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{{Infobox_gene}}
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'''WD repeat-containing protein 5''' is a [[protein]] that in humans is encoded by the ''WDR5'' [[gene]].<ref name="pmid11551928">{{cite journal |vauthors=Gori F, Divieti P, Demay MB | title = Cloning and characterization of a novel WD-40 repeat protein that dramatically accelerates osteoblastic differentiation | journal = J Biol Chem | volume = 276 | issue = 49 | pages = 46515–22 |date=Dec 2001 | pmid = 11551928 | pmc =  | doi = 10.1074/jbc.M105757200 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: WDR5 WD repeat domain 5| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=11091| accessdate = }}</ref>
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_WDR5_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 2cnx.
| PDB = {{PDB2|2cnx}}, {{PDB2|2co0}}, {{PDB2|2g99}}, {{PDB2|2g9a}}, {{PDB2|2gnq}}, {{PDB2|2h13}}, {{PDB2|2h14}}, {{PDB2|2h68}}, {{PDB2|2h6k}}, {{PDB2|2h6n}}, {{PDB2|2h6q}}, {{PDB2|2h9l}}, {{PDB2|2h9m}}, {{PDB2|2h9n}}, {{PDB2|2h9p}}, {{PDB2|2o9k}}
| Name = WD repeat domain 5
| HGNCid = 12757
| Symbol = WDR5
| AltSymbols =; BIG-3; SWD3
| OMIM = 609012
| ECnumber =
| Homologene = 59931
| MGIid = 2155884
  | GeneAtlas_image1 = PBB_GE_WDR5_gnf1h08370_at_tn.png
| Function = {{GNF_GO|id=GO:0005515 |text = protein binding}}  
| Component = {{GNF_GO|id=GO:0005622 |text = intracellular}}
| Process = {{GNF_GO|id=GO:0001501 |text = skeletal development}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 11091
    | Hs_Ensembl = ENSG00000196363
    | Hs_RefseqProtein = NP_060058
    | Hs_RefseqmRNA = NM_017588
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 9
    | Hs_GenLoc_start = 135991031
    | Hs_GenLoc_end = 136014914
    | Hs_Uniprot = P61964
    | Mm_EntrezGene = 140858
    | Mm_Ensembl = ENSMUSG00000026917
    | Mm_RefseqmRNA = NM_080848
    | Mm_RefseqProtein = NP_543124
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 2
    | Mm_GenLoc_start = 27216188
    | Mm_GenLoc_end = 27358544
    | Mm_Uniprot = Q3UNQ3
  }}
}}
'''WD repeat domain 5''', also known as '''WDR5''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: WDR5 WD repeat domain 5| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=11091| accessdate = }}</ref>


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{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This protein contains 7 WD repeats. Alternatively spliced transcript variants encoding the same protein have been identified.<ref name="entrez">{{cite web | title = Entrez Gene: WDR5 WD repeat domain 5| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=11091| accessdate = }}</ref>
| summary_text = This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This protein contains 7 WD repeats. Alternatively spliced transcript variants encoding the same protein have been identified.<ref name="entrez"/>
}}
}}
==Interactions==
WDR5 has been shown to [[Protein-protein interaction|interact]] with [[Host cell factor C1]]<ref name=pmid15199122>{{cite journal |last=Yokoyama |first=Akihiko |authorlink= |author2=Wang Zhong |author3=Wysocka Joanna |author4=Sanyal Mrinmoy |author5=Aufiero Deborah J |author6=Kitabayashi Issay |author7=Herr Winship |author8=Cleary Michael L  |date=Jul 2004 |title=Leukemia proto-oncoprotein MLL forms a SET1-like histone methyltransferase complex with menin to regulate Hox gene expression |journal=Mol. Cell. Biol. |volume=24 |issue=13 |pages=5639–49 |publisher= |location = United States| issn = 0270-7306| pmid = 15199122 |doi = 10.1128/MCB.24.13.5639-5649.2004 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |pmc=480881 }}</ref><ref name=pmid12670868>{{cite journal |last=Wysocka |first=Joanna |authorlink= |author2=Myers Michael P |author3=Laherty Carol D |author4=Eisenman Robert N |author5=Herr Winship  |date=Apr 2003 |title=Human Sin3 deacetylase and trithorax-related Set1/Ash2 histone H3-K4 methyltransferase are tethered together selectively by the cell-proliferation factor HCF-1 |journal=Genes Dev. |volume=17 |issue=7 |pages=896–911 |publisher= |location = United States| issn = 0890-9369| pmid = 12670868 |doi = 10.1101/gad.252103 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |pmc=196026 }}</ref> and [[MLL (gene)|MLL]].<ref name=pmid15199122/> It also interacts with the [[long non-coding RNA]] [[HOTTIP]].<ref name="pmid21423168">{{cite journal |vauthors=Wang KC, Yang YW, Liu B, Sanyal A, Corces-Zimmerman R, Chen Y, etal | title=A long noncoding RNA maintains active chromatin to coordinate homeotic gene expression. | journal=Nature | year= 2011 | volume= 472 | issue= 7341 | pages= 120–4 | pmid=21423168 | doi=10.1038/nature09819 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=21423168  }}</ref>
WDR5 is a key determinant for [[MYC]] recruitment to [[chromatin]]<ref>{{cite journal | last1 = Thomas | first1 = L. R. | last2 = Tansey | first2 = W. P. | year = 2015 | title = Interaction with WDR5 Promotes Target Gene Recognition and Tumorigenesis by MYC | url = | journal = Molecular Cell | volume = 58 | issue = 3| pages = 1–13 | doi = 10.1016/j.molcel.2015.02.028 | pmid=25818646 | pmc=4427524}}</ref>


