U2 small nuclear RNA auxiliary factor 1: Difference between revisions

Jump to navigation Jump to search
VisualWikitext
m (Robot: Automated text replacement (-{{reflist}} +{{reflist|2}}, -<references /> +{{reflist|2}}, -{{WikiDoc Cardiology Network Infobox}} +))
 
m (→‎Further reading: task, replaced: J. Cell. Sci. → J. Cell Sci. using AWB)
 
Line 1: Line 1:
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''Splicing factor U2AF 35 kDa subunit''' is a [[protein]] that in humans is encoded by the ''U2AF1'' [[gene]].<ref name="pmid8660980">{{cite journal | vauthors = Lalioti MD, Gos A, Green MR, Rossier C, Morris MA, Antonarakis SE | title = The gene for human U2 snRNP auxiliary factor small 35-kDa subunit (U2AF1) maps to the progressive myoclonus epilepsy (EPM1) critical region on chromosome 21q22.3 | journal = Genomics | volume = 33 | issue = 2 | pages = 298–300 | date = January 1997 | pmid = 8660980 | pmc =  | doi = 10.1006/geno.1996.0196 }}</ref><ref name="pmid7956352">{{cite journal | vauthors = Kalcheva I, Plass C, Sait S, Eddy R, Shows T, Watkins-Chow D, Camper S, Shibata H, Ueda T, Takagi N | title = Comparative mapping of the imprinted U2afbpL gene on mouse chromosome 11 and human chromosome 5 | journal = Cytogenet Cell Genet | volume = 68 | issue = 1–2 | pages = 19–24 | date = Dec 1994 | pmid = 7956352 | pmc = | doi = 10.1159/000133881 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: U2AF1 U2 small nuclear RNA auxiliary factor 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7307| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image = PBB_Protein_U2AF1_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1jmt.
| PDB = {{PDB2|1jmt}}
| Name = U2 small nuclear RNA auxiliary factor 1
| HGNCid = 12453
| Symbol = U2AF1
| AltSymbols =; DKFZp313J1712; FP793; RN; RNU2AF1; U2AF35; U2AFBP
| OMIM = 191317
| ECnumber = 
| Homologene = 14345
| MGIid = 98884
| GeneAtlas_image1 = PBB_GE_U2AF1_202858_at_tn.png
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0003723 |text = RNA binding}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0008270 |text = zinc ion binding}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005681 |text = spliceosome}} {{GNF_GO|id=GO:0015030 |text = Cajal body}}
| Process = {{GNF_GO|id=GO:0000398 |text = nuclear mRNA splicing, via spliceosome}} {{GNF_GO|id=GO:0008380 |text = RNA splicing}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 7307
    | Hs_Ensembl = ENSG00000160201
    | Hs_RefseqProtein = NP_001020374
    | Hs_RefseqmRNA = NM_001025203
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 21
    | Hs_GenLoc_start = 43386136
    | Hs_GenLoc_end = 43400757
    | Hs_Uniprot = Q01081
    | Mm_EntrezGene = 108121
    | Mm_Ensembl = ENSMUSG00000061613
    | Mm_RefseqmRNA = NM_024187
    | Mm_RefseqProtein = NP_077149
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 17
    | Mm_GenLoc_start = 31375793
    | Mm_GenLoc_end = 31387432
    | Mm_Uniprot = Q14C24
  }}
}}
'''U2 small nuclear RNA auxiliary factor 1''', also known as '''U2AF1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: U2AF1 U2 small nuclear RNA auxiliary factor 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7307| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
This gene belongs to the splicing factor [[SR protein|SR]] family of genes. U2 auxiliary factor, comprising a [[U2AF2|large]] and a small subunit, is a non-snRNP protein required for the binding of U2 snRNP to the pre-mRNA branch site. This gene encodes the small subunit which plays a critical role in both constitutive and [[exonic splicing enhancer|enhancer]]-dependent RNA splicing by directly mediating interactions between the large subunit and proteins bound to the enhancers. [[alternative splicing|Alternatively spliced]] transcript variants encoding different [[protein isoforms|isoforms]] have been identified.<ref name="entrez" />
{{PBB_Summary
| section_title =
| summary_text = This gene belongs to the splicing factor SR family of genes. U2 auxiliary factor, comprising a large and a small subunit, is a non-snRNP protein required for the binding of U2 snRNP to the pre-mRNA branch site. This gene encodes the small subunit which plays a critical role in both constitutive and enhancer-dependent RNA splicing by directly mediating interactions between the large subunit and proteins bound to the enhancers. Alternatively spliced transcript variants encoding different isoforms have been identified.<ref name="entrez">{{cite web | title = Entrez Gene: U2AF1 U2 small nuclear RNA auxiliary factor 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7307| accessdate = }}</ref>
}}


