TRIM23: Difference between revisions

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{{Infobox_gene}}
{{PBB_Controls
'''GTP-binding protein ARD-1''' is a [[protein]] that in humans is encoded by the ''TRIM23'' [[gene]].<ref name="pmid8473324">{{cite journal | vauthors = Mishima K, Tsuchiya M, Nightingale MS, Moss J, Vaughan M | title = ARD 1, a 64-kDa guanine nucleotide-binding protein with a carboxyl-terminal ADP-ribosylation factor domain | journal = The Journal of Biological Chemistry | volume = 268 | issue = 12 | pages = 8801–7 | date = Apr 1993 | pmid = 8473324 | pmc =  | doi =  }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: TRIM23 tripartite motif-containing 23| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=373| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Tripartite motif-containing 23
| HGNCid = 660
| Symbol = TRIM23
| AltSymbols =; ARD1; ARFD1; RNF46
| OMIM = 601747
| ECnumber = 
| Homologene = 1251
| MGIid = 1933161
| GeneAtlas_image1 = PBB_GE_TRIM23_204732_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_TRIM23_210994_x_at_tn.png
| GeneAtlas_image3 = PBB_GE_TRIM23_210995_s_at_tn.png
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0003924 |text = GTPase activity}} {{GNF_GO|id=GO:0004842 |text = ubiquitin-protein ligase activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0005525 |text = GTP binding}} {{GNF_GO|id=GO:0008047 |text = enzyme activator activity}} {{GNF_GO|id=GO:0008270 |text = zinc ion binding}} {{GNF_GO|id=GO:0019003 |text = GDP binding}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}}
| Component = {{GNF_GO|id=GO:0000139 |text = Golgi membrane}} {{GNF_GO|id=GO:0005622 |text = intracellular}} {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005737 |text = cytoplasm}} {{GNF_GO|id=GO:0005765 |text = lysosomal membrane}}
| Process = {{GNF_GO|id=GO:0007264 |text = small GTPase mediated signal transduction}} {{GNF_GO|id=GO:0016567 |text = protein ubiquitination}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 373
    | Hs_Ensembl = ENSG00000113595
    | Hs_RefseqProtein = NP_001647
    | Hs_RefseqmRNA = NM_001656
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 5
    | Hs_GenLoc_start = 64921263
    | Hs_GenLoc_end = 64956199
    | Hs_Uniprot = P36406
    | Mm_EntrezGene = 81003
    | Mm_Ensembl = ENSMUSG00000021712
    | Mm_RefseqmRNA = NM_030731
    | Mm_RefseqProtein = NP_109656
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 13
    | Mm_GenLoc_start = 105299209
    | Mm_GenLoc_end = 105323857
    | Mm_Uniprot = Q99PN1
  }}
}}
'''Tripartite motif-containing 23''', also known as '''TRIM23''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: TRIM23 tripartite motif-containing 23| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=373| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein is also a member of the ADP ribosylation factor family of guanine nucleotide-binding family of proteins. Its carboxy terminus contains an ADP-ribosylation factor domain and a guanine nucleotide binding site, while the amino terminus contains a GTPase activating protein domain which acts on the guanine nucleotide binding site. The protein localizes to lysosomes and the Golgi apparatus. It plays a role in the formation of intracellular transport vesicles, their movement from one compartment to another, and [[phospholipase D]] activation. Three alternatively spliced transcript variants for this gene have been described.<ref name="entrez" />
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein is also a member of the ADP ribosylation factor family of guanine nucleotide-binding family of proteins. Its carboxy terminus contains an ADP-ribosylation factor domain and a guanine nucleotide binding site, while the amino terminus contains a GTPase activating protein domain which acts on the guanine nucleotide binding site. The protein localizes to lysosomes and the Golgi apparatus. It plays a role in the formation of intracellular transport vesicles, their movement from one compartment to another, and phopholipase D activation. Three alternatively spliced transcript variants for this gene have been described.<ref name="entrez">{{cite web | title = Entrez Gene: TRIM23 tripartite motif-containing 23| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=373| accessdate = }}</ref>
}}


