UPK2: Difference between revisions

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Latest revision as of 09:51, 17 September 2017

Uroplakin-2 is a protein that in humans is encoded by the UPK2 gene.^[1]^[2]^[3]

References

↑ Wu RL, Osman I, Wu XR, Lu ML, Zhang ZF, Liang FX, Hamza R, Scher H, Cordon-Cardo C, Sun TT (Apr 1998). "Uroplakin II gene is expressed in transitional cell carcinoma but not in bilharzial bladder squamous cell carcinoma: alternative pathways of bladder epithelial differentiation and tumor formation". Cancer Res. 58 (6): 1291–7. doi:10.1097/00005392-199811000-00097. PMID 9515818.
↑ Lobban ED, Smith BA, Hall GD, Harnden P, Roberts P, Selby PJ, Trejdosiewicz LK, Southgate J (Dec 1998). "Uroplakin gene expression by normal and neoplastic human urothelium". Am J Pathol. 153 (6): 1957–67. doi:10.1016/S0002-9440(10)65709-4. PMC 1866332. PMID 9846985.
↑ "Entrez Gene: UPK2 uroplakin 2".

Lin JH, Wu XR, Kreibich G, Sun TT (1994). "Precursor sequence, processing, and urothelium-specific expression of a major 15-kDa protein subunit of asymmetric unit membrane". J. Biol. Chem. 269 (3): 1775–84. PMID 7507484.
Wu XR, Lin JH, Walz T, et al. (1994). "Mammalian uroplakins. A group of highly conserved urothelial differentiation-related membrane proteins". J. Biol. Chem. 269 (18): 13716–24. PMID 8175808.
Yuasa T, Yoshiki T, Isono T, et al. (1999). "Expression of transitional cell-specific genes, uroplakin Ia and II, in bladder cancer: detection of circulating cancer cells in the peripheral blood of metastatic patients". Int. J. Urol. 6 (6): 286–92. doi:10.1046/j.1442-2042.1999.00064.x. PMID 10404304.
Li SM, Zhang ZT, Chan S, et al. (1999). "Detection of circulating uroplakin-positive cells in patients with transitional cell carcinoma of the bladder". J. Urol. 162 (3 Pt 1): 931–5. doi:10.1097/00005392-199909010-00093. PMID 10458411.
Ogawa K, Johansson SL, Cohen SM (1999). "Immunohistochemical analysis of uroplakins, urothelial specific proteins, in ovarian Brenner tumors, normal tissues, and benign and neoplastic lesions of the female genital tract". Am. J. Pathol. 155 (4): 1047–50. doi:10.1016/S0002-9440(10)65206-6. PMC 1867018. PMID 10514386.
Tu L, Sun TT, Kreibich G (2003). "Specific heterodimer formation is a prerequisite for uroplakins to exit from the endoplasmic reticulum". Mol. Biol. Cell. 13 (12): 4221–30. doi:10.1091/mbc.E02-04-0211. PMC 138628. PMID 12475947.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Hirata H, Hisatomi H, Kawakita M, et al. (2004). "Genetic detection for hematogenous micrometastasis in patients with various types of malignant tumors using Uroplakin II derived primers in polymerase chain reaction". Oncol. Rep. 10 (4): 963–6. doi:10.3892/or.10.4.963. PMID 12792753.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Chen F, Zeng F, Tong Q, et al. (2006). "Cloning of human uroplakin II gene from Chinese transitional cell carcinoma of bladder and construction of its eukaryotic expression vector". J. Huazhong Univ. Sci. Technol. Med. Sci. 25 (2): 188–90, 211. doi:10.1007/BF02873573. PMID 16116969.
Jenkins D, Bitner-Glindzicz M, Malcolm S, et al. (2007). "Mutation analyses of Uroplakin II in children with renal tract malformations". Nephrol. Dial. Transplant. 21 (12): 3415–21. doi:10.1093/ndt/gfl465. PMID 17012268.

This article on a gene on human chromosome 11 is a stub. You can help Wikipedia by expanding it.

[pmid9515818-1] Wu RL, Osman I, Wu XR, Lu ML, Zhang ZF, Liang FX, Hamza R, Scher H, Cordon-Cardo C, Sun TT (Apr 1998). "Uroplakin II gene is expressed in transitional cell carcinoma but not in bilharzial bladder squamous cell carcinoma: alternative pathways of bladder epithelial differentiation and tumor formation". Cancer Res. 58 (6): 1291–7. doi:10.1097/00005392-199811000-00097. PMID 9515818.

