UPK1A: Difference between revisions

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{{Infobox_gene}}
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'''Uroplakin-1a''' is a [[protein]] that in humans is encoded by the ''UPK1A'' [[gene]].<ref name="pmid9846985">{{cite journal | vauthors = Lobban ED, Smith BA, Hall GD, Harnden P, Roberts P, Selby PJ, Trejdosiewicz LK, Southgate J | title = Uroplakin gene expression by normal and neoplastic human urothelium | journal = Am J Pathol | volume = 153 | issue = 6 | pages = 1957–67 |date=Dec 1998 | pmid = 9846985 | pmc = 1866332 | doi =10.1016/S0002-9440(10)65709-4 }}</ref><ref name="pmid10404304">{{cite journal | vauthors = Yuasa T, Yoshiki T, Isono T, Tanaka T, Hayashida H, Okada Y | title = Expression of transitional cell-specific genes, uroplakin Ia and II, in bladder cancer: detection of circulating cancer cells in the peripheral blood of metastatic patients | journal = Int J Urol | volume = 6 | issue = 6 | pages = 286–92 |date=Sep 1999 | pmid = 10404304 | pmc =  | doi =10.1046/j.1442-2042.1999.00064.x }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: UPK1A uroplakin 1A| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=11045| accessdate = }}</ref>
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{{GNF_Protein_box
| image =
| image_source = 
| PDB =
| Name = Uroplakin 1A
| HGNCid = 12577
| Symbol = UPK1A
| AltSymbols =; MGC129751; MGC129752; MGC14388; TSPAN21; UP1A; UPIA; UPKA
| OMIM =
| ECnumber =
| Homologene = 21383
| MGIid = 98911
| GeneAtlas_image1 = PBB_GE_UPK1A_214624_at_tn.png
  | Function = {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0042803 |text = protein homodimerization activity}} {{GNF_GO|id=GO:0048029 |text = monosaccharide binding}}
| Component = {{GNF_GO|id=GO:0005783 |text = endoplasmic reticulum}} {{GNF_GO|id=GO:0005886 |text = plasma membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0006897 |text = endocytosis}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0030855 |text = epithelial cell differentiation}} {{GNF_GO|id=GO:0051259 |text = protein oligomerization}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 11045
    | Hs_Ensembl = ENSG00000105668
    | Hs_RefseqProtein = NP_008931
    | Hs_RefseqmRNA = NM_007000
    | Hs_GenLoc_db =   
    | Hs_GenLoc_chr = 19
    | Hs_GenLoc_start = 40849555
    | Hs_GenLoc_end = 40861207
    | Hs_Uniprot = O00322
    | Mm_EntrezGene = 109637
    | Mm_Ensembl = ENSMUSG00000006313
    | Mm_RefseqmRNA = NM_026815
    | Mm_RefseqProtein = NP_081091
    | Mm_GenLoc_db =   
    | Mm_GenLoc_chr = 7
    | Mm_GenLoc_start = 30311852
    | Mm_GenLoc_end = 30321494
    | Mm_Uniprot = Q9D132
  }}
}}
'''Uroplakin 1A''', also known as '''UPK1A''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: UPK1A uroplakin 1A| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=11045| accessdate = }}</ref>


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{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is found in the asymmetrical unit membrane (AUM) where it can complex with other transmembrane 4 superfamily proteins. It may play a role in normal bladder epithelial physiology, possibly in regulating membrane permeability of superficial umbrella cells or in stabilizing the apical membrane through AUM/cytoskeletal interactions.<ref name="entrez">{{cite web | title = Entrez Gene: UPK1A uroplakin 1A| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=11045| accessdate = }}</ref>
| summary_text = The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is found in the asymmetrical unit membrane (AUM) where it can complex with other transmembrane 4 superfamily proteins. It may play a role in normal bladder epithelial physiology, possibly in regulating membrane permeability of superficial umbrella cells or in stabilizing the apical membrane through AUM/cytoskeletal interactions.<ref name="entrez"/>
}}
}}


