot = Q3V2G6
  }}
}}
'''Tumor protein D52-like 1''', also known as '''TPD52L1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: TPD52L1 tumor protein D52-like 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7164| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
This gene encodes a member of the tumor protein D52 (TPD52) family. The encoded protein contains a coiled-coil domain and may form homo- or hetero-dimer with TPD52 family members. The protein is reported to be involved in cell proliferation and calcium signaling. It also interacts with the mitogen-activated protein kinase kinase kinase 5 (MAP3K5/ASK1) and positively regulates MAP3K5-induced apoptosis. Multiple alternatively spliced transcript variants have been observed, but the full-length nature of some variants has not yet been determined.<ref name="entrez" />
{{PBB_Summary
| section_title =
| summary_text = This gene encodes a member of the tumor protein D52 (TPD52) family. The encoded protein contains a coiled-coil domain and may form homo- or hetero-dimer with TPD52 family members. The protein is reported to be involved in cell proliferation and calcium signaling. It also interacts with the mitogen-activated protein kinase kinase kinase 5 (MAP3K5/ASK1) and positively regulates MAP3K5-induced apoptosis. Multiple alternatively spliced transcript variants have been observed, but the full-length nature of some variants has not yet been determined.<ref name="entrez">{{cite web | title = Entrez Gene: TPD52L1 tumor protein D52-like 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7164| accessdate = }}</ref>
}}


==References==
== Interactions ==
{{reflist|2}}
 
==Further reading==
TPD52L1 has been shown to [[Protein-protein interaction|interact]] with [[TPD52L2]]<ref name=pmid9484778>{{cite journal | vauthors = Byrne JA, Nourse CR, Basset P, Gunning P | title = Identification of homo- and heteromeric interactions between members of the breast carcinoma-associated D52 protein family using the yeast two-hybrid system | journal = Oncogene | volume = 16 | issue = 7 | pages = 873–81  | date = Feb 1998 | pmid = 9484778 | doi = 10.1038/sj.onc.1201604 }}</ref> and [[TPD52]].<ref name=pmid9484778/>
 
