TRO (gene): Difference between revisions

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{{Infobox_gene}}
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'''Trophinin''' is a [[protein]] that in humans is encoded by the ''TRO'' [[gene]].<ref name="pmid9533028">{{cite journal | vauthors = Pack SD, Tanigami A, Ledbetter DH, Sato T, Fukuda MN | title = Assignment of trophoblast/endometrial epithelium cell adhesion molecule trophinin gene TRO to human chromosome bands Xp11.22→p11.21 by in situ hybridization | journal = Cytogenet Cell Genet | volume = 79 | issue = 1–2 | pages = 123–4 |date=Apr 1998 | pmid = 9533028 | pmc =  | doi =10.1159/000134698 }}</ref><ref name="pmid11454705">{{cite journal | vauthors = Chomez P, De Backer O, Bertrand M, De Plaen E, Boon T, Lucas S | title = An overview of the MAGE gene family with the identification of all human members of the family | journal = Cancer Res | volume = 61 | issue = 14 | pages = 5544–51 |date=Jul 2001 | pmid = 11454705 | pmc =  | doi =  }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: TRO trophinin| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7216| accessdate = }}</ref>
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{{GNF_Protein_box
| image =
| image_source = 
| PDB =
| Name = Trophinin
| HGNCid = 12326
| Symbol = TRO
| AltSymbols =; KIAA1114; MAGE-d3; MAGED3
| OMIM = 300132
| ECnumber =
| Homologene = 75113
| MGIid = 1928994
| GeneAtlas_image1 = PBB_GE_TRO_210882_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_TRO_205028_at_tn.png
  | GeneAtlas_image3 = PBB_GE_TRO_211700_s_at_tn.png
  | Function = {{GNF_GO|id=GO:0005515 |text = protein binding}}  
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005737 |text = cytoplasm}} {{GNF_GO|id=GO:0005886 |text = plasma membrane}} {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}}
| Process = {{GNF_GO|id=GO:0007155 |text = cell adhesion}} {{GNF_GO|id=GO:0007156 |text = homophilic cell adhesion}} {{GNF_GO|id=GO:0007566 |text = embryo implantation}} {{GNF_GO|id=GO:0030308 |text = negative regulation of cell growth}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 7216
    | Hs_Ensembl = ENSG00000067445
    | Hs_RefseqProtein = NP_001034794
    | Hs_RefseqmRNA = NM_001039705
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = X
    | Hs_GenLoc_start = 54963969
    | Hs_GenLoc_end = 54974589
    | Hs_Uniprot = Q12816
    | Mm_EntrezGene = 56191
    | Mm_Ensembl = ENSMUSG00000025272
    | Mm_RefseqmRNA = NM_207679
    | Mm_RefseqProtein = NP_997562
    | Mm_GenLoc_db =   
    | Mm_GenLoc_chr = X
    | Mm_GenLoc_start = 145986421
    | Mm_GenLoc_end = 145998299
    | Mm_Uniprot =   
  }}
}}
'''Trophinin''', also known as '''TRO''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: TRO trophinin| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7216| accessdate = }}</ref>


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{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = This gene encodes a membrane protein that mediates apical cell adhesion between trophoblastic cells and luminal epithelial cells of the endometrium and is implicated in the initial attachment during the process of embryo implantation. This gene is related to the MAGED gene family by sequence similarity and chromosome location. Multiple alternatively spliced transcript variants have been found for this gene; however, the full-length nature of some variants has not been defined.<ref name="entrez">{{cite web | title = Entrez Gene: TRO trophinin| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7216| accessdate = }}</ref>
| summary_text = This gene encodes a membrane protein that mediates apical cell adhesion between [[trophoblastic]] cells and [[Lumen (anatomy)|luminal]] [[epithelial]] cells of the [[endometrium]] and is implicated in the initial attachment during the process of [[embryo]] [[Implantation (human embryo)|implantation]]. This gene is related to the MAGED gene family by sequence similarity and chromosome location. Multiple alternatively spliced transcript variants have been found for this gene; however, the full-length nature of some variants has not been defined.<ref name="entrez"/>
}}
}}