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Berditchevski F |title=Complexes of tetraspanins with integrins: more than meets the eye. |journal=J. Cell. Sci. |volume=114 |issue= Pt 23 |pages= 4143-51 |year= 2002 |pmid= 11739647 |doi=  }}
*{{cite journal  | author=Berditchevski F |title=Complexes of tetraspanins with integrins: more than meets the eye |journal=J. Cell Sci. |volume=114 |issue= Pt 23 |pages= 4143–51 |year= 2002 |pmid= 11739647 |doi=  }}
*{{cite journal  | author=Yu J, Lin JH, Wu XR, Sun TT |title=Uroplakins Ia and Ib, two major differentiation products of bladder epithelium, belong to a family of four transmembrane domain (4TM) proteins. |journal=J. Cell Biol. |volume=125 |issue= 1 |pages= 171-82 |year= 1994 |pmid= 8138569 |doi=  }}
*{{cite journal  | vauthors=Yu J, Lin JH, Wu XR, Sun TT |title=Uroplakins Ia and Ib, two major differentiation products of bladder epithelium, belong to a family of four transmembrane domain (4TM) proteins |journal=J. Cell Biol. |volume=125 |issue= 1 |pages= 171–82 |year= 1994 |pmid= 8138569 |doi=10.1083/jcb.125.1.171  | pmc=2120008 }}
*{{cite journal  | author=Wu XR, Medina JJ, Sun TT |title=Selective interactions of UPIa and UPIb, two members of the transmembrane 4 superfamily, with distinct single transmembrane-domained proteins in differentiated urothelial cells. |journal=J. Biol. Chem. |volume=270 |issue= 50 |pages= 29752-9 |year= 1996 |pmid= 8530366 |doi= }}
*{{cite journal  | vauthors=Wu XR, Medina JJ, Sun TT |title=Selective interactions of UPIa and UPIb, two members of the transmembrane 4 superfamily, with distinct single transmembrane-domained proteins in differentiated urothelial cells |journal=J. Biol. Chem. |volume=270 |issue= 50 |pages= 29752–9 |year= 1996 |pmid= 8530366 |doi=10.1074/jbc.270.50.29752 }}
*{{cite journal  | author=Lobban ED, Smith BA, Hall GD, ''et al.'' |title=Uroplakin gene expression by normal and neoplastic human urothelium. |journal=Am. J. Pathol. |volume=153 |issue= 6 |pages= 1957-67 |year= 1998 |pmid= 9846985 |doi= }}
*{{cite journal  | vauthors=Ogawa K, Johansson SL, Cohen SM |title=Immunohistochemical analysis of uroplakins, urothelial specific proteins, in ovarian Brenner tumors, normal tissues, and benign and neoplastic lesions of the female genital tract |journal=Am. J. Pathol. |volume=155 |issue= 4 |pages= 1047–50 |year= 1999 |pmid= 10514386 |doi= 10.1016/S0002-9440(10)65206-6| pmc=1867018 }}
*{{cite journal  | author=Yuasa T, Yoshiki T, Isono T, ''et al.'' |title=Expression of transitional cell-specific genes, uroplakin Ia and II, in bladder cancer: detection of circulating cancer cells in the peripheral blood of metastatic patients. |journal=Int. J. Urol. |volume=6 |issue= 6 |pages= 286-92 |year= 1999 |pmid= 10404304 |doi=  }}
*{{cite journal   |vauthors=Kageyama S, Yoshiki T, Isono T, etal |title=High expression of human uroplakin Ia in urinary bladder transitional cell carcinoma |journal=Jpn. J. Cancer Res. |volume=93 |issue= 5 |pages= 523–31 |year= 2003 |pmid= 12036448 |doi=  10.1111/j.1349-7006.2002.tb01287.x}}
*{{cite journal  | author=Ogawa K, Johansson SL, Cohen SM |title=Immunohistochemical analysis of uroplakins, urothelial specific proteins, in ovarian Brenner tumors, normal tissues, and benign and neoplastic lesions of the female genital tract. |journal=Am. J. Pathol. |volume=155 |issue= 4 |pages= 1047-50 |year= 1999 |pmid= 10514386 |doi=  }}
*{{cite journal  | vauthors=Tu L, Sun TT, Kreibich G |title=Specific heterodimer formation is a prerequisite for uroplakins to exit from the endoplasmic reticulum |journal=Mol. Biol. Cell |volume=13 |issue= 12 |pages= 4221–30 |year= 2003 |pmid= 12475947 |doi= 10.1091/mbc.E02-04-0211 | pmc=138628 }}
*{{cite journal | author=Kageyama S, Yoshiki T, Isono T, ''et al.'' |title=High expression of human uroplakin Ia in urinary bladder transitional cell carcinoma. |journal=Jpn. J. Cancer Res. |volume=93 |issue= 5 |pages= 523-31 |year= 2003 |pmid= 12036448 |doi=  }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
*{{cite journal  | author=Tu L, Sun TT, Kreibich G |title=Specific heterodimer formation is a prerequisite for uroplakins to exit from the endoplasmic reticulum. |journal=Mol. Biol. Cell |volume=13 |issue= 12 |pages= 4221-30 |year= 2003 |pmid= 12475947 |doi= 10.1091/mbc.E02-04-0211 }}
*{{cite journal   |vauthors=Grimwood J, Gordon LA, Olsen A, etal |title=The DNA sequence and biology of human chromosome 19 |journal=Nature |volume=428 |issue= 6982 |pages= 529–35 |year= 2004 |pmid= 15057824 |doi= 10.1038/nature02399 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal   |vauthors=Yuasa T, Yoshiki T, Isono T, etal |title=Molecular cloning and expression of uroplakins in transitional cell carcinoma |journal=Adv. Exp. Med. Biol. |volume=539 |issue= Pt A |pages= 33–46 |year= 2004 |pmid= 15088894 |doi=  10.1007/978-1-4419-8889-8_3}}
*{{cite journal | author=Grimwood J, Gordon LA, Olsen A, ''et al.'' |title=The DNA sequence and biology of human chromosome 19. |journal=Nature |volume=428 |issue= 6982 |pages= 529-35 |year= 2004 |pmid= 15057824 |doi= 10.1038/nature02399 }}
*{{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
*{{cite journal | author=Yuasa T, Yoshiki T, Isono T, ''et al.'' |title=Molecular cloning and expression of uroplakins in transitional cell carcinoma. |journal=Adv. Exp. Med. Biol. |volume=539 |issue= Pt A |pages= 33-46 |year= 2004 |pmid= 15088894 |doi=  }}
*{{cite journal   |vauthors=Hall GD, Weeks RJ, Olsburgh J, etal |title=Transcriptional control of the human urothelial-specific gene, uroplakin Ia |journal=Biochim. Biophys. Acta |volume=1729 |issue= 2 |pages= 126–34 |year= 2005 |pmid= 15913809 |doi= 10.1016/j.bbaexp.2005.04.004 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal | author=Hall GD, Weeks RJ, Olsburgh J, ''et al.'' |title=Transcriptional control of the human urothelial-specific gene, uroplakin Ia. |journal=Biochim. Biophys. Acta |volume=1729 |issue= 2 |pages= 126-34 |year= 2005 |pmid= 15913809 |doi= 10.1016/j.bbaexp.2005.04.004 }}
}}
}}
{{refend}}
{{refend}}