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal | author=Gori F, Divieti P, Demay MB |title=Cloning and characterization of a novel WD-40 repeat protein that dramatically accelerates osteoblastic differentiation. |journal=J. Biol. Chem. |volume=276 |issue= 49 |pages= 46515-22 |year= 2002 |pmid= 11551928 |doi= 10.1074/jbc.M105757200 }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal   |vauthors=Wysocka J, Myers MP, Laherty CD, etal |title=Human Sin3 deacetylase and trithorax-related Set1/Ash2 histone H3-K4 methyltransferase are tethered together selectively by the cell-proliferation factor HCF-1. |journal=Genes Dev. |volume=17 |issue= 7 |pages= 896–911 |year= 2003 |pmid= 12670868 |doi= 10.1101/gad.252103 | pmc=196026 }}
*{{cite journal | author=Wysocka J, Myers MP, Laherty CD, ''et al.'' |title=Human Sin3 deacetylase and trithorax-related Set1/Ash2 histone H3-K4 methyltransferase are tethered together selectively by the cell-proliferation factor HCF-1. |journal=Genes Dev. |volume=17 |issue= 7 |pages= 896-911 |year= 2003 |pmid= 12670868 |doi= 10.1101/gad.252103 }}
*{{cite journal  |vauthors=Gori F, Demay MB |title=BIG-3, a novel WD-40 repeat protein, is expressed in the developing growth plate and accelerates chondrocyte differentiation in vitro. |journal=Endocrinology |volume=145 |issue= 3 |pages= 1050–4 |year= 2004 |pmid= 14657013 |doi= 10.1210/en.2003-1314 }}
*{{cite journal  | author=Gori F, Demay MB |title=BIG-3, a novel WD-40 repeat protein, is expressed in the developing growth plate and accelerates chondrocyte differentiation in vitro. |journal=Endocrinology |volume=145 |issue= 3 |pages= 1050-4 |year= 2004 |pmid= 14657013 |doi= 10.1210/en.2003-1314 }}
*{{cite journal   |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal   |vauthors=Yokoyama A, Wang Z, Wysocka J, etal |title=Leukemia proto-oncoprotein MLL forms a SET1-like histone methyltransferase complex with menin to regulate Hox gene expression. |journal=Mol. Cell. Biol. |volume=24 |issue= 13 |pages= 5639–49 |year= 2004 |pmid= 15199122 |doi= 10.1128/MCB.24.13.5639-5649.2004 | pmc=480881 }}
*{{cite journal | author=Yokoyama A, Wang Z, Wysocka J, ''et al.'' |title=Leukemia proto-oncoprotein MLL forms a SET1-like histone methyltransferase complex with menin to regulate Hox gene expression. |journal=Mol. Cell. Biol. |volume=24 |issue= 13 |pages= 5639-49 |year= 2004 |pmid= 15199122 |doi= 10.1128/MCB.24.13.5639-5649.2004 }}
*{{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal   |vauthors=Andersen JS, Lam YW, Leung AK, etal |title=Nucleolar proteome dynamics. |journal=Nature |volume=433 |issue= 7021 |pages= 77–83 |year= 2005 |pmid= 15635413 |doi= 10.1038/nature03207 }}
*{{cite journal | author=Andersen JS, Lam YW, Leung AK, ''et al.'' |title=Nucleolar proteome dynamics. |journal=Nature |volume=433 |issue= 7021 |pages= 77-83 |year= 2005 |pmid= 15635413 |doi= 10.1038/nature03207 }}
*{{cite journal   |vauthors=Wysocka J, Swigut T, Milne TA, etal |title=WDR5 associates with histone H3 methylated at K4 and is essential for H3 K4 methylation and vertebrate development. |journal=Cell |volume=121 |issue= 6 |pages= 859–72 |year= 2005 |pmid= 15960974 |doi= 10.1016/j.cell.2005.03.036 }}
*{{cite journal | author=Wysocka J, Swigut T, Milne TA, ''et al.'' |title=WDR5 associates with histone H3 methylated at K4 and is essential for H3 K4 methylation and vertebrate development. |journal=Cell |volume=121 |issue= 6 |pages= 859-72 |year= 2005 |pmid= 15960974 |doi= 10.1016/j.cell.2005.03.036 }}
*{{cite journal   |vauthors=Dou Y, Milne TA, Tackett AJ, etal |title=Physical association and coordinate function of the H3 K4 methyltransferase MLL1 and the H4 K16 acetyltransferase MOF. |journal=Cell |volume=121 |issue= 6 |pages= 873–85 |year= 2005 |pmid= 15960975 |doi= 10.1016/j.cell.2005.04.031 }}
*{{cite journal | author=Dou Y, Milne TA, Tackett AJ, ''et al.'' |title=Physical association and coordinate function of the H3 K4 methyltransferase MLL1 and the H4 K16 acetyltransferase MOF. |journal=Cell |volume=121 |issue= 6 |pages= 873-85 |year= 2005 |pmid= 15960975 |doi= 10.1016/j.cell.2005.04.031 }}
*{{cite journal   |vauthors=Rual JF, Venkatesan K, Hao T, etal |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