==References==
== Interactions ==
{{reflist|2}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal  | author=Zhang M, Zamore PD, Carmo-Fonseca M, ''et al.'' |title=Cloning and intracellular localization of the U2 small nuclear ribonucleoprotein auxiliary factor small subunit. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=89 |issue= 18 |pages= 8769-73 |year= 1992 |pmid= 1388271 |doi=  }}
*{{cite journal  | author=Zamore PD, Green MR |title=Biochemical characterization of U2 snRNP auxiliary factor: an essential pre-mRNA splicing factor with a novel intranuclear distribution. |journal=EMBO J. |volume=10 |issue= 1 |pages= 207-14 |year= 1991 |pmid= 1824937 |doi=  }}
*{{cite journal  | author=Kalcheva I, Plass C, Sait S, ''et al.'' |title=Comparative mapping of the imprinted U2afbpL gene on mouse chromosome 11 and human chromosome 5. |journal=Cytogenet. Cell Genet. |volume=68 |issue= 1-2 |pages= 19-24 |year= 1994 |pmid= 7956352 |doi=  }}
*{{cite journal  | author=Wu JY, Maniatis T |title=Specific interactions between proteins implicated in splice site selection and regulated alternative splicing. |journal=Cell |volume=75 |issue= 6 |pages= 1061-70 |year= 1994 |pmid= 8261509 |doi=  }}
*{{cite journal  | author=Zuo P, Maniatis T |title=The splicing factor U2AF35 mediates critical protein-protein interactions in constitutive and enhancer-dependent splicing. |journal=Genes Dev. |volume=10 |issue= 11 |pages= 1356-68 |year= 1996 |pmid= 8647433 |doi=  }}
*{{cite journal  | author=Lalioti MD, Gos A, Green MR, ''et al.'' |title=The gene for human U2 snRNP auxiliary factor small 35-kDa subunit (U2AF1) maps to the progressive myoclonus epilepsy (EPM1) critical region on chromosome 21q22.3. |journal=Genomics |volume=33 |issue= 2 |pages= 298-300 |year= 1997 |pmid= 8660980 |doi= 10.1006/geno.1996.0196 }}
*{{cite journal  | author=Hong W, Bennett M, Xiao Y, ''et al.'' |title=Association of U2 snRNP with the spliceosomal complex E. |journal=Nucleic Acids Res. |volume=25 |issue= 2 |pages= 354-61 |year= 1997 |pmid= 9016565 |doi=  }}
*{{cite journal  | author=Tronchère H, Wang J, Fu XD |title=A protein related to splicing factor U2AF35 that interacts with U2AF65 and SR proteins in splicing of pre-mRNA. |journal=Nature |volume=388 |issue= 6640 |pages= 397-400 |year= 1997 |pmid= 9237760 |doi= 10.1038/41137 }}
*{{cite journal  | author=Wang HY, Lin W, Dyck JA, ''et al.'' |title=SRPK2: a differentially expressed SR protein-specific kinase involved in mediating the interaction and localization of pre-mRNA splicing factors in mammalian cells. |journal=J. Cell Biol. |volume=140 |issue= 4 |pages= 737-50 |year= 1998 |pmid= 9472028 |doi=  }}
*{{cite journal  | author=Rudner DZ, Kanaar R, Breger KS, Rio DC |title=Interaction between subunits of heterodimeric splicing factor U2AF is essential in vivo. |journal=Mol. Cell. Biol. |volume=18 |issue= 4 |pages= 1765-73 |year= 1998 |pmid= 9528748 |doi=  }}
