TRNT1: Difference between revisions

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{{Infobox_gene}}
{{PBB_Controls
'''tRNA-nucleotidyltransferase 1,''' is an [[enzyme]] that in humans is encoded by the ''TRNT1'' [[gene]].<ref name="pmid10810093">{{cite journal |vauthors=Lai CH, Chou CY, Ch'ang LY, Liu CS, Lin W | title = Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics | journal = Genome Res | volume = 10 | issue = 5 | pages = 703–13 |date=Aug 2000 | pmid = 10810093 | pmc = 310876 | doi =10.1101/gr.10.5.703 }}</ref><ref name="pmid11504732">{{cite journal |vauthors=Nagaike T, Suzuki T, Tomari Y, Takemoto-Hori C, Negayama F, Watanabe K, Ueda T | title = Identification and characterization of mammalian mitochondrial tRNA nucleotidyltransferases | journal = J Biol Chem | volume = 276 | issue = 43 | pages = 40041–9 |date=Oct 2001 | pmid = 11504732 | pmc =  | doi = 10.1074/jbc.M106202200 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: TRNT1 tRNA nucleotidyl transferase, CCA-adding, 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=51095| accessdate = }}</ref>
| update_page = yes
This enzyme adds the nucleotide sequence CCA to the 3' end of [[tRNA]], using [[adenosine triphosphate|ATP]] and [[cytidine triphosphate|CTP]] as substrates. The sequence creates the binding site for an amino acid.<ref>{{cite journal |vauthors=Lizano E, Scheibe M, Rammelt C, Betat H, Mörl M |title=A comparative analysis of CCA-adding enzymes from human and E. coli: differences in CCA addition and tRNA 3'-end repair |journal=Biochimie |volume=90 |issue=5 |pages=762–72 |date=May 2008 |pmid=18226598 |doi=10.1016/j.biochi.2007.12.007}}</ref>
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{{GNF_Protein_box
| image = PBB_Protein_TRNT1_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1ou5.
| PDB = {{PDB2|1ou5}}
| Name = TRNA nucleotidyl transferase, CCA-adding, 1
| HGNCid = 17341
| Symbol = TRNT1
| AltSymbols =; CCA1; CGI-47; MtCCA
| OMIM =
| ECnumber =
| Homologene = 9333
| MGIid = 1917297
| Function = {{GNF_GO|id=GO:0000049 |text = tRNA binding}} {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0000287 |text = magnesium ion binding}} {{GNF_GO|id=GO:0004810 |text = tRNA adenylyltransferase activity}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0016740 |text = transferase activity}}
  | Component = {{GNF_GO|id=GO:0005622 |text = intracellular}} {{GNF_GO|id=GO:0005739 |text = mitochondrion}}
| Process = {{GNF_GO|id=GO:0006626 |text = protein targeting to mitochondrion}} {{GNF_GO|id=GO:0042780 |text = tRNA 3'-processing}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 51095
    | Hs_Ensembl = ENSG00000072756
    | Hs_RefseqProtein = NP_057084
    | Hs_RefseqmRNA = NM_016000
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 3
    | Hs_GenLoc_start = 3143620
    | Hs_GenLoc_end = 3167542
    | Hs_Uniprot = Q96Q11
    | Mm_EntrezGene = 70047
    | Mm_Ensembl = ENSMUSG00000013736
    | Mm_RefseqmRNA = NM_027296
    | Mm_RefseqProtein = NP_081572
    | Mm_GenLoc_db =   
    | Mm_GenLoc_chr = 6
    | Mm_GenLoc_start = 106734949
    | Mm_GenLoc_end = 106748246
    | Mm_Uniprot = Q8K1J6
  }}
}}
'''TRNA nucleotidyl transferase, CCA-adding, 1''', also known as '''TRNT1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: TRNT1 tRNA nucleotidyl transferase, CCA-adding, 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=51095| accessdate = }}</ref>


