UQCRC1: Difference between revisions

Jump to navigation Jump to search
VisualWikitext
m (Robot: Automated text replacement (-{{reflist}} +{{reflist|2}}, -<references /> +{{reflist|2}}, -{{WikiDoc Cardiology Network Infobox}} +))
 
m (Bot: HTTP→HTTPS)
 
Line 1: Line 1:
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''Cytochrome b-c1 complex subunit 1, mitochondrial''' is a [[protein]] that in humans is encoded by the ''UQCRC1'' [[gene]].<ref name="pmid8407948">{{cite journal |vauthors=Hoffman GG, Lee S, Christiano AM, Chung-Honet LC, Cheng W, Katchman S, Uitto J, Greenspan DS | title = Complete coding sequence, intron/exon organization, and chromosomal location of the gene for the core I protein of human ubiquinol-cytochrome c reductase | journal = J Biol Chem | volume = 268 | issue = 28 | pages = 21113–9 |date=Nov 1993 | pmid = 8407948 | pmc =  | doi =  }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: UQCRC1 ubiquinol-cytochrome c reductase core protein I| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7384| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
 
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_UQCRC1_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1be3.
| PDB = {{PDB2|1be3}}, {{PDB2|1bgy}}, {{PDB2|1l0l}}, {{PDB2|1l0n}}, {{PDB2|1ntk}}, {{PDB2|1ntm}}, {{PDB2|1ntz}}, {{PDB2|1nu1}}, {{PDB2|1pp9}}, {{PDB2|1ppj}}, {{PDB2|1qcr}}, {{PDB2|1sqq}}, {{PDB2|1sqv}}, {{PDB2|1sqx}}, {{PDB2|2a06}}, {{PDB2|2fyu}}
| Name = Ubiquinol-cytochrome c reductase core protein I
| HGNCid = 12585
| Symbol = UQCRC1
| AltSymbols =; D3S3191
| OMIM = 191328
| ECnumber = 
| Homologene = 2525
| MGIid = 107876
| GeneAtlas_image1 = PBB_GE_UQCRC1_201903_at_tn.png
| Function = {{GNF_GO|id=GO:0008121 |text = ubiquinol-cytochrome-c reductase activity}} {{GNF_GO|id=GO:0016491 |text = oxidoreductase activity}}
| Component = {{GNF_GO|id=GO:0005739 |text = mitochondrion}} {{GNF_GO|id=GO:0005746 |text = mitochondrial respiratory chain}} {{GNF_GO|id=GO:0016020 |text = membrane}}
  | Process = {{GNF_GO|id=GO:0006118 |text = electron transport}} {{GNF_GO|id=GO:0006119 |text = oxidative phosphorylation}} {{GNF_GO|id=GO:0006810 |text = transport}} {{GNF_GO|id=GO:0009060 |text = aerobic respiration}}
  | Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 7384
    | Hs_Ensembl = ENSG00000010256
    | Hs_RefseqProtein = NP_003356
    | Hs_RefseqmRNA = NM_003365
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 3
    | Hs_GenLoc_start = 48611440
    | Hs_GenLoc_end = 48622474
    | Hs_Uniprot = P31930
    | Mm_EntrezGene = 22273
    | Mm_Ensembl = ENSMUSG00000025651
    | Mm_RefseqmRNA = NM_025407
    | Mm_RefseqProtein = NP_079683
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 9
    | Mm_GenLoc_start = 108793553
    | Mm_GenLoc_end = 108806581
    | Mm_Uniprot = Q3THM1
  }}
}}
'''Ubiquinol-cytochrome c reductase core protein I''', also known as '''UQCRC1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: UQCRC1 ubiquinol-cytochrome c reductase core protein I| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7384| accessdate = }}</ref>