*{{cite journal  | author=Lallena MJ, Martínez C, Valcárcel J, Correas I |title=Functional association of nuclear protein 4.1 with pre-mRNA splicing factors. |journal=J. Cell. Sci. |volume=111 ( Pt 14) |issue=  |pages= 1963-71 |year= 1998 |pmid= 9645944 |doi=  }}
*{{cite journal  | author=Gozani O, Potashkin J, Reed R |title=A potential role for U2AF-SAP 155 interactions in recruiting U2 snRNP to the branch site. |journal=Mol. Cell. Biol. |volume=18 |issue= 8 |pages= 4752-60 |year= 1998 |pmid= 9671485 |doi=  }}
*{{cite journal  | author=Neubauer G, King A, Rappsilber J, ''et al.'' |title=Mass spectrometry and EST-database searching allows characterization of the multi-protein spliceosome complex. |journal=Nat. Genet. |volume=20 |issue= 1 |pages= 46-50 |year= 1998 |pmid= 9731529 |doi= 10.1038/1700 }}
*{{cite journal  | author=Xiao SH, Manley JL |title=Phosphorylation-dephosphorylation differentially affects activities of splicing factor ASF/SF2. |journal=EMBO J. |volume=17 |issue= 21 |pages= 6359-67 |year= 1999 |pmid= 9799243 |doi= 10.1093/emboj/17.21.6359 }}
*{{cite journal  | author=Hattori M, Fujiyama A, Taylor TD, ''et al.'' |title=The DNA sequence of human chromosome 21. |journal=Nature |volume=405 |issue= 6784 |pages= 311-9 |year= 2000 |pmid= 10830953 |doi= 10.1038/35012518 }}
*{{cite journal  | author=de Vries H, Rüegsegger U, Hübner W, ''et al.'' |title=Human pre-mRNA cleavage factor II(m) contains homologs of yeast proteins and bridges two other cleavage factors. |journal=EMBO J. |volume=19 |issue= 21 |pages= 5895-904 |year= 2000 |pmid= 11060040 |doi= 10.1093/emboj/19.21.5895 }}
*{{cite journal  | author=Gama-Carvalho M, Carvalho MP, Kehlenbach A, ''et al.'' |title=Nucleocytoplasmic shuttling of heterodimeric splicing factor U2AF. |journal=J. Biol. Chem. |volume=276 |issue= 16 |pages= 13104-12 |year= 2001 |pmid= 11118443 |doi= 10.1074/jbc.M008759200 }}
*{{cite journal  | author=Adams DJ, van der Weyden L, Mayeda A, ''et al.'' |title=ZNF265--a novel spliceosomal protein able to induce alternative splicing. |journal=J. Cell Biol. |volume=154 |issue= 1 |pages= 25-32 |year= 2001 |pmid= 11448987 |doi=  }}
*{{cite journal  | author=Will CL, Schneider C, MacMillan AM, ''et al.'' |title=A novel U2 and U11/U12 snRNP protein that associates with the pre-mRNA branch site. |journal=EMBO J. |volume=20 |issue= 16 |pages= 4536-46 |year= 2001 |pmid= 11500380 |doi= 10.1093/emboj/20.16.4536 }}
*{{cite journal  | author=Nesic D, Krämer A |title=Domains in human splicing factors SF3a60 and SF3a66 required for binding to SF3a120, assembly of the 17S U2 snRNP, and prespliceosome formation. |journal=Mol. Cell. Biol. |volume=21 |issue= 19 |pages= 6406-17 |year= 2001 |pmid= 11533230 |doi=  }}
}}
{{refend}}