[pmid9846985-2] Lobban ED, Smith BA, Hall GD, Harnden P, Roberts P, Selby PJ, Trejdosiewicz LK, Southgate J (Dec 1998). "Uroplakin gene expression by normal and neoplastic human urothelium". Am J Pathol. 153 (6): 1957–67. doi:10.1016/S0002-9440(10)65709-4. PMC 1866332. PMID 9846985.

[entrez-3] "Entrez Gene: UPK2 uroplakin 2".

[1]

[2]

[3]

@@ Line 1: / Line 1: @@
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+{{Underlinked|date=June 2016}}
-{{PBB_Controls
+{{Infobox_gene}}
-| update_page = yes
+'''Uroplakin-2''' is a [[protein]] that in humans is encoded by the ''UPK2'' [[gene]].<ref name="pmid9515818">{{cite journal | vauthors = Wu RL, Osman I, Wu XR, Lu ML, Zhang ZF, Liang FX, Hamza R, Scher H, Cordon-Cardo C, Sun TT | title = Uroplakin II gene is expressed in transitional cell carcinoma but not in bilharzial bladder squamous cell carcinoma: alternative pathways of bladder epithelial differentiation and tumor formation | journal = Cancer Res | volume = 58 | issue = 6 | pages = 1291–7 |date=Apr 1998 | pmid = 9515818 | pmc =  | doi =  10.1097/00005392-199811000-00097}}</ref><ref name="pmid9846985">{{cite journal | vauthors = Lobban ED, Smith BA, Hall GD, Harnden P, Roberts P, Selby PJ, Trejdosiewicz LK, Southgate J | title = Uroplakin gene expression by normal and neoplastic human urothelium | journal = Am J Pathol | volume = 153 | issue = 6 | pages = 1957–67 |date=Dec 1998 | pmid = 9846985 | pmc = 1866332 | doi =10.1016/S0002-9440(10)65709-4  }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: UPK2 uroplakin 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7379| accessdate = }}</ref>
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-{{GNF_Protein_box
- | image =
- | image_source =
- | PDB =
- | Name = Uroplakin 2
- | HGNCid = 12579
- | Symbol = UPK2
- | AltSymbols =; MGC138598
- | OMIM =
- | ECnumber =
-  | Homologene = 4920
-  | MGIid = 98913
- | GeneAtlas_image1 = PBB_GE_UPK2_207862_at_tn.png
- | Function =
- | Component = {{GNF_GO|id=GO:0005783 |text = endoplasmic reticulum}} {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0030176 |text = integral to endoplasmic reticulum membrane}}
- | Process = {{GNF_GO|id=GO:0007275 |text = multicellular organismal development}} {{GNF_GO|id=GO:0016044 |text = membrane organization and biogenesis}} {{GNF_GO|id=GO:0030855 |text = epithelial cell differentiation}}
- | Orthologs = {{GNF_Ortholog_box
-    | Hs_EntrezGene = 7379
-    | Hs_Ensembl = ENSG00000110375
-    | Hs_RefseqProtein = NP_006751
-    | Hs_RefseqmRNA = NM_006760
-    | Hs_GenLoc_db =
-    | Hs_GenLoc_chr = 11
-    | Hs_GenLoc_start = 118332236
-    | Hs_GenLoc_end = 118334478
-    | Hs_Uniprot = O00526
-    | Mm_EntrezGene = 22269
-    | Mm_Ensembl = ENSMUSG00000041523
-    | Mm_RefseqmRNA = NM_009476
-    | Mm_RefseqProtein = NP_033502
-    | Mm_GenLoc_db =
-    | Mm_GenLoc_chr = 9
-    | Mm_GenLoc_start = 44203720
-    | Mm_GenLoc_end = 44205762
-    | Mm_Uniprot = Q3SXK0
-  }}
-}}
-'''Uroplakin 2''', also known as '''UPK2''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: UPK2 uroplakin 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7379| accessdate = }}</ref>
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 {{PBB_Summary
@@ Line 55: / Line 9: @@
 ==References==
-{{reflist|2}}
+{{reflist}}
 ==Further reading==
 {{refbegin | 2}}
 {{PBB_Further_reading
 | citations =