== References ==
{{reflist}}
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Byrne JA, Tomasetto C, Garnier JM, Rouyer N, Mattei MG, Bellocq JP, Rio MC, Basset P | title = A screening method to identify genes commonly overexpressed in carcinomas and the identification of a novel complementary DNA sequence | journal = Cancer Res. | volume = 55 | issue = 13 | pages = 2896–903 | year = 1995 | pmid = 7796418 | doi =  }}
| citations =
* {{cite journal | vauthors = Byrne JA, Nourse CR, Basset P, Gunning P | title = Identification of homo- and heteromeric interactions between members of the breast carcinoma-associated D52 protein family using the yeast two-hybrid system | journal = Oncogene | volume = 16 | issue = 7 | pages = 873–81 | year = 1998 | pmid = 9484778 | doi = 10.1038/sj.onc.1201604 }}
*{{cite journal | author=Byrne JA, Tomasetto C, Garnier JM, ''et al.'' |title=A screening method to identify genes commonly overexpressed in carcinomas and the identification of a novel complementary DNA sequence. |journal=Cancer Res. |volume=55 |issue= 13 |pages= 2896-903 |year= 1995 |pmid= 7796418 |doi=  }}
* {{cite journal | vauthors = Byrne JA, Mattei MG, Basset P, Gunning P | title = Identification and in situ hybridization mapping of a mouse Tpd52l1 (D53) orthologue to chromosome 10A4-B2 | journal = Cytogenet. Cell Genet. | volume = 81 | issue = 3-4 | pages = 199–201 | year = 1998 | pmid = 9730602 | doi = 10.1159/000015029 }}
*{{cite journal | author=Byrne JA, Mattei MG, Basset P |title=Definition of the tumor protein D52 (TPD52) gene family through cloning of D52 homologues in human (hD53) and mouse (mD52). |journal=Genomics |volume=35 |issue= 3 |pages= 523-32 |year= 1996 |pmid= 8812487 |doi= 10.1006/geno.1996.0393 }}
* {{cite journal | vauthors = Wilson SH, Bailey AM, Nourse CR, Mattei MG, Byrne JA | title = Identification of MAL2, a novel member of the mal proteolipid family, though interactions with TPD52-like proteins in the yeast two-hybrid system | journal = Genomics | volume = 76 | issue = 1-3 | pages = 81–8 | year = 2001 | pmid = 11549320 | doi = 10.1006/geno.2001.6610 }}
*{{cite journal  | author=Byrne JA, Nourse CR, Basset P, Gunning P |title=Identification of homo- and heteromeric interactions between members of the breast carcinoma-associated D52 protein family using the yeast two-hybrid system. |journal=Oncogene |volume=16 |issue= 7 |pages= 873-81 |year= 1998 |pmid= 9484778 |doi= 10.1038/sj.onc.1201604 }}
* {{cite journal | vauthors = Sathasivam P, Bailey AM, Crossley M, Byrne JA | title = The role of the coiled-coil motif in interactions mediated by TPD52 | journal = Biochem. Biophys. Res. Commun. | volume = 288 | issue = 1 | pages = 56–61 | year = 2001 | pmid = 11594751 | doi = 10.1006/bbrc.2001.5721 }}
*{{cite journal | author=Byrne JA, Mattei MG, Basset P, Gunning P |title=Identification and in situ hybridization mapping of a mouse Tpd52l1 (D53) orthologue to chromosome 10A4-B2. |journal=Cytogenet. Cell Genet. |volume=81 |issue= 3-4 |pages= 199-201 |year= 1998 |pmid= 9730602 |doi= }}
* {{cite journal | vauthors = Boutros R, Bailey AM, Wilson SH, Byrne JA | title = Alternative splicing as a mechanism for regulating 14-3-3 binding: interactions between hD53 (TPD52L1) and 14-3-3 proteins | journal = J. Mol. Biol. | volume = 332 | issue = 3 | pages = 675–87 | year = 2003 | pmid = 12963375 | doi = 10.1016/S0022-2836(03)00944-6 }}
*{{cite journal | author=Wilson SH, Bailey AM, Nourse CR, ''et al.'' |title=Identification of MAL2, a novel member of the mal proteolipid family, though interactions with TPD52-like proteins in the yeast two-hybrid system. |journal=Genomics |volume=76 |issue= 1-3 |pages= 81-8 |year= 2001 |pmid= 11549320 |doi= 10.1006/geno.2001.6610 }}