Its gene product is a subunit of the respiratory chain protein [[ubiquinol-cytochrome-c reductase|Ubiquinol Cytochrome c Reductase]] (UQCR, [[Complex III]] or Cytochrome bc1 complex), which consists of the products of one mitochondrially encoded gene, [[MT-CYB|MTCYTB]] (mitochondrial [[cytochrome b]]) and ten nuclear genes: '''UQCRC1''', [[UQCRC2]], [[Cytochrome C1|Cytochrome c1]], [[UQCRFS1]] ([[Rieske protein]]), [[UQCRB]], "11kDa protein", [[UQCRH]] (cyt c1 Hinge protein), Rieske Protein presequence, "cyt. c1 associated protein", and Rieske-associated protein.
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
{{PBB_Summary
Line 55: Line 10:


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Suzuki H, Hosokawa Y, Nishikimi M, Ozawa T |title=Existence of common homologous elements in the transcriptional regulatory regions of human nuclear genes and mitochondrial gene for the oxidative phosphorylation system. |journal=J. Biol. Chem. |volume=266 |issue= 4 |pages= 2333-8 |year= 1991 |pmid= 1846623 |doi=  }}
*{{cite journal  |vauthors=Suzuki H, Hosokawa Y, Nishikimi M, Ozawa T |title=Existence of common homologous elements in the transcriptional regulatory regions of human nuclear genes and mitochondrial gene for the oxidative phosphorylation system. |journal=J. Biol. Chem. |volume=266 |issue= 4 |pages= 2333–8 |year= 1991 |pmid= 1846623 |doi=  }}
*{{cite journal  | author=Broger C, Nałecz MJ, Azzi A |title=Interaction of cytochrome c with cytochrome bc1 complex of the mitochondrial respiratory chain. |journal=Biochim. Biophys. Acta |volume=592 |issue= 3 |pages= 519-27 |year= 1980 |pmid= 6251869 |doi=  }}
*{{cite journal  |vauthors=Broger C, Nałecz MJ, Azzi A |title=Interaction of cytochrome c with cytochrome bc1 complex of the mitochondrial respiratory chain. |journal=Biochim. Biophys. Acta |volume=592 |issue= 3 |pages= 519–27 |year= 1980 |pmid= 6251869 |doi=10.1016/0005-2728(80)90096-1 }}
*{{cite journal  | author=Islam MM, Tanaka M, Suzuki H, ''et al.'' |title=A complete cDNA sequence for core I protein subunit of human ubiquinol-cytochrome c reductase. |journal=Biochem. Mol. Biol. Int. |volume=33 |issue= 2 |pages= 410 |year= 1994 |pmid= 7951059 |doi=  }}
*{{cite journal  | author=Islam MM |title=A complete cDNA sequence for core I protein subunit of human ubiquinol-cytochrome c reductase |journal=Biochem. Mol. Biol. Int. |volume=33 |issue= 2 |pages= 410 |year= 1994 |pmid= 7951059 |doi=  |name-list-format=vanc| author2=Tanaka M | author3=Suzuki H | display-authors=3  | last4=Torii  | first4=K  | last5=Hattori  | first5=N  | last6=Ozawa  | first6=T  }}
*{{cite journal  | author=Islam MM, Tanaka M, Suzuki H, ''et al.'' |title=A complete cDNA sequence for core I protein subunit of human ubiquinol-cytochrome c reductase. |journal=Biochem. Mol. Biol. Int. |volume=33 |issue= 4 |pages= 815 |year= 1995 |pmid= 7981668 |doi=  }}
*{{cite journal  | author=Islam MM |title=A complete cDNA sequence for core I protein subunit of human ubiquinol-cytochrome c reductase |journal=Biochem. Mol. Biol. Int. |volume=33 |issue= 4 |pages= 815 |year= 1995 |pmid= 7981668 |doi=  |name-list-format=vanc| author2=Tanaka M | author3=Suzuki H  | display-authors=3  | last4=Torii  | first4=K  | last5=Hattori  | first5=N  | last6=Ozawa  | first6=T }}
*{{cite journal  | author=Islam MM, Tanaka M, Suzuki H, ''et al.'' |title=A complete cDNA sequence for core I protein subunit of human ubiquinol-cytochrome c reductase. |journal=Biochem. Mol. Biol. Int. |volume=32 |issue= 5 |pages= 797-805 |year= 1994 |pmid= 8069229 |doi=  }}
*{{cite journal  | author=Islam MM |title=A complete cDNA sequence for core I protein subunit of human ubiquinol-cytochrome c reductase |journal=Biochem. Mol. Biol. Int. |volume=32 |issue= 5 |pages= 797–805 |year= 1994 |pmid= 8069229 |doi=  |name-list-format=vanc| author2=Tanaka M | author3=Suzuki H  | display-authors=3  | last4=Torii  | first4=K  | last5=Hattori  | first5=N  | last6=Ozawa  | first6=T }}