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Fukuda MN, Nozawa S |title=Trophinin, tastin, and bystin: a complex mediating unique attachment between trophoblastic and endometrial epithelial cells at their respective apical cell membranes. |journal=Semin. Reprod. Endocrinol. |volume=17 |issue= 3 |pages= 229-34 |year= 2000 |pmid= 10797941 |doi=  }}
*{{cite journal  | vauthors=Fukuda MN, Nozawa S |title=Trophinin, tastin, and bystin: a complex mediating unique attachment between trophoblastic and endometrial epithelial cells at their respective apical cell membranes. |journal=Semin. Reprod. Endocrinol. |volume=17 |issue= 3 |pages= 229–34 |year= 2000 |pmid= 10797941 |doi=10.1055/s-2007-1016230 }}
*{{cite journal | author=Fukuda MN, Sato T, Nakayama J, ''et al.'' |title=Trophinin and tastin, a novel cell adhesion molecule complex with potential involvement in embryo implantation. |journal=Genes Dev. |volume=9 |issue= 10 |pages= 1199-210 |year= 1995 |pmid= 7758945 |doi=  }}
*{{cite journal   |vauthors=Fukuda MN, Sato T, Nakayama J, etal |title=Trophinin and tastin, a novel cell adhesion molecule complex with potential involvement in embryo implantation. |journal=Genes Dev. |volume=9 |issue= 10 |pages= 1199–210 |year= 1995 |pmid= 7758945 |doi=10.1101/gad.9.10.1199 }}
*{{cite journal  | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171-4 |year= 1994 |pmid= 8125298 |doi=  }}
*{{cite journal  | vauthors=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=10.1016/0378-1119(94)90802-8 }}
*{{cite journal  | author=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery. |journal=Genome Res. |volume=6 |issue= 9 |pages= 791-806 |year= 1997 |pmid= 8889548 |doi=  }}
*{{cite journal  | vauthors=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery. |journal=Genome Res. |volume=6 |issue= 9 |pages= 791–806 |year= 1997 |pmid= 8889548 |doi=10.1101/gr.6.9.791 }}
*{{cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, ''et al.'' |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149-56 |year= 1997 |pmid= 9373149 |doi= }}
*{{cite journal   |vauthors=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, etal |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=10.1016/S0378-1119(97)00411-3 }}
*{{cite journal  | author=Pack SD, Tanigami A, Ledbetter DH, ''et al.'' |title=Assignment of trophoblast/endometrial epithelium cell adhesion molecule trophinin gene TRO to human chromosome bands Xp11.22-->p11.21 by in situ hybridization. |journal=Cytogenet. Cell Genet. |volume=79 |issue= 1-2 |pages= 123-4 |year= 1998 |pmid= 9533028 |doi= }}
*{{cite journal   |vauthors=Suzuki N, Zara J, Sato T, etal |title=A cytoplasmic protein, bystin, interacts with trophinin, tastin, and cytokeratin and may be involved in trophinin-mediated cell adhesion between trophoblast and endometrial epithelial cells. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=95 |issue= 9 |pages= 5027–32 |year= 1998 |pmid= 9560222 |doi=10.1073/pnas.95.9.5027  | pmc=20207 }}
*{{cite journal | author=Suzuki N, Zara J, Sato T, ''et al.'' |title=A cytoplasmic protein, bystin, interacts with trophinin, tastin, and cytokeratin and may be involved in trophinin-mediated cell adhesion between trophoblast and endometrial epithelial cells. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=95 |issue= 9 |pages= 5027-32 |year= 1998 |pmid= 9560222 |doi=  }}
*{{cite journal   |vauthors=Suzuki N, Nakayama J, Shih IM, etal |title=Expression of trophinin, tastin, and bystin by trophoblast and endometrial cells in human placenta. |journal=Biol. Reprod. |volume=60 |issue= 3 |pages= 621–7 |year= 1999 |pmid= 10026108 |doi=10.1095/biolreprod60.3.621 }}
*{{cite journal | author=Suzuki N, Nakayama J, Shih IM, ''et al.'' |title=Expression of trophinin, tastin, and bystin by trophoblast and endometrial cells in human placenta. |journal=Biol. Reprod. |volume=60 |issue= 3 |pages= 621-7 |year= 1999 |pmid= 10026108 |doi=  }}
*{{cite journal   |vauthors=Kikuno R, Nagase T, Ishikawa K, etal |title=Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. |journal=DNA Res. |volume=6 |issue= 3 |pages= 197–205 |year= 1999 |pmid= 10470851 |doi=10.1093/dnares/6.3.197 }}
*{{cite journal | author=Kikuno R, Nagase T, Ishikawa K, ''et al.'' |title=Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. |journal=DNA Res. |volume=6 |issue= 3 |pages= 197-205 |year= 1999 |pmid= 10470851 |doi= }}
*{{cite journal  | vauthors=Wang HY, Xing FQ, Chen SL |title=Expression of trophinin in the cycling endometrium and its association with infertility. |journal=Di Yi Jun Yi Da Xue Xue Bao |volume=22 |issue= 6 |pages= 539–41 |year= 2002 |pmid= 12297480 |doi=  }}
*{{cite journal  | author=Chomez P, De Backer O, Bertrand M, ''et al.'' |title=An overview of the MAGE gene family with the identification of all human members of the family. |journal=Cancer Res. |volume=61 |issue= 14 |pages= 5544-51 |year= 2001 |pmid= 11454705 |doi= }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
*{{cite journal  | author=Wang HY, Xing FQ, Chen SL |title=Expression of trophinin in the cycling endometrium and its association with infertility. |journal=Di Yi Jun Yi Da Xue Xue Bao |volume=22 |issue= 6 |pages= 539-41 |year= 2002 |pmid= 12297480 |doi=  }}
*{{cite journal   |vauthors=Imabayashi H, Mori T, Gojo S, etal |title=Redifferentiation of dedifferentiated chondrocytes and chondrogenesis of human bone marrow stromal cells via chondrosphere formation with expression profiling by large-scale cDNA analysis. |journal=Exp. Cell Res. |volume=288 |issue= 1 |pages= 35–50 |year= 2003 |pmid= 12878157 |doi=10.1016/S0014-4827(03)00130-7 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal   |vauthors=Nakayama J, Aoki D, Suga T, etal |title=Implantation-dependent expression of trophinin by maternal fallopian tube epithelia during tubal pregnancies: possible role of human chorionic gonadotrophin on ectopic pregnancy. |journal=Am. J. Pathol. |volume=163 |issue= 6 |pages= 2211–9 |year= 2004 |pmid= 14633596 |doi= 10.1016/S0002-9440(10)63579-1| pmc=1892375 }}
*{{cite journal | author=Imabayashi H, Mori T, Gojo S, ''et al.'' |title=Redifferentiation of dedifferentiated chondrocytes and chondrogenesis of human bone marrow stromal cells via chondrosphere formation with expression profiling by large-scale cDNA analysis. |journal=Exp. Cell Res. |volume=288 |issue= 1 |pages= 35-50 |year= 2003 |pmid= 12878157 |doi=  }}
*{{cite journal   |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal | author=Nakayama J, Aoki D, Suga T, ''et al.'' |title=Implantation-dependent expression of trophinin by maternal fallopian tube epithelia during tubal pregnancies: possible role of human chorionic gonadotrophin on ectopic pregnancy. |journal=Am. J. Pathol. |volume=163 |issue= 6 |pages= 2211-9 |year= 2004 |pmid= 14633596 |doi=  }}
*{{cite journal  | vauthors=Bertrand M, Huijbers I, Chomez P, De Backer O |title=Comparative expression analysis of the MAGED genes during embryogenesis and brain development. |journal=Dev. Dyn. |volume=230 |issue= 2 |pages= 325–34 |year= 2005 |pmid= 15162511 |doi= 10.1002/dvdy.20026 }}
*{{cite journal | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal   |vauthors=Ross MT, Grafham DV, Coffey AJ, etal |title=The DNA sequence of the human X chromosome. |journal=Nature |volume=434 |issue= 7031 |pages= 325–37 |year= 2005 |pmid= 15772651 |doi= 10.1038/nature03440 | pmc=2665286 }}
*{{cite journal  | author=Bertrand M, Huijbers I, Chomez P, De Backer O |title=Comparative expression analysis of the MAGED genes during embryogenesis and brain development. |journal=Dev. Dyn. |volume=230 |issue= 2 |pages= 325-34 |year= 2005 |pmid= 15162511 |doi= 10.1002/dvdy.20026 }}
*{{cite journal   |vauthors=Rual JF, Venkatesan K, Hao T, etal |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
*{{cite journal | author=Ross MT, Grafham DV, Coffey AJ, ''et al.'' |title=The DNA sequence of the human X chromosome. |journal=Nature |volume=434 |issue= 7031 |pages= 325-37 |year= 2005 |pmid= 15772651 |doi= 10.1038/nature03440 }}
*{{cite journal   |vauthors=Aoyama J, Nakayama Y, Sugiyama D, etal |title=Apical cell adhesion molecule, trophinin, localizes to the nuclear envelope. |journal=FEBS Lett. |volume=579 |issue= 28 |pages= 6326–32 |year= 2006 |pmid= 16288751 |doi= 10.1016/j.febslet.2005.10.012 }}
*{{cite journal | author=Rual JF, Venkatesan K, Hao T, ''et al.'' |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173-8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
*{{cite journal | author=Aoyama J, Nakayama Y, Sugiyama D, ''et al.'' |title=Apical cell adhesion molecule, trophinin, localizes to the nuclear envelope. |journal=FEBS Lett. |volume=579 |issue= 28 |pages= 6326-32 |year= 2006 |pmid= 16288751 |doi= 10.1016/j.febslet.2005.10.012 }}
}}
}}
{{refend}}
{{refend}}