{{gene-21-stub}}
U2 small nuclear RNA auxiliary factor 1 has been shown to [[Protein-protein interaction|interact]] with:
{{WikiDoc Sources}}
* [[ASF/SF2]],<ref name = pmid9799243>{{cite journal | vauthors = Xiao SH, Manley JL | title = Phosphorylation-dephosphorylation differentially affects activities of splicing factor ASF/SF2 | journal = EMBO J. | volume = 17 | issue = 21 | pages = 6359–67 | date = November 1998 | pmid = 9799243 | pmc = 1170960 | doi = 10.1093/emboj/17.21.6359 }}</ref><ref name = pmid8816452>{{cite journal | vauthors = Zhang WJ, Wu JY | title = Functional properties of p54, a novel SR protein active in constitutive and alternative splicing | journal = Mol. Cell. Biol. | volume = 16 | issue = 10 | pages = 5400–8 | date = October 1996 | pmid = 8816452 | pmc = 231539 | doi =  }}</ref>
* [[NXF1]],<ref name = pmid11724776>{{cite journal | vauthors = Zolotukhin AS, Tan W, Bear J, Smulevitch S, Felber BK | title = U2AF participates in the binding of TAP (NXF1) to mRNA | journal = J. Biol. Chem. | volume = 277 | issue = 6 | pages = 3935–42 | date = February 2002 | pmid = 11724776 | doi = 10.1074/jbc.M107598200 }}</ref>
* [[RP9]],<ref name = pmid15474994>{{cite journal | vauthors = Maita H, Kitaura H, Keen TJ, Inglehearn CF, Ariga H, Iguchi-Ariga SM | title = PAP-1, the mutated gene underlying the RP9 form of dominant retinitis pigmentosa, is a splicing factor | journal = Exp. Cell Res. | volume = 300 | issue = 2 | pages = 283–96 | date = November 2004 | pmid = 15474994 | doi = 10.1016/j.yexcr.2004.07.029 }}</ref>
* [[SMNDC1]],<ref name = pmid18211889>{{cite journal | vauthors = Little JT, Jurica MS | title = Splicing factor SPF30 bridges an interaction between the prespliceosome protein U2AF35 and tri-small nuclear ribonucleoprotein protein hPrp3 | journal = J. Biol. Chem. | volume = 283 | issue = 13 | pages = 8145–52 | date = March 2008 | pmid = 18211889 | doi = 10.1074/jbc.M707984200 }}</ref>
* [[U2AF2]],<ref name = pmid16189514>{{cite journal | vauthors = Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M | title = Towards a proteome-scale map of the human protein-protein interaction network | journal = Nature | volume = 437 | issue = 7062 | pages = 1173–8 | date = October 2005 | pmid = 16189514 | doi = 10.1038/nature04209 }}</ref><ref name = pmid1388271>{{cite journal | vauthors = Zhang M, Zamore PD, Carmo-Fonseca M, Lamond AI, Green MR | title = Cloning and intracellular localization of the U2 small nuclear ribonucleoprotein auxiliary factor small subunit | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 89 | issue = 18 | pages = 8769–73 | date = September 1992 | pmid = 1388271 | pmc = 50002 | doi =  10.1073/pnas.89.18.8769}}</ref>  and
* [[ZRANB2]].<ref name = pmid11448987>{{cite journal | vauthors = Adams DJ, van der Weyden L, Mayeda A, Stamm S, Morris BJ, Rasko JE | title = ZNF265--a novel spliceosomal protein able to induce alternative splicing | journal = J. Cell Biol. | volume = 154 | issue = 1 | pages = 25–32 | date = July 2001 | pmid = 11448987 | pmc = 2196870 | doi =  10.1083/jcb.200010059}}</ref>
 