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[[Category:Uroplakins]]
 
 
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Revision as of 22:34, 8 November 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Uroplakin-1a is a protein that in humans is encoded by the UPK1A gene.[1][2][3]

The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is found in the asymmetrical unit membrane (AUM) where it can complex with other transmembrane 4 superfamily proteins. It may play a role in normal bladder epithelial physiology, possibly in regulating membrane permeability of superficial umbrella cells or in stabilizing the apical membrane through AUM/cytoskeletal interactions.[3]

References

  1. ↑ Lobban ED, Smith BA, Hall GD, Harnden P, Roberts P, Selby PJ, Trejdosiewicz LK, Southgate J (Dec 1998). "Uroplakin gene expression by normal and neoplastic human urothelium". Am J Pathol. 153 (6): 1957–67. doi:10.1016/S0002-9440(10)65709-4. PMC 1866332. PMID 9846985.
  2. ↑ Yuasa T, Yoshiki T, Isono T, Tanaka T, Hayashida H, Okada Y (Sep 1999). "Expression of transitional cell-specific genes, uroplakin Ia and II, in bladder cancer: detection of circulating cancer cells in the peripheral blood of metastatic patients". Int J Urol. 6 (6): 286–92. doi:10.1046/j.1442-2042.1999.00064.x. PMID 10404304.
  3. ↑ 3.0 3.1 "Entrez Gene: UPK1A uroplakin 1A".

Further reading


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