-*{{cite journal  | author=Lin JH, Wu XR, Kreibich G, Sun TT |title=Precursor sequence, processing, and urothelium-specific expression of a major 15-kDa protein subunit of asymmetric unit membrane. |journal=J. Biol. Chem. |volume=269 |issue= 3 |pages= 1775-84 |year= 1994 |pmid= 7507484 |doi=  }}
+*{{cite journal  | vauthors=Lin JH, Wu XR, Kreibich G, Sun TT |title=Precursor sequence, processing, and urothelium-specific expression of a major 15-kDa protein subunit of asymmetric unit membrane |journal=J. Biol. Chem. |volume=269 |issue= 3 |pages= 1775–84 |year= 1994 |pmid= 7507484 |doi=  }}
-*{{cite journal  | author=Wu XR, Lin JH, Walz T, ''et al.'' |title=Mammalian uroplakins. A group of highly conserved urothelial differentiation-related membrane proteins. |journal=J. Biol. Chem. |volume=269 |issue= 18 |pages= 13716-24 |year= 1994 |pmid= 8175808 |doi=  }}
+*{{cite journal   |vauthors=Wu XR, Lin JH, Walz T, etal |title=Mammalian uroplakins. A group of highly conserved urothelial differentiation-related membrane proteins |journal=J. Biol. Chem. |volume=269 |issue= 18 |pages= 13716–24 |year= 1994 |pmid= 8175808 |doi=  }}
-*{{cite journal  | author=Wu RL, Osman I, Wu XR, ''et al.'' |title=Uroplakin II gene is expressed in transitional cell carcinoma but not in bilharzial bladder squamous cell carcinoma: alternative pathways of bladder epithelial differentiation and tumor formation. |journal=Cancer Res. |volume=58 |issue= 6 |pages= 1291-7 |year= 1998 |pmid= 9515818 |doi=  }}
+*{{cite journal   |vauthors=Yuasa T, Yoshiki T, Isono T, etal |title=Expression of transitional cell-specific genes, uroplakin Ia and II, in bladder cancer: detection of circulating cancer cells in the peripheral blood of metastatic patients |journal=Int. J. Urol. |volume=6 |issue= 6 |pages= 286–92 |year= 1999 |pmid= 10404304 |doi=10.1046/j.1442-2042.1999.00064.x  }}
-*{{cite journal  | author=Lobban ED, Smith BA, Hall GD, ''et al.'' |title=Uroplakin gene expression by normal and neoplastic human urothelium. |journal=Am. J. Pathol. |volume=153 |issue= 6 |pages= 1957-67 |year= 1998 |pmid= 9846985 |doi=  }}
+*{{cite journal   |vauthors=Li SM, Zhang ZT, Chan S, etal |title=Detection of circulating uroplakin-positive cells in patients with transitional cell carcinoma of the bladder |journal=J. Urol. |volume=162 |issue= 3 Pt 1 |pages= 931–5 |year= 1999 |pmid= 10458411 |doi=10.1097/00005392-199909010-00093  }}
-*{{cite journal  | author=Yuasa T, Yoshiki T, Isono T, ''et al.'' |title=Expression of transitional cell-specific genes, uroplakin Ia and II, in bladder cancer: detection of circulating cancer cells in the peripheral blood of metastatic patients. |journal=Int. J. Urol. |volume=6 |issue= 6 |pages= 286-92 |year= 1999 |pmid= 10404304 |doi=  }}
+*{{cite journal  | vauthors=Ogawa K, Johansson SL, Cohen SM |title=Immunohistochemical analysis of uroplakins, urothelial specific proteins, in ovarian Brenner tumors, normal tissues, and benign and neoplastic lesions of the female genital tract |journal=Am. J. Pathol. |volume=155 |issue= 4 |pages= 1047–50 |year= 1999 |pmid= 10514386 |doi=  10.1016/S0002-9440(10)65206-6| pmc=1867018  }}
-*{{cite journal  | author=Li SM, Zhang ZT, Chan S, ''et al.'' |title=Detection of circulating uroplakin-positive cells in patients with transitional cell carcinoma of the bladder. |journal=J. Urol. |volume=162 |issue= 3 Pt 1 |pages= 931-5 |year= 1999 |pmid= 10458411 |doi=  }}
+*{{cite journal  | vauthors=Tu L, Sun TT, Kreibich G |title=Specific heterodimer formation is a prerequisite for uroplakins to exit from the endoplasmic reticulum |journal=Mol. Biol. Cell |volume=13 |issue= 12 |pages= 4221–30 |year= 2003 |pmid= 12475947 |doi= 10.1091/mbc.E02-04-0211  | pmc=138628 }}