*{{cite journal | author=Hughes GJ, Frutiger S, Paquet N, ''et al.'' |title=Human liver protein map: update 1993. |journal=Electrophoresis |volume=14 |issue= 11 |pages= 1216-22 |year= 1994 |pmid= 8313870 |doi=  }}
*{{cite journal  | author=Hughes GJ |title=Human liver protein map: update 1993 |journal=Electrophoresis |volume=14 |issue= 11 |pages= 1216–22 |year= 1994 |pmid= 8313870 |doi=10.1002/elps.11501401181 |name-list-format=vanc| author2=Frutiger S  | author3=Paquet N  | display-authors=3  | last4=Pasquali  | first4=Christian  | last5=Sanchez  | first5=Jean-Charles  | last6=Tissot  | first6=Jean-Daniel  | last7=Bairoch | first7=Amos | last8=Appel  | first8=Ron D. | last9=Hochstrasser  | first9=Denis F.  }}
*{{cite journal  | author=Hoffman GG, Lee S, Christiano AM, ''et al.'' |title=Complete coding sequence, intron/exon organization, and chromosomal location of the gene for the core I protein of human ubiquinol-cytochrome c reductase. |journal=J. Biol. Chem. |volume=268 |issue= 28 |pages= 21113-9 |year= 1993 |pmid= 8407948 |doi=  }}
*{{cite journal  | author=Hillier LD |title=Generation and analysis of 280,000 human expressed sequence tags |journal=Genome Res. |volume=6 |issue= 9 |pages= 807–28 |year= 1997 |pmid= 8889549 |doi=10.1101/gr.6.9.807 |name-list-format=vanc| author2=Lennon G  | author3=Becker M  | display-authors=3  | last4=Bonaldo  | first4=M F  | last5=Chiapelli  | first5=B  | last6=Chissoe  | first6=S  | last7=Dietrich  | first7=N  | last8=Dubuque  | first8=T  | last9=Favello  | first9=A  }}
*{{cite journal | author=Hillier LD, Lennon G, Becker M, ''et al.'' |title=Generation and analysis of 280,000 human expressed sequence tags. |journal=Genome Res. |volume=6 |issue= 9 |pages= 807-28 |year= 1997 |pmid= 8889549 |doi=  }}
*{{cite journal  | author=Valnot I |title=A mitochondrial cytochrome b mutation but no mutations of nuclearly encoded subunits in ubiquinol cytochrome c reductase (complex III) deficiency |journal=Hum. Genet. |volume=104 |issue= 6 |pages= 460–6 |year= 1999 |pmid= 10453733 |doi=10.1007/s004390050988 |name-list-format=vanc| author2=Kassis J  | author3=Chretien D  | display-authors=3  | last4=De Lonlay  | first4=Pascale  | last5=Parfait  | first5=B&#x000E9;Atrice  | last6=Munnich | first6=Arnold  | last7=Kachaner  | first7=Jean  | last8=Rustin  | first8=Pierre  | last9=r&#x000f6;Tig  | first9=Agn&#x000E8;s  }}
*{{cite journal  | author=Valnot I, Kassis J, Chretien D, ''et al.'' |title=A mitochondrial cytochrome b mutation but no mutations of nuclearly encoded subunits in ubiquinol cytochrome c reductase (complex III) deficiency. |journal=Hum. Genet. |volume=104 |issue= 6 |pages= 460-6 |year= 1999 |pmid= 10453733 |doi=  }}
*{{cite journal  | author=Hu WH |title=Identification and characterization of a novel Nogo-interacting mitochondrial protein (NIMP) |journal=J. Neurochem. |volume=81 |issue= 1 |pages= 36–45 |year= 2002 |pmid= 12067236 |doi=10.1046/j.1471-4159.2002.00788.x |name-list-format=vanc| author2=Hausmann ON  | author3=Yan MS  | display-authors=3  | last4=Walters  | first4=Winston M.  | last5=Wong  | first5=Paul K. Y.  | last6=Bethea  | first6=John R. }}
*{{cite journal  | author=Hu WH, Hausmann ON, Yan MS, ''et al.'' |title=Identification and characterization of a novel Nogo-interacting mitochondrial protein (NIMP). |journal=J. Neurochem. |volume=81 |issue= 1 |pages= 36-45 |year= 2002 |pmid= 12067236 |doi=  }}
*{{cite journal  | author=Strausberg RL |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241  |name-list-format=vanc| author2=Feingold EA  | author3=Grouse LH  | display-authors=3  | last4=Derge  | first4=JG  | last5=Klausner  | first5=RD  | last6=Collins  | first6=FS  | last7=Wagner  | first7=L  | last8=Shenmen  | first8=CM  | last9=Schuler  | first9=GD }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  |vauthors=Aboulaich N, Vainonen JP, Strålfors P, Vener AV |title=Vectorial proteomics reveal targeting, phosphorylation and specific fragmentation of polymerase I and transcript release factor (PTRF) at the surface of caveolae in human adipocytes |journal=Biochem. J. |volume=383 |issue= Pt 2 |pages= 237–48 |year= 2005 |pmid= 15242332 |doi= 10.1042/BJ20040647  | pmc=1134064 }}