*{{cite journal | author=Rual JF, Venkatesan K, Hao T, ''et al.'' |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173-8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
*{{cite journal  |vauthors=Gori F, Friedman L, Demay MB |title=Wdr5, a novel WD repeat protein, regulates osteoblast and chondrocyte differentiation in vivo. |journal=Journal of musculoskeletal & neuronal interactions |volume=5 |issue= 4 |pages= 338–9 |year= 2006 |pmid= 16340128 |doi=  }}
*{{cite journal  | author=Gori F, Friedman L, Demay MB |title=Wdr5, a novel WD repeat protein, regulates osteoblast and chondrocyte differentiation in vivo. |journal=Journal of musculoskeletal & neuronal interactions |volume=5 |issue= 4 |pages= 338-9 |year= 2006 |pmid= 16340128 |doi=  }}
*{{cite journal   |vauthors=Lim J, Hao T, Shaw C, etal |title=A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration. |journal=Cell |volume=125 |issue= 4 |pages= 801–14 |year= 2006 |pmid= 16713569 |doi= 10.1016/j.cell.2006.03.032 }}
*{{cite journal | author=Lim J, Hao T, Shaw C, ''et al.'' |title=A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration. |journal=Cell |volume=125 |issue= 4 |pages= 801-14 |year= 2006 |pmid= 16713569 |doi= 10.1016/j.cell.2006.03.032 }}
*{{cite journal   |vauthors=Ruthenburg AJ, Wang W, Graybosch DM, etal |title=Histone H3 recognition and presentation by the WDR5 module of the MLL1 complex. |journal=Nat. Struct. Mol. Biol. |volume=13 |issue= 8 |pages= 704–12 |year= 2006 |pmid= 16829959 |doi= 10.1038/nsmb1119 }}
*{{cite journal | author=Ruthenburg AJ, Wang W, Graybosch DM, ''et al.'' |title=Histone H3 recognition and presentation by the WDR5 module of the MLL1 complex. |journal=Nat. Struct. Mol. Biol. |volume=13 |issue= 8 |pages= 704-12 |year= 2006 |pmid= 16829959 |doi= 10.1038/nsmb1119 }}
*{{cite journal  |vauthors=Couture JF, Collazo E, Trievel RC |title=Molecular recognition of histone H3 by the WD40 protein WDR5. |journal=Nat. Struct. Mol. Biol. |volume=13 |issue= 8 |pages= 698–703 |year= 2006 |pmid= 16829960 |doi= 10.1038/nsmb1116 }}
*{{cite journal  | author=Couture JF, Collazo E, Trievel RC |title=Molecular recognition of histone H3 by the WD40 protein WDR5. |journal=Nat. Struct. Mol. Biol. |volume=13 |issue= 8 |pages= 698-703 |year= 2006 |pmid= 16829960 |doi= 10.1038/nsmb1116 }}
*{{cite journal   |vauthors=Dou Y, Milne TA, Ruthenburg AJ, etal |title=Regulation of MLL1 H3K4 methyltransferase activity by its core components. |journal=Nat. Struct. Mol. Biol. |volume=13 |issue= 8 |pages= 713–9 |year= 2006 |pmid= 16878130 |doi= 10.1038/nsmb1128 }}
*{{cite journal | author=Dou Y, Milne TA, Ruthenburg AJ, ''et al.'' |title=Regulation of MLL1 H3K4 methyltransferase activity by its core components. |journal=Nat. Struct. Mol. Biol. |volume=13 |issue= 8 |pages= 713-9 |year= 2006 |pmid= 16878130 |doi= 10.1038/nsmb1128 }}
*{{cite journal   |vauthors=Schuetz A, Allali-Hassani A, Martín F, etal |title=Structural basis for molecular recognition and presentation of histone H3 by WDR5. |journal=EMBO J. |volume=25 |issue= 18 |pages= 4245–52 |year= 2006 |pmid= 16946699 |doi= 10.1038/sj.emboj.7601316 | pmc=1570438 }}
*{{cite journal | author=Schuetz A, Allali-Hassani A, Martín F, ''et al.'' |title=Structural basis for molecular recognition and presentation of histone H3 by WDR5. |journal=EMBO J. |volume=25 |issue= 18 |pages= 4245-52 |year= 2006 |pmid= 16946699 |doi= 10.1038/sj.emboj.7601316 }}
*{{cite journal   |vauthors=Ewing RM, Chu P, Elisma F, etal |title=Large-scale mapping of human protein-protein interactions by mass spectrometry. |journal=Mol. Syst. Biol. |volume=3 |issue=  1|pages= 89 |year= 2007 |pmid= 17353931 |doi= 10.1038/msb4100134 | pmc=1847948 }}
*{{cite journal | author=Ewing RM, Chu P, Elisma F, ''et al.'' |title=Large-scale mapping of human protein-protein interactions by mass spectrometry. |journal=Mol. Syst. Biol. |volume=3 |issue=  |pages= 89 |year= 2007 |pmid= 17353931 |doi= 10.1038/msb4100134 }}
}}
}}
{{refend}}
{{refend}}
{{PDB Gallery|geneid=11091}}
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Revision as of 22:33, 17 September 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