{{protein-stub}}
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Latest revision as of 12:19, 15 September 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Trophinin is a protein that in humans is encoded by the TRO gene.[1][2][3]

This gene encodes a membrane protein that mediates apical cell adhesion between trophoblastic cells and luminal epithelial cells of the endometrium and is implicated in the initial attachment during the process of embryo implantation. This gene is related to the MAGED gene family by sequence similarity and chromosome location. Multiple alternatively spliced transcript variants have been found for this gene; however, the full-length nature of some variants has not been defined.[3]

References

  1. ↑ Pack SD, Tanigami A, Ledbetter DH, Sato T, Fukuda MN (Apr 1998). "Assignment of trophoblast/endometrial epithelium cell adhesion molecule trophinin gene TRO to human chromosome bands Xp11.22→p11.21 by in situ hybridization". Cytogenet Cell Genet. 79 (1–2): 123–4. doi:10.1159/000134698. PMID 9533028.
  2. ↑ Chomez P, De Backer O, Bertrand M, De Plaen E, Boon T, Lucas S (Jul 2001). "An overview of the MAGE gene family with the identification of all human members of the family". Cancer Res. 61 (14): 5544–51. PMID 11454705.
  3. ↑ 3.0 3.1 "Entrez Gene: TRO trophinin".

Further reading



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