*{{cite journal | author=Aboulaich N, Vainonen JP, Strålfors P, Vener AV |title=Vectorial proteomics reveal targeting, phosphorylation and specific fragmentation of polymerase I and transcript release factor (PTRF) at the surface of caveolae in human adipocytes. |journal=Biochem. J. |volume=383 |issue= Pt 2 |pages= 237-48 |year= 2005 |pmid= 15242332 |doi= 10.1042/BJ20040647 }}
*{{cite journal  | author=Gerhard DS |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504  | pmc=528928  |name-list-format=vanc| author2=Wagner L  | author3=Feingold EA  | display-authors=3  | last4=Shenmen  | first4=CM  | last5=Grouse  | first5=LH  | last6=Schuler  | first6=G  | last7=Klein  | first7=SL  | last8=Old  | first8=S  | last9=Rasooly  | first9=R }}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  |vauthors=Wen JJ, Garg N |title=Oxidative modification of mitochondrial respiratory complexes in response to the stress of Trypanosoma cruzi infection |journal=Free Radic. Biol. Med. |volume=37 |issue= 12 |pages= 2072–81 |year= 2005 |pmid= 15544925 |doi= 10.1016/j.freeradbiomed.2004.09.011 }}
*{{cite journal | author=Wen JJ, Garg N |title=Oxidative modification of mitochondrial respiratory complexes in response to the stress of Trypanosoma cruzi infection. |journal=Free Radic. Biol. Med. |volume=37 |issue= 12 |pages= 2072-81 |year= 2005 |pmid= 15544925 |doi= 10.1016/j.freeradbiomed.2004.09.011 }}
*{{cite journal  | author=Rual JF |title=Towards a proteome-scale map of the human protein-protein interaction network |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209  |name-list-format=vanc| author2=Venkatesan K  | author3=Hao T  | display-authors=3  | last4=Hirozane-Kishikawa  | first4=Tomoko  | last5=Dricot  | first5=Amélie  | last6=Li  | first6=Ning  | last7=Berriz  | first7=Gabriel F.  | last8=Gibbons  | first8=Francis D.  | last9=Dreze  | first9=Matija }}
*{{cite journal | author=Rual JF, Venkatesan K, Hao T, ''et al.'' |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173-8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
*{{cite journal  | author=Kulawiec M |title=Proteomic analysis of mitochondria-to-nucleus retrograde response in human cancer |journal=Cancer Biol. Ther. |volume=5 |issue= 8 |pages= 967–75 |year= 2007 |pmid= 16775426 |doi=  10.4161/cbt.5.8.2880|name-list-format=vanc| author2=Arnouk H  | author3=Desouki MM  | display-authors=3  | last4=Kazim  | first4=L  | last5=Still  | first5=I  | last6=Singh  | first6=KK  }}
*{{cite journal | author=Kulawiec M, Arnouk H, Desouki MM, ''et al.'' |title=Proteomic analysis of mitochondria-to-nucleus retrograde response in human cancer. |journal=Cancer Biol. Ther. |volume=5 |issue= 8 |pages= 967-75 |year= 2007 |pmid= 16775426 |doi=  }}
*{{cite journal  | author=Ewing RM |title=Large-scale mapping of human protein-protein interactions by mass spectrometry |journal=Mol. Syst. Biol. |volume=3 |issue=  1|pages= 89 |year= 2007 |pmid= 17353931 |doi= 10.1038/msb4100134  | pmc=1847948  |name-list-format=vanc| author2=Chu P  | author3=Elisma F  | display-authors=3  | last4=Li  | first4=Hongyan  | last5=Taylor  | first5=Paul  | last6=Climie  | first6=Shane  | last7=McBroom-Cerajewski  | first7=Linda  | last8=Robinson  | first8=Mark D  | last9=O'Connor | first9=Liam }}
*{{cite journal  | author=Ewing RM, Chu P, Elisma F, ''et al.'' |title=Large-scale mapping of human protein-protein interactions by mass spectrometry. |journal=Mol. Syst. Biol. |volume=3 |issue= |pages= 89 |year= 2007 |pmid= 17353931 |doi= 10.1038/msb4100134 }}
}}
}}
{{refend}}
{{refend}}
{{PDB Gallery|geneid=7384}}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