== References ==
{{Reflist}}
 
== Further reading ==
{{Refbegin | 2}}
* {{cite journal | vauthors = Zhang M, Zamore PD, Carmo-Fonseca M, Lamond AI, Green MR | title = Cloning and intracellular localization of the U2 small nuclear ribonucleoprotein auxiliary factor small subunit | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 89 | issue = 18 | pages = 8769–8773 | year = 1992 | pmid = 1388271 | pmc = 50002 | doi = 10.1073/pnas.89.18.8769 }}
* {{cite journal | vauthors = Zamore PD, Green MR | title = Biochemical characterization of U2 snRNP auxiliary factor: an essential pre-mRNA splicing factor with a novel intranuclear distribution | journal = EMBO J. | volume = 10 | issue = 1 | pages = 207–14 | year = 1991 | pmid = 1824937 | pmc = 452631 | doi =  }}
* {{cite journal | vauthors = Wu JY, Maniatis T | title = Specific interactions between proteins implicated in splice site selection and regulated alternative splicing | journal = Cell | volume = 75 | issue = 6 | pages = 1061–1070 | year = 1994 | pmid = 8261509 | doi = 10.1016/0092-8674(93)90316-I }}
* {{cite journal | vauthors = Zuo P, Maniatis T | title = The splicing factor U2AF35 mediates critical protein-protein interactions in constitutive and enhancer-dependent splicing | journal = Genes Dev. | volume = 10 | issue = 11 | pages = 1356–1368 | year = 1996 | pmid = 8647433 | doi = 10.1101/gad.10.11.1356 }}
* {{cite journal | vauthors = Hong W, Bennett M, Xiao Y, Feld Kramer R, Wang C, Reed R | title = Association of U2 snRNP with the spliceosomal complex E | journal = Nucleic Acids Res. | volume = 25 | issue = 2 | pages = 354–361 | year = 1997 | pmid = 9016565 | pmc = 146436 | doi = 10.1093/nar/25.2.354 }}
* {{cite journal | vauthors = Tronchère H, Wang J, Fu XD | title = A protein related to splicing factor U2AF35 that interacts with U2AF65 and SR proteins in splicing of pre-mRNA | journal = Nature | volume = 388 | issue = 6640 | pages = 397–400 | year = 1997 | pmid = 9237760 | doi = 10.1038/41137 }}
* {{cite journal | vauthors = Wang HY, Lin W, Dyck JA, Yeakley JM, Songyang Z, Cantley LC, Fu XD | title = SRPK2: a differentially expressed SR protein-specific kinase involved in mediating the interaction and localization of pre-mRNA splicing factors in mammalian cells | journal = J. Cell Biol. | volume = 140 | issue = 4 | pages = 737–750 | year = 1998 | pmid = 9472028 | pmc = 2141757 | doi = 10.1083/jcb.140.4.737 }}
* {{cite journal | vauthors = Rudner DZ, Kanaar R, Breger KS, Rio DC | title = Interaction between subunits of heterodimeric splicing factor U2AF is essential in vivo | journal = Mol. Cell. Biol. | volume = 18 | issue = 4 | pages = 1765–73 | year = 1998 | pmid = 9528748 | pmc = 121406 | doi =  }}
* {{cite journal | vauthors = Lallena MJ, Martínez C, Valcárcel J, Correas I | title = Functional association of nuclear protein 4.1 with pre-mRNA splicing factors | journal = J. Cell Sci. | volume = 111 | issue = 14 | pages = 1963–71 | year = 1998 | pmid = 9645944 | doi =  }}
* {{cite journal | vauthors = Gozani O, Potashkin J, Reed R | title = A potential role for U2AF-SAP 155 interactions in recruiting U2 snRNP to the branch site | journal = Mol. Cell. Biol. | volume = 18 | issue = 8 | pages = 4752–60 | year = 1998 | pmid = 9671485 | pmc = 109061 | doi =  10.1128/mcb.18.8.4752}}
* {{cite journal | vauthors = Neubauer G, King A, Rappsilber J, Calvio C, Watson M, Ajuh P, Sleeman J, Lamond A, Mann M | title = Mass spectrometry and EST-database searching allows characterization of the multi-protein spliceosome complex | journal = Nat. Genet. | volume = 20 | issue = 1 | pages = 46–50 | year = 1998 | pmid = 9731529 | doi = 10.1038/1700 }}
* {{cite journal | vauthors = Xiao SH, Manley JL | title = Phosphorylation-dephosphorylation differentially affects activities of splicing factor ASF/SF2 | journal = EMBO J. | volume = 17 | issue = 21 | pages = 6359–6367 | year = 1999 | pmid = 9799243 | pmc = 1170960 | doi = 10.1093/emboj/17.21.6359 }}
* {{cite journal | vauthors = de Vries H, Rüegsegger U, Hübner W, Friedlein A, Langen H, Keller W | title = Human pre-mRNA cleavage factor II(m) contains homologs of yeast proteins and bridges two other cleavage factors | journal = EMBO J. | volume = 19 | issue = 21 | pages = 5895–5904 | year = 2000 | pmid = 11060040 | pmc = 305781 | doi = 10.1093/emboj/19.21.5895 }}
* {{cite journal | vauthors = Gama-Carvalho M, Carvalho MP, Kehlenbach A, Valcarcel J, Carmo-Fonseca M | title = Nucleocytoplasmic shuttling of heterodimeric splicing factor U2AF | journal = J. Biol. Chem. | volume = 276 | issue = 16 | pages = 13104–13112 | year = 2001 | pmid = 11118443 | doi = 10.1074/jbc.M008759200 }}
* {{cite journal | vauthors = Adams DJ, van der Weyden L, Mayeda A, Stamm S, Morris BJ, Rasko JE | title = ZNF265--a novel spliceosomal protein able to induce alternative splicing | journal = J. Cell Biol. | volume = 154 | issue = 1 | pages = 25–32 | year = 2001 | pmid = 11448987 | pmc = 2196870 | doi = 10.1083/jcb.200010059 }}
* {{cite journal | vauthors = Will CL, Schneider C, MacMillan AM, Katopodis NF, Neubauer G, Wilm M, Lührmann R, Query CC | title = A novel U2 and U11/U12 snRNP protein that associates with the pre-mRNA branch site | journal = EMBO J. | volume = 20 | issue = 16 | pages = 4536–4546 | year = 2001 | pmid = 11500380 | pmc = 125580 | doi = 10.1093/emboj/20.16.4536 }}
* {{cite journal | vauthors = Nesic D, Krämer A | title = Domains in human splicing factors SF3a60 and SF3a66 required for binding to SF3a120, assembly of the 17S U2 snRNP, and prespliceosome formation | journal = Mol. Cell. Biol. | volume = 21 | issue = 19 | pages = 6406–6417 | year = 2001 | pmid = 11533230 | pmc = 99788 | doi = 10.1128/MCB.21.19.6406-6417.2001 }}
{{Refend}}
 