* {{cite journal | vauthors = Cho S, Ko HM, Kim JM, Lee JA, Park JE, Jang MS, Park SG, Lee DH, Ryu SE, Park BC | title = Positive regulation of apoptosis signal-regulating kinase 1 by hD53L1 | journal = J. Biol. Chem. | volume = 279 | issue = 16 | pages = 16050–6 | year = 2004 | pmid = 14761963 | doi = 10.1074/jbc.M305758200 }}
*{{cite journal | author=Sathasivam P, Bailey AM, Crossley M, Byrne JA |title=The role of the coiled-coil motif in interactions mediated by TPD52. |journal=Biochem. Biophys. Res. Commun. |volume=288 |issue= 1 |pages= 56-61 |year= 2001 |pmid= 11594751 |doi= 10.1006/bbrc.2001.5721 }}
* {{cite journal | vauthors = Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M | title = Towards a proteome-scale map of the human protein-protein interaction network | journal = Nature | volume = 437 | issue = 7062 | pages = 1173–8 | year = 2005 | pmid = 16189514 | doi = 10.1038/nature04209 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
* {{cite journal | vauthors = Barbaric D, Byth K, Dalla-Pozza L, Byrne JA | title = Expression of tumor protein D52-like genes in childhood leukemia at diagnosis: clinical and sample considerations | journal = Leuk. Res. | volume = 30 | issue = 11 | pages = 1355–63 | year = 2006 | pmid = 16620967 | doi = 10.1016/j.leukres.2006.03.009 }}
*{{cite journal  | author=Boutros R, Bailey AM, Wilson SH, Byrne JA |title=Alternative splicing as a mechanism for regulating 14-3-3 binding: interactions between hD53 (TPD52L1) and 14-3-3 proteins. |journal=J. Mol. Biol. |volume=332 |issue= 3 |pages= 675-87 |year= 2003 |pmid= 12963375 |doi= }}
* {{cite journal | vauthors = Cao Q, Chen J, Zhu L, Liu Y, Zhou Z, Sha J, Wang S, Li J | title = A testis-specific and testis developmentally regulated tumor protein D52 (TPD52)-like protein TPD52L3/hD55 interacts with TPD52 family proteins | journal = Biochem. Biophys. Res. Commun. | volume = 344 | issue = 3 | pages = 798–806 | year = 2006 | pmid = 16631610 | doi = 10.1016/j.bbrc.2006.03.208 }}
*{{cite journal  | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal | author=Cho S, Ko HM, Kim JM, ''et al.'' |title=Positive regulation of apoptosis signal-regulating kinase 1 by hD53L1. |journal=J. Biol. Chem. |volume=279 |issue= 16 |pages= 16050-6 |year= 2004 |pmid= 14761963 |doi= 10.1074/jbc.M305758200 }}
*{{cite journal | author=Boutros R, Byrne JA |title=D53 (TPD52L1) is a cell cycle-regulated protein maximally expressed at the G2-M transition in breast cancer cells. |journal=Exp. Cell Res. |volume=310 |issue= 1 |pages= 152-65 |year= 2005 |pmid= 16112108 |doi= 10.1016/j.yexcr.2005.07.009 }}
*{{cite journal  | author=Rual JF, Venkatesan K, Hao T, ''et al.'' |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173-8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
*{{cite journal | author=Barbaric D, Byth K, Dalla-Pozza L, Byrne JA |title=Expression of tumor protein D52-like genes in childhood leukemia at diagnosis: clinical and sample considerations. |journal=Leuk. Res. |volume=30 |issue= 11 |pages= 1355-63 |year= 2007 |pmid= 16620967 |doi= 10.1016/j.leukres.2006.03.009 }}
*{{cite journal | author=Cao Q, Chen J, Zhu L, ''et al.'' |title=A testis-specific and testis developmentally regulated tumor protein D52 (TPD52)-like protein TPD52L3/hD55 interacts with TPD52 family proteins. |journal=Biochem. Biophys. Res. Commun. |volume=344 |issue= 3 |pages= 798-806 |year= 2006 |pmid= 16631610 |doi= 10.1016/j.bbrc.2006.03.208 }}
}}
{{refend}}
{{refend}}