==References==
== Interactions ==
{{reflist|2}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal  | author=Mishima K, Tsuchiya M, Nightingale MS, ''et al.'' |title=ARD 1, a 64-kDa guanine nucleotide-binding protein with a carboxyl-terminal ADP-ribosylation factor domain. |journal=J. Biol. Chem. |volume=268 |issue= 12 |pages= 8801-7 |year= 1993 |pmid= 8473324 |doi=  }}
*{{cite journal  | author=Vitale N, Moss J, Vaughan M |title=ARD1, a 64-kDa bifunctional protein containing an 18-kDa GTP-binding ADP-ribosylation factor domain and a 46-kDa GTPase-activating domain. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=93 |issue= 5 |pages= 1941-4 |year= 1996 |pmid= 8700863 |doi=  }}
*{{cite journal  | author=Vitale N, Moss J, Vaughan M |title=Characterization of a GDP dissociation inhibitory region of ADP-ribosylation factor domain protein ARD1. |journal=J. Biol. Chem. |volume=272 |issue= 40 |pages= 25077-82 |year= 1997 |pmid= 9312116 |doi=  }}
*{{cite journal  | author=Vitale N, Moss J, Vaughan M |title=Molecular characterization of the GTPase-activating domain of ADP-ribosylation factor domain protein 1 (ARD1). |journal=J. Biol. Chem. |volume=273 |issue= 5 |pages= 2553-60 |year= 1998 |pmid= 9446556 |doi=  }}
*{{cite journal  | author=Vitale N, Horiba K, Ferrans VJ, ''et al.'' |title=Localization of ADP-ribosylation factor domain protein 1 (ARD1) in lysosomes and Golgi apparatus. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=95 |issue= 15 |pages= 8613-8 |year= 1998 |pmid= 9671726 |doi=  }}
*{{cite journal  | author=Vitale N, Pacheco-Rodriguez G, Ferrans VJ, ''et al.'' |title=Specific functional interaction of human cytohesin-1 and ADP-ribosylation factor domain protein (ARD1). |journal=J. Biol. Chem. |volume=275 |issue= 28 |pages= 21331-9 |year= 2000 |pmid= 10748148 |doi= 10.1074/jbc.M909642199 }}
*{{cite journal  | author=Vitale N, Ferrans VJ, Moss J, Vaughan M |title=Identification of lysosomal and Golgi localization signals in GAP and ARF domains of ARF domain protein 1. |journal=Mol. Cell. Biol. |volume=20 |issue= 19 |pages= 7342-52 |year= 2000 |pmid= 10982851 |doi=  }}
*{{cite journal  | author=Reymond A, Meroni G, Fantozzi A, ''et al.'' |title=The tripartite motif family identifies cell compartments. |journal=EMBO J. |volume=20 |issue= 9 |pages= 2140-51 |year= 2001 |pmid= 11331580 |doi= 10.1093/emboj/20.9.2140 }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | author=Vichi A, Payne DM, Pacheco-Rodriguez G, ''et al.'' |title=E3 ubiquitin ligase activity of the trifunctional ARD1 (ADP-ribosylation factor domain protein 1). |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=102 |issue= 6 |pages= 1945-50 |year= 2005 |pmid= 15684077 |doi= 10.1073/pnas.0409800102 }}
*{{cite journal  | author=Rual JF, Venkatesan K, Hao T, ''et al.'' |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173-8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
}}
{{refend}}


{{protein-stub}}
TRIM23 has been shown to [[Protein-protein interaction|interact]] with [[TRIM31]],<ref name=pmid11331580>{{cite journal | vauthors = Reymond A, Meroni G, Fantozzi A, Merla G, Cairo S, Luzi L, Riganelli D, Zanaria E, Messali S, Cainarca S, Guffanti A, Minucci S, Pelicci PG, Ballabio A | title = The tripartite motif family identifies cell compartments | journal = The EMBO Journal | volume = 20 | issue = 9 | pages = 2140–51 | date = May 2001 | pmid = 11331580 | pmc = 125245 | doi = 10.1093/emboj/20.9.2140 }}</ref> [[TRIM29]]<ref name=pmid11331580/> and [[PSCD1]].<ref name=pmid10748148>{{cite journal | vauthors = Vitale N, Pacheco-Rodriguez G, Ferrans VJ, Riemenschneider W, Moss J, Vaughan M | title = Specific functional interaction of human cytohesin-1 and ADP-ribosylation factor domain protein (ARD1) | journal = The Journal of Biological Chemistry | volume = 275 | issue = 28 | pages = 21331–9 | date = Jul 2000 | pmid = 10748148 | doi = 10.1074/jbc.M909642199 }}</ref>
{{WikiDoc Sources}}
 