{{PDB Gallery|geneid=7307}}

Latest revision as of 22:33, 8 November 2017

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

n/a

n/a

Ensembl

n/a

n/a

UniProt

n/a

n/a

RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

n/a

Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Splicing factor U2AF 35 kDa subunit is a protein that in humans is encoded by the U2AF1 gene.[1][2][3]

Function

This gene belongs to the splicing factor SR family of genes. U2 auxiliary factor, comprising a large and a small subunit, is a non-snRNP protein required for the binding of U2 snRNP to the pre-mRNA branch site. This gene encodes the small subunit which plays a critical role in both constitutive and enhancer-dependent RNA splicing by directly mediating interactions between the large subunit and proteins bound to the enhancers. Alternatively spliced transcript variants encoding different isoforms have been identified.[3]

Interactions

U2 small nuclear RNA auxiliary factor 1 has been shown to interact with:

References

  1. ↑ Lalioti MD, Gos A, Green MR, Rossier C, Morris MA, Antonarakis SE (January 1997). "The gene for human U2 snRNP auxiliary factor small 35-kDa subunit (U2AF1) maps to the progressive myoclonus epilepsy (EPM1) critical region on chromosome 21q22.3". Genomics. 33 (2): 298–300. doi:10.1006/geno.1996.0196. PMID 8660980.
  2. ↑ Kalcheva I, Plass C, Sait S, Eddy R, Shows T, Watkins-Chow D, Camper S, Shibata H, Ueda T, Takagi N (Dec 1994). "Comparative mapping of the imprinted U2afbpL gene on mouse chromosome 11 and human chromosome 5". Cytogenet Cell Genet. 68 (1–2): 19–24. doi:10.1159/000133881. PMID 7956352.
  3. ↑ 3.0 3.1 "Entrez Gene: U2AF1 U2 small nuclear RNA auxiliary factor 1".
  4. ↑ Xiao SH, Manley JL (November 1998). "Phosphorylation-dephosphorylation differentially affects activities of splicing factor ASF/SF2". EMBO J. 17 (21): 6359–67. doi:10.1093/emboj/17.21.6359. PMC 1170960. PMID 9799243.
  5. ↑ Zhang WJ, Wu JY (October 1996). "Functional properties of p54, a novel SR protein active in constitutive and alternative splicing". Mol. Cell. Biol. 16 (10): 5400–8. PMC 231539. PMID 8816452.
  6. ↑ Zolotukhin AS, Tan W, Bear J, Smulevitch S, Felber BK (February 2002). "U2AF participates in the binding of TAP (NXF1) to mRNA". J. Biol. Chem. 277 (6): 3935–42. doi:10.1074/jbc.M107598200. PMID 11724776.
  7. ↑ Maita H, Kitaura H, Keen TJ, Inglehearn CF, Ariga H, Iguchi-Ariga SM (November 2004). "PAP-1, the mutated gene underlying the RP9 form of dominant retinitis pigmentosa, is a splicing factor". Exp. Cell Res. 300 (2): 283–96. doi:10.1016/j.yexcr.2004.07.029. PMID 15474994.
  8. ↑ Little JT, Jurica MS (March 2008). "Splicing factor SPF30 bridges an interaction between the prespliceosome protein U2AF35 and tri-small nuclear ribonucleoprotein protein hPrp3". J. Biol. Chem. 283 (13): 8145–52. doi:10.1074/jbc.M707984200. PMID 18211889.
  9. ↑ Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
  10. ↑ Zhang M, Zamore PD, Carmo-Fonseca M, Lamond AI, Green MR (September 1992). "Cloning and intracellular localization of the U2 small nuclear ribonucleoprotein auxiliary factor small subunit". Proc. Natl. Acad. Sci. U.S.A. 89 (18): 8769–73. doi:10.1073/pnas.89.18.8769. PMC 50002. PMID 1388271.
  11. ↑ Adams DJ, van der Weyden L, Mayeda A, Stamm S, Morris BJ, Rasko JE (July 2001). "ZNF265--a novel spliceosomal protein able to induce alternative splicing". J. Cell Biol. 154 (1): 25–32. doi:10.1083/jcb.200010059. PMC 2196870. PMID 11448987.

Further reading

Retrieved from "https://www.wikidoc.org/index.php?title=U2_small_nuclear_RNA_auxiliary_factor_1&oldid=1419917"