TRIM63: Difference between revisions
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{{ | '''E3 ubiquitin-protein ligase TRIM63''' is an [[enzyme]] that in humans is encoded by the ''TRIM63'' [[gene]].<ref name="pmid11243782">{{cite journal | vauthors = Centner T, Yano J, Kimura E, McElhinny AS, Pelin K, Witt CC, Bang ML, Trombitas K, Granzier H, Gregorio CC, Sorimachi H, Labeit S | title = Identification of muscle specific ring finger proteins as potential regulators of the titin kinase domain | journal = J Mol Biol | volume = 306 | issue = 4 | pages = 717–26 |date=Mar 2001 | pmid = 11243782 | pmc = | doi = 10.1006/jmbi.2001.4448 }}</ref><ref name="pmid11283016">{{cite journal | vauthors = Dai KS, Liew CC | title = A novel human striated muscle RING zinc finger protein, SMRZ, interacts with SMT3b via its RING domain | journal = J Biol Chem | volume = 276 | issue = 26 | pages = 23992–9 |date=Jun 2001 | pmid = 11283016 | pmc = | doi = 10.1074/jbc.M011208200 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: TRIM63 tripartite motif-containing 63| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=84676| accessdate = }}</ref> | ||
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| summary_text = This gene encodes a member of the RING zinc finger protein family found in striated muscle and iris. The product of this gene is localized to the Z-line and M-line lattices of myofibrils, where titin's N-terminal and C-terminal regions respectively bind to the sarcomere. In vitro binding studies have shown that this protein also binds directly to titin near the region of titin containing kinase activity. Another member of this protein family binds to microtubules. Since these family members can form heterodimers, this suggests that these proteins may serve as a link between titin kinase and microtubule-dependent signal pathways in muscle.<ref name="entrez" | | summary_text = This gene encodes a member of the RING zinc finger protein family found in striated muscle and iris. The product of this gene is localized to the Z-line and M-line lattices of myofibrils, where titin's N-terminal and C-terminal regions respectively bind to the sarcomere. In vitro binding studies have shown that this protein also binds directly to titin near the region of titin containing kinase activity. Another member of this protein family binds to microtubules. Since these family members can form heterodimers, this suggests that these proteins may serve as a link between titin kinase and microtubule-dependent signal pathways in muscle.<ref name="entrez" /> | ||
}} | }} | ||
==Interactions== | |||
TRIM63 has been shown to [[Protein-protein interaction|interact]] with [[Titin]],<ref name=pmid11243782 /> [[GMEB1]]<ref name=pmid11927605>{{cite journal |vauthors=McElhinny AS, Kakinuma K, Sorimachi H, Labeit S, Gregorio CC |title=Muscle-specific RING finger-1 interacts with titin to regulate sarcomeric M-line and thick filament structure and may have nuclear functions via its interaction with glucocorticoid modulatory element binding protein-1 |journal=J. Cell Biol. |volume=157 |issue=1 |pages=125–36 |date=April 2002 |pmid=11927605 |pmc=2173255 |doi=10.1083/jcb.200108089 |url=}}</ref> and [[SUMO2]].<ref name=pmid11283016 /> | |||
==References== | ==References== | ||
{{reflist | {{reflist}} | ||
==Further reading== | ==Further reading== | ||
{{refbegin | 2}} | {{refbegin | 2}} | ||
{{PBB_Further_reading | {{PBB_Further_reading | ||
| citations = | | citations = | ||
*{{cite journal | *{{cite journal |vauthors=Bodine SC, Latres E, Baumhueter S, etal |title=Identification of ubiquitin ligases required for skeletal muscle atrophy. |journal=Science |volume=294 |issue= 5547 |pages= 1704–8 |year= 2001 |pmid= 11679633 |doi= 10.1126/science.1065874 }} | ||
*{{cite journal |vauthors=McElhinny AS, Kakinuma K, Sorimachi H, etal |title=Muscle-specific RING finger-1 interacts with titin to regulate sarcomeric M-line and thick filament structure and may have nuclear functions via its interaction with glucocorticoid modulatory element binding protein-1. |journal=J. Cell Biol. |volume=157 |issue= 1 |pages= 125–36 |year= 2002 |pmid= 11927605 |doi= 10.1083/jcb.200108089 | pmc=2173255 }} | |||
*{{cite journal |vauthors=Wistow G, Bernstein SL, Ray S, etal |title=Expressed sequence tag analysis of adult human iris for the NEIBank Project: steroid-response factors and similarities with retinal pigment epithelium. |journal=Mol. Vis. |volume=8 |issue= |pages= 185–95 |year= 2002 |pmid= 12107412 |doi= }} | |||
*{{cite journal | *{{cite journal |vauthors=Pizon V, Iakovenko A, Van Der Ven PF, etal |title=Transient association of titin and myosin with microtubules in nascent myofibrils directed by the MURF2 RING-finger protein. |journal=J. Cell Sci. |volume=115 |issue= Pt 23 |pages= 4469–82 |year= 2003 |pmid= 12414993 |doi=10.1242/jcs.00131 }} | ||
*{{cite journal | *{{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }} | ||
*{{cite journal | *{{cite journal |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }} | ||
*{{cite journal | *{{cite journal |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }} | ||
*{{cite journal | *{{cite journal |vauthors=Kedar V, McDonough H, Arya R, etal |title=Muscle-specific RING finger 1 is a bona fide ubiquitin ligase that degrades cardiac troponin I. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 52 |pages= 18135–40 |year= 2005 |pmid= 15601779 |doi= 10.1073/pnas.0404341102 | pmc=539735 }} | ||