{{protein-stub}}
{{gene-3-stub}}
{{WikiDoc Sources}}

Latest revision as of 09:52, 17 September 2017

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

n/a

n/a

Ensembl

n/a

n/a

UniProt

n/a

n/a

RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

n/a

Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Cytochrome b-c1 complex subunit 1, mitochondrial is a protein that in humans is encoded by the UQCRC1 gene.[1][2]

Its gene product is a subunit of the respiratory chain protein Ubiquinol Cytochrome c Reductase (UQCR, Complex III or Cytochrome bc1 complex), which consists of the products of one mitochondrially encoded gene, MTCYTB (mitochondrial cytochrome b) and ten nuclear genes: UQCRC1, UQCRC2, Cytochrome c1, UQCRFS1 (Rieske protein), UQCRB, "11kDa protein", UQCRH (cyt c1 Hinge protein), Rieske Protein presequence, "cyt. c1 associated protein", and Rieske-associated protein.


References

  1. ↑ Hoffman GG, Lee S, Christiano AM, Chung-Honet LC, Cheng W, Katchman S, Uitto J, Greenspan DS (Nov 1993). "Complete coding sequence, intron/exon organization, and chromosomal location of the gene for the core I protein of human ubiquinol-cytochrome c reductase". J Biol Chem. 268 (28): 21113–9. PMID 8407948.
  2. ↑ "Entrez Gene: UQCRC1 ubiquinol-cytochrome c reductase core protein I".

Further reading



Retrieved from "https://www.wikidoc.org/index.php?title=UQCRC1&oldid=1413181"