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==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Lai CH, Chou CY, Ch'ang LY, ''et al.'' |title=Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. |journal=Genome Res. |volume=10 |issue= 5 |pages= 703-13 |year= 2000 |pmid= 10810093 |doi=  }}
*{{cite journal  |vauthors=Hartley JL, Temple GF, Brasch MA |title=DNA cloning using in vitro site-specific recombination |journal=Genome Res. |volume=10 |issue= 11 |pages= 1788–95 |year= 2001 |pmid= 11076863 |doi=10.1101/gr.143000  | pmc=310948 }}
*{{cite journal  | author=Hartley JL, Temple GF, Brasch MA |title=DNA cloning using in vitro site-specific recombination. |journal=Genome Res. |volume=10 |issue= 11 |pages= 1788-95 |year= 2001 |pmid= 11076863 |doi=  }}
*{{cite journal  | author=Wiemann S |title=Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs |journal=Genome Res. |volume=11 |issue= 3 |pages= 422–35 |year= 2001 |pmid= 11230166 |doi= 10.1101/gr.GR1547R  | pmc=311072  |name-list-format=vanc| author2=Weil B  | author3=Wellenreuther R  | display-authors=3  | last4=Gassenhuber  | first4=J  | last5=Glassl  | first5=S  | last6=Ansorge  | first6=W  | last7=Böcher  | first7=M  | last8=Blöcker  | first8=H  | last9=Bauersachs  | first9=S }}
*{{cite journal  | author=Wiemann S, Weil B, Wellenreuther R, ''et al.'' |title=Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. |journal=Genome Res. |volume=11 |issue= 3 |pages= 422-35 |year= 2001 |pmid= 11230166 |doi= 10.1101/gr.154701 }}
*{{cite journal  | author=Simpson JC |title=Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing |journal=EMBO Rep. |volume=1 |issue= 3 |pages= 287–92 |year= 2001 |pmid= 11256614 |doi= 10.1093/embo-reports/kvd058  | pmc=1083732  |name-list-format=vanc| author2=Wellenreuther R  | author3=Poustka A  | display-authors=3  | last4=Pepperkok  | first4=R  | last5=Wiemann  | first5=S }}
*{{cite journal  | author=Simpson JC, Wellenreuther R, Poustka A, ''et al.'' |title=Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing. |journal=EMBO Rep. |volume=1 |issue= 3 |pages= 287-92 |year= 2001 |pmid= 11256614 |doi= 10.1093/embo-reports/kvd058 }}
*{{cite journal  |vauthors=Reichert AS, Thurlow DL, Mörl M |title=A eubacterial origin for the human tRNA nucleotidyltransferase? |journal=Biol. Chem. |volume=382 |issue= 10 |pages= 1431–8 |year= 2002 |pmid= 11727826 |doi=10.1515/BC.2001.176 }}
*{{cite journal | author=Nagaike T, Suzuki T, Tomari Y, ''et al.'' |title=Identification and characterization of mammalian mitochondrial tRNA nucleotidyltransferases. |journal=J. Biol. Chem. |volume=276 |issue= 43 |pages= 40041-9 |year= 2001 |pmid= 11504732 |doi= 10.1074/jbc.M106202200 }}
*{{cite journal  | author=Strausberg RL |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241  |name-list-format=vanc| author2=Feingold EA  | author3=Grouse LH  | display-authors=3  | last4=Derge  | first4=JG  | last5=Klausner  | first5=RD  | last6=Collins  | first6=FS  | last7=Wagner  | first7=L  | last8=Shenmen  | first8=CM  | last9=Schuler  | first9=GD }}
*{{cite journal  | author=Reichert AS, Thurlow DL, Mörl M |title=A eubacterial origin for the human tRNA nucleotidyltransferase? |journal=Biol. Chem. |volume=382 |issue= 10 |pages= 1431-8 |year= 2002 |pmid= 11727826 |doi=  }}
*{{cite journal  | author=Augustin MA |title=Crystal structure of the human CCA-adding enzyme: insights into template-independent polymerization |journal=J. Mol. Biol. |volume=328 |issue= 5 |pages= 985–94 |year= 2003 |pmid= 12729736 |doi=10.1016/S0022-2836(03)00381-4  |name-list-format=vanc| author2=Reichert AS  | author3=Betat H  | display-authors=3  | last4=Huber  | first4=Robert  | last5=Mörl  | first5=Mario  | last6=Steegborn  | first6=Clemens }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | author=Gerhard DS |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928  |name-list-format=vanc| author2=Wagner L  | author3=Feingold EA  | display-authors=3  | last4=Shenmen  | first4=CM  | last5=Grouse  | first5=LH  | last6=Schuler  | first6=G  | last7=Klein  | first7=SL  | last8=Old  | first8=S  | last9=Rasooly  | first9=R }}
*{{cite journal  | author=Augustin MA, Reichert AS, Betat H, ''et al.'' |title=Crystal structure of the human CCA-adding enzyme: insights into template-independent polymerization. |journal=J. Mol. Biol. |volume=328 |issue= 5 |pages= 985-94 |year= 2003 |pmid= 12729736 |doi=  }}
*{{cite journal  | author=Wiemann S |title=From ORFeome to biology: a functional genomics pipeline |journal=Genome Res. |volume=14 |issue= 10B |pages= 2136–44 |year= 2004 |pmid= 15489336 |doi= 10.1101/gr.2576704 | pmc=528930  |name-list-format=vanc| author2=Arlt D  | author3=Huber W  | display-authors=3  | last4=Wellenreuther  | first4=R  | last5=Schleeger  | first5=S  | last6=Mehrle  | first6=A  | last7=Bechtel  | first7=S  | last8=Sauermann  | first8=M  | last9=Korf  | first9=U }}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | author=Kimura K |title=Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes |journal=Genome Res. |volume=16 |issue= 1 |pages= 55–65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406 | pmc=1356129  |name-list-format=vanc| author2=Wakamatsu A  | author3=Suzuki Y  | display-authors=3  | last4=Ota  | first4=T  | last5=Nishikawa  | first5=T  | last6=Yamashita  | first6=R  | last7=Yamamoto  | first7=J  | last8=Sekine  | first8=M  | last9=Tsuritani  | first9=K }}
*{{cite journal  | author=Wiemann S, Arlt D, Huber W, ''et al.'' |title=From ORFeome to biology: a functional genomics pipeline. |journal=Genome Res. |volume=14 |issue= 10B |pages= 2136-44 |year= 2004 |pmid= 15489336 |doi= 10.1101/gr.2576704 }}
*{{cite journal  | author=Mehrle A |title=The LIFEdb database in 2006 |journal=Nucleic Acids Res. |volume=34 |issue= Database issue |pages= D415–8 |year= 2006 |pmid= 16381901 |doi= 10.1093/nar/gkj139 | pmc=1347501  |name-list-format=vanc| author2=Rosenfelder H  | author3=Schupp I  | display-authors=3  | last4=Del Val  | first4=C  | last5=Arlt  | first5=D  | last6=Hahne  | first6=F  | last7=Bechtel  | first7=S  | last8=Simpson  | first8=J  | last9=Hofmann  | first9=O }}
*{{cite journal  | author=Kimura K, Wakamatsu A, Suzuki Y, ''et al.'' |title=Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. |journal=Genome Res. |volume=16 |issue= 1 |pages= 55-65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406 }}
*{{cite journal  | author=Lizano E |title=A splice variant of the human CCA-adding enzyme with modified activity |journal=J. Mol. Biol. |volume=366 |issue= 4 |pages= 1258–65 |year= 2007 |pmid= 17204286 |doi= 10.1016/j.jmb.2006.12.016 |name-list-format=vanc| author2=Schuster J  | author3=Müller M  | display-authors=3  | last4=Kelso  | first4=J  | last5=Morl  | first5=M }}
*{{cite journal  | author=Mehrle A, Rosenfelder H, Schupp I, ''et al.'' |title=The LIFEdb database in 2006. |journal=Nucleic Acids Res. |volume=34 |issue= Database issue |pages= D415-8 |year= 2006 |pmid= 16381901 |doi= 10.1093/nar/gkj139 }}
*{{cite journal  | author=Lizano E, Schuster J, Müller M, ''et al.'' |title=A splice variant of the human CCA-adding enzyme with modified activity. |journal=J. Mol. Biol. |volume=366 |issue= 4 |pages= 1258-65 |year= 2007 |pmid= 17204286 |doi= 10.1016/j.jmb.2006.12.016 }}
}}
}}
{{refend}}
{{refend}}
{{PDB Gallery|geneid=51095}}
{{Kinases}}
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{{protein-stub}}
{{gene-3-stub}}
{{WikiDoc Sources}}