-*{{cite journal  | author=Ogawa K, Johansson SL, Cohen SM |title=Immunohistochemical analysis of uroplakins, urothelial specific proteins, in ovarian Brenner tumors, normal tissues, and benign and neoplastic lesions of the female genital tract. |journal=Am. J. Pathol. |volume=155 |issue= 4 |pages= 1047-50 |year= 1999 |pmid= 10514386 |doi=  }}
+*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 }}
-*{{cite journal  | author=Tu L, Sun TT, Kreibich G |title=Specific heterodimer formation is a prerequisite for uroplakins to exit from the endoplasmic reticulum. |journal=Mol. Biol. Cell |volume=13 |issue= 12 |pages= 4221-30 |year= 2003 |pmid= 12475947 |doi= 10.1091/mbc.E02-04-0211 }}
+*{{cite journal   |vauthors=Hirata H, Hisatomi H, Kawakita M, etal |title=Genetic detection for hematogenous micrometastasis in patients with various types of malignant tumors using Uroplakin II derived primers in polymerase chain reaction |journal=Oncol. Rep. |volume=10 |issue= 4 |pages= 963–6 |year= 2004 |pmid= 12792753 |doi=  10.3892/or.10.4.963}}
-*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
+*{{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504  | pmc=528928 }}
-*{{cite journal  | author=Hirata H, Hisatomi H, Kawakita M, ''et al.'' |title=Genetic detection for hematogenous micrometastasis in patients with various types of malignant tumors using Uroplakin II derived primers in polymerase chain reaction. |journal=Oncol. Rep. |volume=10 |issue= 4 |pages= 963-6 |year= 2004 |pmid= 12792753 |doi=  }}
+*{{cite journal   |vauthors=Chen F, Zeng F, Tong Q, etal |title=Cloning of human uroplakin II gene from Chinese transitional cell carcinoma of bladder and construction of its eukaryotic expression vector |journal=J. Huazhong Univ. Sci. Technol. Med. Sci. |volume=25 |issue= 2 |pages= 188–90, 211 |year= 2006 |pmid= 16116969 |doi=10.1007/BF02873573  }}
-*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
+*{{cite journal   |vauthors=Jenkins D, Bitner-Glindzicz M, Malcolm S, etal |title=Mutation analyses of Uroplakin II in children with renal tract malformations |journal=Nephrol. Dial. Transplant. |volume=21 |issue= 12 |pages= 3415–21 |year= 2007 |pmid= 17012268 |doi= 10.1093/ndt/gfl465 }}
-*{{cite journal  | author=Chen F, Zeng F, Tong Q, ''et al.'' |title=Cloning of human uroplakin II gene from Chinese transitional cell carcinoma of bladder and construction of its eukaryotic expression vector. |journal=J. Huazhong Univ. Sci. Technol. Med. Sci. |volume=25 |issue= 2 |pages= 188-90, 211 |year= 2006 |pmid= 16116969 |doi=  }}
-*{{cite journal  | author=Jenkins D, Bitner-Glindzicz M, Malcolm S, ''et al.'' |title=Mutation analyses of Uroplakin II in children with renal tract malformations. |journal=Nephrol. Dial. Transplant. |volume=21 |issue= 12 |pages= 3415-21 |year= 2007 |pmid= 17012268 |doi= 10.1093/ndt/gfl465 }}
 }}
 {{refend}}
-{{protein-stub}}
+<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
-{{WikiDoc Sources}}
+{{PBB_Controls
+| update_page = yes
+| require_manual_inspection = no
+| update_protein_box = yes
+| update_summary = yes
+| update_citations = yes
+}}
+{{gene-11-stub}}
+[[Category:Uroplakins]]

UPK2: Difference between revisions

Latest revision as of 09:51, 17 September 2017

References

Further reading

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