WSB1: Difference between revisions

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{{Infobox_gene}}
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'''WD repeat and SOCS box-containing protein 1''' is a [[protein]] that in humans is encoded by the ''WSB1'' [[gene]].<ref name="pmid10354473">{{cite journal | vauthors = Vasiliauskas D, Hancock S, Stern CD | title = SWiP-1: novel SOCS box containing WD-protein regulated by signalling centres and by Shh during development | journal = Mech Dev | volume = 82 | issue = 1–2 | pages = 79–94 |date=Aug 1999 | pmid = 10354473 | pmc = | doi =10.1016/S0925-4773(99)00014-3 }}</ref><ref name="pmid12076535">{{cite journal | vauthors = Kile BT, Schulman BA, Alexander WS, Nicola NA, Martin HM, Hilton DJ | title = The SOCS box: a tale of destruction and degradation | journal = Trends Biochem Sci | volume = 27 | issue = 5 | pages = 235–41 |date=Jun 2002 | pmid = 12076535 | pmc =  | doi =10.1016/S0968-0004(02)02085-6 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: WSB1 WD repeat and SOCS box-containing 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=26118| accessdate = }}</ref>
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{{GNF_Protein_box
| image = 
| image_source = 
| PDB =
| Name = WD repeat and SOCS box-containing 1
| HGNCid = 19221
| Symbol = WSB1
| AltSymbols =; SWIP1; WSB-1
| OMIM = 610091
| ECnumber =
| Homologene = 9218
| MGIid = 1926139
| GeneAtlas_image1 = PBB_GE_WSB1_201296_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_WSB1_210561_s_at_tn.png
| Function = {{GNF_GO|id=GO:0003674 |text = molecular_function}}
  | Component = {{GNF_GO|id=GO:0005575 |text = cellular_component}} {{GNF_GO|id=GO:0005622 |text = intracellular}}
| Process = {{GNF_GO|id=GO:0007242 |text = intracellular signaling cascade}} {{GNF_GO|id=GO:0008150 |text = biological_process}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 26118
    | Hs_Ensembl = ENSG00000109046
    | Hs_RefseqProtein = NP_056441
    | Hs_RefseqmRNA = NM_015626
    | Hs_GenLoc_db =   
    | Hs_GenLoc_chr = 17
    | Hs_GenLoc_start = 22645233
    | Hs_GenLoc_end = 22664772
    | Hs_Uniprot = Q9Y6I7
    | Mm_EntrezGene = 78889
    | Mm_Ensembl = ENSMUSG00000017677
    | Mm_RefseqmRNA = NM_001042565
    | Mm_RefseqProtein = NP_001036030
    | Mm_GenLoc_db =   
    | Mm_GenLoc_chr = 11
    | Mm_GenLoc_start = 79055577
    | Mm_GenLoc_end = 79070890
    | Mm_Uniprot = Q3TIA1
  }}
}}
'''WD repeat and SOCS box-containing 1''', also known as '''WSB1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: WSB1 WD repeat and SOCS box-containing 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=26118| accessdate = }}</ref>


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{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = This gene encodes a member of the WD-protein subfamily. This protein shares a high sequence identity to mouse and chick proteins. It contains several WD-repeats spanning most of the protein and an SOCS box in the C-terminus. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.<ref name="entrez">{{cite web | title = Entrez Gene: WSB1 WD repeat and SOCS box-containing 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=26118| accessdate = }}</ref>
| summary_text = This gene encodes a member of the WD-protein subfamily. This protein shares a high sequence identity to mouse and chick proteins. It contains several WD-repeats spanning most of the protein and an SOCS box in the C-terminus. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.<ref name="entrez">{{cite web | title = Entrez Gene: WSB1 WD repeat and SOCS box-containing 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=26118| accessdate = }}</ref>
}}
}}