Latest revision as of 12:18, 15 September 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

tRNA-nucleotidyltransferase 1, is an enzyme that in humans is encoded by the TRNT1 gene.[1][2][3] This enzyme adds the nucleotide sequence CCA to the 3' end of tRNA, using ATP and CTP as substrates. The sequence creates the binding site for an amino acid.[4]


References

  1. ↑ Lai CH, Chou CY, Ch'ang LY, Liu CS, Lin W (Aug 2000). "Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics". Genome Res. 10 (5): 703–13. doi:10.1101/gr.10.5.703. PMC 310876. PMID 10810093.
  2. ↑ Nagaike T, Suzuki T, Tomari Y, Takemoto-Hori C, Negayama F, Watanabe K, Ueda T (Oct 2001). "Identification and characterization of mammalian mitochondrial tRNA nucleotidyltransferases". J Biol Chem. 276 (43): 40041–9. doi:10.1074/jbc.M106202200. PMID 11504732.
  3. ↑ "Entrez Gene: TRNT1 tRNA nucleotidyl transferase, CCA-adding, 1".
  4. ↑ Lizano E, Scheibe M, Rammelt C, Betat H, Mörl M (May 2008). "A comparative analysis of CCA-adding enzymes from human and E. coli: differences in CCA addition and tRNA 3'-end repair". Biochimie. 90 (5): 762–72. doi:10.1016/j.biochi.2007.12.007. PMID 18226598.

Further reading



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