== References ==
{{Reflist}}
 
== Further reading ==
{{Refbegin | 2}}
* {{cite journal | vauthors = Vitale N, Moss J, Vaughan M | title = ARD1, a 64-kDa bifunctional protein containing an 18-kDa GTP-binding ADP-ribosylation factor domain and a 46-kDa GTPase-activating domain | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 93 | issue = 5 | pages = 1941–4 | date = Mar 1996 | pmid = 8700863 | pmc = 39887 | doi = 10.1073/pnas.93.5.1941 }}
* {{cite journal | vauthors = Vitale N, Moss J, Vaughan M | title = Characterization of a GDP dissociation inhibitory region of ADP-ribosylation factor domain protein ARD1 | journal = The Journal of Biological Chemistry | volume = 272 | issue = 40 | pages = 25077–82 | date = Oct 1997 | pmid = 9312116 | doi = 10.1074/jbc.272.40.25077 }}
* {{cite journal | vauthors = Vitale N, Moss J, Vaughan M | title = Molecular characterization of the GTPase-activating domain of ADP-ribosylation factor domain protein 1 (ARD1) | journal = The Journal of Biological Chemistry | volume = 273 | issue = 5 | pages = 2553–60 | date = Jan 1998 | pmid = 9446556 | doi = 10.1074/jbc.273.5.2553 }}
* {{cite journal | vauthors = Vitale N, Horiba K, Ferrans VJ, Moss J, Vaughan M | title = Localization of ADP-ribosylation factor domain protein 1 (ARD1) in lysosomes and Golgi apparatus | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 95 | issue = 15 | pages = 8613–8 | date = Jul 1998 | pmid = 9671726 | pmc = 21124 | doi = 10.1073/pnas.95.15.8613 }}
* {{cite journal | vauthors = Vitale N, Pacheco-Rodriguez G, Ferrans VJ, Riemenschneider W, Moss J, Vaughan M | title = Specific functional interaction of human cytohesin-1 and ADP-ribosylation factor domain protein (ARD1) | journal = The Journal of Biological Chemistry | volume = 275 | issue = 28 | pages = 21331–9 | date = Jul 2000 | pmid = 10748148 | doi = 10.1074/jbc.M909642199 }}
* {{cite journal | vauthors = Vitale N, Ferrans VJ, Moss J, Vaughan M | title = Identification of lysosomal and Golgi localization signals in GAP and ARF domains of ARF domain protein 1 | journal = Molecular and Cellular Biology | volume = 20 | issue = 19 | pages = 7342–52 | date = Oct 2000 | pmid = 10982851 | pmc = 86288 | doi = 10.1128/MCB.20.19.7342-7352.2000 }}
* {{cite journal | vauthors = Reymond A, Meroni G, Fantozzi A, Merla G, Cairo S, Luzi L, Riganelli D, Zanaria E, Messali S, Cainarca S, Guffanti A, Minucci S, Pelicci PG, Ballabio A | title = The tripartite motif family identifies cell compartments | journal = The EMBO Journal | volume = 20 | issue = 9 | pages = 2140–51 | date = May 2001 | pmid = 11331580 | pmc = 125245 | doi = 10.1093/emboj/20.9.2140 }}
* {{cite journal | vauthors = Vichi A, Payne DM, Pacheco-Rodriguez G, Moss J, Vaughan M | title = E3 ubiquitin ligase activity of the trifunctional ARD1 (ADP-ribosylation factor domain protein 1) | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 102 | issue = 6 | pages = 1945–50 | date = Feb 2005 | pmid = 15684077 | pmc = 548593 | doi = 10.1073/pnas.0409800102 }}
{{Refend}}
 
{{Gene-5-stub}}

Latest revision as of 12:16, 15 September 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
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Wikidata
View/Edit Human

GTP-binding protein ARD-1 is a protein that in humans is encoded by the TRIM23 gene.[1][2]

Function

The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein is also a member of the ADP ribosylation factor family of guanine nucleotide-binding family of proteins. Its carboxy terminus contains an ADP-ribosylation factor domain and a guanine nucleotide binding site, while the amino terminus contains a GTPase activating protein domain which acts on the guanine nucleotide binding site. The protein localizes to lysosomes and the Golgi apparatus. It plays a role in the formation of intracellular transport vesicles, their movement from one compartment to another, and phospholipase D activation. Three alternatively spliced transcript variants for this gene have been described.[2]

Interactions

TRIM23 has been shown to interact with TRIM31,[3] TRIM29[3] and PSCD1.[4]

References

  1. ↑ Mishima K, Tsuchiya M, Nightingale MS, Moss J, Vaughan M (Apr 1993). "ARD 1, a 64-kDa guanine nucleotide-binding protein with a carboxyl-terminal ADP-ribosylation factor domain". The Journal of Biological Chemistry. 268 (12): 8801–7. PMID 8473324.
  2. ↑ 2.0 2.1 "Entrez Gene: TRIM23 tripartite motif-containing 23".
  3. ↑ 3.0 3.1 Reymond A, Meroni G, Fantozzi A, Merla G, Cairo S, Luzi L, Riganelli D, Zanaria E, Messali S, Cainarca S, Guffanti A, Minucci S, Pelicci PG, Ballabio A (May 2001). "The tripartite motif family identifies cell compartments". The EMBO Journal. 20 (9): 2140–51. doi:10.1093/emboj/20.9.2140. PMC 125245. PMID 11331580.
  4. ↑ Vitale N, Pacheco-Rodriguez G, Ferrans VJ, Riemenschneider W, Moss J, Vaughan M (Jul 2000). "Specific functional interaction of human cytohesin-1 and ADP-ribosylation factor domain protein (ARD1)". The Journal of Biological Chemistry. 275 (28): 21331–9. doi:10.1074/jbc.M909642199. PMID 10748148.

Further reading

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