{{protein-stub}}
 
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Latest revision as of 02:42, 27 October 2017

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

n/a

n/a

Ensembl

n/a

n/a

UniProt

n/a

n/a

RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Tumor protein D53 is a protein that in humans is encoded by the TPD52L1 gene.[1][2][3]

Function

This gene encodes a member of the tumor protein D52 (TPD52) family. The encoded protein contains a coiled-coil domain and may form homo- or hetero-dimer with TPD52 family members. The protein is reported to be involved in cell proliferation and calcium signaling. It also interacts with the mitogen-activated protein kinase kinase kinase 5 (MAP3K5/ASK1) and positively regulates MAP3K5-induced apoptosis. Multiple alternatively spliced transcript variants have been observed, but the full-length nature of some variants has not yet been determined.[3]

Interactions

TPD52L1 has been shown to interact with TPD52L2[4] and TPD52.[4]

References

  1. ↑ Byrne JA, Mattei MG, Basset P (Dec 1996). "Definition of the tumor protein D52 (TPD52) gene family through cloning of D52 homologues in human (hD53) and mouse (mD52)". Genomics. 35 (3): 523–32. doi:10.1006/geno.1996.0393. PMID 8812487.
  2. ↑ Boutros R, Byrne JA (Oct 2005). "D53 (TPD52L1) is a cell cycle-regulated protein maximally expressed at the G2-M transition in breast cancer cells". Exp. Cell Res. 310 (1): 152–65. doi:10.1016/j.yexcr.2005.07.009. PMID 16112108.
  3. ↑ 3.0 3.1 "Entrez Gene: TPD52L1 tumor protein D52-like 1".
  4. ↑ 4.0 4.1 Byrne JA, Nourse CR, Basset P, Gunning P (Feb 1998). "Identification of homo- and heteromeric interactions between members of the breast carcinoma-associated D52 protein family using the yeast two-hybrid system". Oncogene. 16 (7): 873–81. doi:10.1038/sj.onc.1201604. PMID 9484778.

Further reading

  • Byrne JA, Tomasetto C, Garnier JM, Rouyer N, Mattei MG, Bellocq JP, Rio MC, Basset P (1995). "A screening method to identify genes commonly overexpressed in carcinomas and the identification of a novel complementary DNA sequence". Cancer Res. 55 (13): 2896–903. PMID 7796418.
  • Byrne JA, Nourse CR, Basset P, Gunning P (1998). "Identification of homo- and heteromeric interactions between members of the breast carcinoma-associated D52 protein family using the yeast two-hybrid system". Oncogene. 16 (7): 873–81. doi:10.1038/sj.onc.1201604. PMID 9484778.
  • Byrne JA, Mattei MG, Basset P, Gunning P (1998). "Identification and in situ hybridization mapping of a mouse Tpd52l1 (D53) orthologue to chromosome 10A4-B2". Cytogenet. Cell Genet. 81 (3–4): 199–201. doi:10.1159/000015029. PMID 9730602.
  • Wilson SH, Bailey AM, Nourse CR, Mattei MG, Byrne JA (2001). "Identification of MAL2, a novel member of the mal proteolipid family, though interactions with TPD52-like proteins in the yeast two-hybrid system". Genomics. 76 (1–3): 81–8. doi:10.1006/geno.2001.6610. PMID 11549320.
  • Sathasivam P, Bailey AM, Crossley M, Byrne JA (2001). "The role of the coiled-coil motif in interactions mediated by TPD52". Biochem. Biophys. Res. Commun. 288 (1): 56–61. doi:10.1006/bbrc.2001.5721. PMID 11594751.
  • Boutros R, Bailey AM, Wilson SH, Byrne JA (2003). "Alternative splicing as a mechanism for regulating 14-3-3 binding: interactions between hD53 (TPD52L1) and 14-3-3 proteins". J. Mol. Biol. 332 (3): 675–87. doi:10.1016/S0022-2836(03)00944-6. PMID 12963375.
  • Cho S, Ko HM, Kim JM, Lee JA, Park JE, Jang MS, Park SG, Lee DH, Ryu SE, Park BC (2004). "Positive regulation of apoptosis signal-regulating kinase 1 by hD53L1". J. Biol. Chem. 279 (16): 16050–6. doi:10.1074/jbc.M305758200. PMID 14761963.
  • Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
  • Barbaric D, Byth K, Dalla-Pozza L, Byrne JA (2006). "Expression of tumor protein D52-like genes in childhood leukemia at diagnosis: clinical and sample considerations". Leuk. Res. 30 (11): 1355–63. doi:10.1016/j.leukres.2006.03.009. PMID 16620967.
  • Cao Q, Chen J, Zhu L, Liu Y, Zhou Z, Sha J, Wang S, Li J (2006). "A testis-specific and testis developmentally regulated tumor protein D52 (TPD52)-like protein TPD52L3/hD55 interacts with TPD52 family proteins". Biochem. Biophys. Res. Commun. 344 (3): 798–806. doi:10.1016/j.bbrc.2006.03.208. PMID 16631610.


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