WD repeat-containing protein 5 is a protein that in humans is encoded by the WDR5 gene.[1][2]

This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This protein contains 7 WD repeats. Alternatively spliced transcript variants encoding the same protein have been identified.[2]

Interactions

WDR5 has been shown to interact with Host cell factor C1[3][4] and MLL.[3] It also interacts with the long non-coding RNA HOTTIP.[5] WDR5 is a key determinant for MYC recruitment to chromatin[6]

References

  1. ↑ Gori F, Divieti P, Demay MB (Dec 2001). "Cloning and characterization of a novel WD-40 repeat protein that dramatically accelerates osteoblastic differentiation". J Biol Chem. 276 (49): 46515–22. doi:10.1074/jbc.M105757200. PMID 11551928.
  2. ↑ 2.0 2.1 "Entrez Gene: WDR5 WD repeat domain 5".
  3. ↑ 3.0 3.1 Yokoyama, Akihiko; Wang Zhong; Wysocka Joanna; Sanyal Mrinmoy; Aufiero Deborah J; Kitabayashi Issay; Herr Winship; Cleary Michael L (Jul 2004). "Leukemia proto-oncoprotein MLL forms a SET1-like histone methyltransferase complex with menin to regulate Hox gene expression". Mol. Cell. Biol. United States. 24 (13): 5639–49. doi:10.1128/MCB.24.13.5639-5649.2004. ISSN 0270-7306. PMC 480881. PMID 15199122.
  4. ↑ Wysocka, Joanna; Myers Michael P; Laherty Carol D; Eisenman Robert N; Herr Winship (Apr 2003). "Human Sin3 deacetylase and trithorax-related Set1/Ash2 histone H3-K4 methyltransferase are tethered together selectively by the cell-proliferation factor HCF-1". Genes Dev. United States. 17 (7): 896–911. doi:10.1101/gad.252103. ISSN 0890-9369. PMC 196026. PMID 12670868.
  5. ↑ Wang KC, Yang YW, Liu B, Sanyal A, Corces-Zimmerman R, Chen Y, et al. (2011). "A long noncoding RNA maintains active chromatin to coordinate homeotic gene expression". Nature. 472 (7341): 120–4. doi:10.1038/nature09819. PMID 21423168.
  6. ↑ Thomas, L. R.; Tansey, W. P. (2015). "Interaction with WDR5 Promotes Target Gene Recognition and Tumorigenesis by MYC". Molecular Cell. 58 (3): 1–13. doi:10.1016/j.molcel.2015.02.028. PMC 4427524. PMID 25818646.

Further reading



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