*{{cite journal | *{{cite journal | vauthors=Witt SH, Granzier H, Witt CC, Labeit S |title=MURF-1 and MURF-2 target a specific subset of myofibrillar proteins redundantly: towards understanding MURF-dependent muscle ubiquitination. |journal=J. Mol. Biol. |volume=350 |issue= 4 |pages= 713–22 |year= 2005 |pmid= 15967462 |doi= 10.1016/j.jmb.2005.05.021 }} | ||
*{{cite journal | *{{cite journal |vauthors=Gregory SG, Barlow KF, McLay KE, etal |title=The DNA sequence and biological annotation of human chromosome 1. |journal=Nature |volume=441 |issue= 7091 |pages= 315–21 |year= 2006 |pmid= 16710414 |doi= 10.1038/nature04727 }} | ||
*{{cite journal | | *{{cite journal |vauthors=Doucet M, Russell AP, Léger B, etal |title=Muscle atrophy and hypertrophy signaling in patients with chronic obstructive pulmonary disease. |journal=Am. J. Respir. Crit. Care Med. |volume=176 |issue= 3 |pages= 261–9 |year= 2007 |pmid= 17478621 |doi= 10.1164/rccm.200605-704OC }} | ||
*{{cite journal | |||
*{{cite journal | |||
}} | }} | ||
{{refend}} | {{refend}} | ||
{{PDB Gallery|geneid=84676}} | |||
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Species | Human | Mouse | |||||
Entrez |
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Location (UCSC) | n/a | n/a | |||||
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E3 ubiquitin-protein ligase TRIM63 is an enzyme that in humans is encoded by the TRIM63 gene.[1][2][3]
This gene encodes a member of the RING zinc finger protein family found in striated muscle and iris. The product of this gene is localized to the Z-line and M-line lattices of myofibrils, where titin's N-terminal and C-terminal regions respectively bind to the sarcomere. In vitro binding studies have shown that this protein also binds directly to titin near the region of titin containing kinase activity. Another member of this protein family binds to microtubules. Since these family members can form heterodimers, this suggests that these proteins may serve as a link between titin kinase and microtubule-dependent signal pathways in muscle.[3]
Interactions
TRIM63 has been shown to interact with Titin,[1] GMEB1[4] and SUMO2.[2]
References
- ↑ 1.0 1.1 Centner T, Yano J, Kimura E, McElhinny AS, Pelin K, Witt CC, Bang ML, Trombitas K, Granzier H, Gregorio CC, Sorimachi H, Labeit S (Mar 2001). "Identification of muscle specific ring finger proteins as potential regulators of the titin kinase domain". J Mol Biol. 306 (4): 717–26. doi:10.1006/jmbi.2001.4448. PMID 11243782.
- ↑ 2.0 2.1 Dai KS, Liew CC (Jun 2001). "A novel human striated muscle RING zinc finger protein, SMRZ, interacts with SMT3b via its RING domain". J Biol Chem. 276 (26): 23992–9. doi:10.1074/jbc.M011208200. PMID 11283016.
- ↑ 3.0 3.1 "Entrez Gene: TRIM63 tripartite motif-containing 63".
- ↑ McElhinny AS, Kakinuma K, Sorimachi H, Labeit S, Gregorio CC (April 2002). "Muscle-specific RING finger-1 interacts with titin to regulate sarcomeric M-line and thick filament structure and may have nuclear functions via its interaction with glucocorticoid modulatory element binding protein-1". J. Cell Biol. 157 (1): 125–36. doi:10.1083/jcb.200108089. PMC 2173255. PMID 11927605.
Further reading
- Bodine SC, Latres E, Baumhueter S, et al. (2001). "Identification of ubiquitin ligases required for skeletal muscle atrophy". Science. 294 (5547): 1704–8. doi:10.1126/science.1065874. PMID 11679633.
- McElhinny AS, Kakinuma K, Sorimachi H, et al. (2002). "Muscle-specific RING finger-1 interacts with titin to regulate sarcomeric M-line and thick filament structure and may have nuclear functions via its interaction with glucocorticoid modulatory element binding protein-1". J. Cell Biol. 157 (1): 125–36. doi:10.1083/jcb.200108089. PMC 2173255. PMID 11927605.
- Wistow G, Bernstein SL, Ray S, et al. (2002). "Expressed sequence tag analysis of adult human iris for the NEIBank Project: steroid-response factors and similarities with retinal pigment epithelium". Mol. Vis. 8: 185–95. PMID 12107412.
- Pizon V, Iakovenko A, Van Der Ven PF, et al. (2003). "Transient association of titin and myosin with microtubules in nascent myofibrils directed by the MURF2 RING-finger protein". J. Cell Sci. 115 (Pt 23): 4469–82. doi:10.1242/jcs.00131. PMID 12414993.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Kedar V, McDonough H, Arya R, et al. (2005). "Muscle-specific RING finger 1 is a bona fide ubiquitin ligase that degrades cardiac troponin I." Proc. Natl. Acad. Sci. U.S.A. 101 (52): 18135–40. doi:10.1073/pnas.0404341102. PMC 539735. PMID 15601779.
- Witt SH, Granzier H, Witt CC, Labeit S (2005). "MURF-1 and MURF-2 target a specific subset of myofibrillar proteins redundantly: towards understanding MURF-dependent muscle ubiquitination". J. Mol. Biol. 350 (4): 713–22. doi:10.1016/j.jmb.2005.05.021. PMID 15967462.
- Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. doi:10.1038/nature04727. PMID 16710414.
- Doucet M, Russell AP, Léger B, et al. (2007). "Muscle atrophy and hypertrophy signaling in patients with chronic obstructive pulmonary disease". Am. J. Respir. Crit. Care Med. 176 (3): 261–9. doi:10.1164/rccm.200605-704OC. PMID 17478621.
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