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Kile BT, Schulman BA, Alexander WS, ''et al.'' |title=The SOCS box: a tale of destruction and degradation. |journal=Trends Biochem. Sci. |volume=27 |issue= 5 |pages= 235-41 |year= 2002 |pmid= 12076535 |doi=  }}
*{{cite journal  | vauthors=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides |journal=Gene |volume=138 |issue= 1–2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=10.1016/0378-1119(94)90802-8 }}
*{{cite journal  | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171-4 |year= 1994 |pmid= 8125298 |doi=  }}
*{{cite journal   |vauthors=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, etal |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library |journal=Gene |volume=200 |issue= 1–2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=10.1016/S0378-1119(97)00411-3 }}
*{{cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, ''et al.'' |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149-56 |year= 1997 |pmid= 9373149 |doi= }}
*{{cite journal   |vauthors=Hu RM, Han ZG, Song HD, etal |title=Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 17 |pages= 9543–8 |year= 2000 |pmid= 10931946 |doi= 10.1073/pnas.160270997 | pmc=16901 }}
*{{cite journal  | author=Vasiliauskas D, Hancock S, Stern CD |title=SWiP-1: novel SOCS box containing WD-protein regulated by signalling centres and by Shh during development. |journal=Mech. Dev. |volume=82 |issue= 1-2 |pages= 79-94 |year= 1999 |pmid= 10354473 |doi= }}
*{{cite journal  | vauthors=Hartley JL, Temple GF, Brasch MA |title=DNA cloning using in vitro site-specific recombination |journal=Genome Res. |volume=10 |issue= 11 |pages= 1788–95 |year= 2001 |pmid= 11076863 |doi=10.1101/gr.143000  | pmc=310948 }}
*{{cite journal | author=Hu RM, Han ZG, Song HD, ''et al.'' |title=Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 17 |pages= 9543-8 |year= 2000 |pmid= 10931946 |doi= 10.1073/pnas.160270997 }}
*{{cite journal   |vauthors=Wiemann S, Weil B, Wellenreuther R, etal |title=Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs |journal=Genome Res. |volume=11 |issue= 3 |pages= 422–35 |year= 2001 |pmid= 11230166 |doi= 10.1101/gr.GR1547R  | pmc=311072 }}
*{{cite journal  | author=Hartley JL, Temple GF, Brasch MA |title=DNA cloning using in vitro site-specific recombination. |journal=Genome Res. |volume=10 |issue= 11 |pages= 1788-95 |year= 2001 |pmid= 11076863 |doi=  }}
*{{cite journal   |vauthors=Simpson JC, Wellenreuther R, Poustka A, etal |title=Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing |journal=EMBO Rep. |volume=1 |issue= 3 |pages= 287–92 |year= 2001 |pmid= 11256614 |doi= 10.1093/embo-reports/kvd058 | pmc=1083732 }}
*{{cite journal | author=Wiemann S, Weil B, Wellenreuther R, ''et al.'' |title=Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. |journal=Genome Res. |volume=11 |issue= 3 |pages= 422-35 |year= 2001 |pmid= 11230166 |doi= 10.1101/gr.154701 }}
*{{cite journal   |vauthors=Kamura T, Burian D, Yan Q, etal |title=Muf1, a novel Elongin BC-interacting leucine-rich repeat protein that can assemble with Cul5 and Rbx1 to reconstitute a ubiquitin ligase |journal=J. Biol. Chem. |volume=276 |issue= 32 |pages= 29748–53 |year= 2001 |pmid= 11384984 |doi= 10.1074/jbc.M103093200 }}
*{{cite journal | author=Simpson JC, Wellenreuther R, Poustka A, ''et al.'' |title=Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing. |journal=EMBO Rep. |volume=1 |issue= 3 |pages= 287-92 |year= 2001 |pmid= 11256614 |doi= 10.1093/embo-reports/kvd058 }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
*{{cite journal | author=Kamura T, Burian D, Yan Q, ''et al.'' |title=Muf1, a novel Elongin BC-interacting leucine-rich repeat protein that can assemble with Cul5 and Rbx1 to reconstitute a ubiquitin ligase. |journal=J. Biol. Chem. |volume=276 |issue= 32 |pages= 29748-53 |year= 2001 |pmid= 11384984 |doi= 10.1074/jbc.M103093200 }}
*{{cite journal   |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
*{{cite journal | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal   |vauthors=Wiemann S, Arlt D, Huber W, etal |title=From ORFeome to biology: a functional genomics pipeline |journal=Genome Res. |volume=14 |issue= 10B |pages= 2136–44 |year= 2004 |pmid= 15489336 |doi= 10.1101/gr.2576704 | pmc=528930 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal   |vauthors=Dentice M, Bandyopadhyay A, Gereben B, etal |title=The Hedgehog-inducible ubiquitin ligase subunit WSB-1 modulates thyroid hormone activation and PTHrP secretion in the developing growth plate |journal=Nat. Cell Biol. |volume=7 |issue= 7 |pages= 698–705 |year= 2005 |pmid= 15965468 |doi= 10.1038/ncb1272 | pmc=1761694 }}
*{{cite journal | author=Wiemann S, Arlt D, Huber W, ''et al.'' |title=From ORFeome to biology: a functional genomics pipeline. |journal=Genome Res. |volume=14 |issue= 10B |pages= 2136-44 |year= 2004 |pmid= 15489336 |doi= 10.1101/gr.2576704 }}
*{{cite journal   |vauthors=Mehrle A, Rosenfelder H, Schupp I, etal |title=The LIFEdb database in 2006 |journal=Nucleic Acids Res. |volume=34 |issue= Database issue |pages= D415–8 |year= 2006 |pmid= 16381901 |doi= 10.1093/nar/gkj139 | pmc=1347501 }}
*{{cite journal | author=Dentice M, Bandyopadhyay A, Gereben B, ''et al.'' |title=The Hedgehog-inducible ubiquitin ligase subunit WSB-1 modulates thyroid hormone activation and PTHrP secretion in the developing growth plate. |journal=Nat. Cell Biol. |volume=7 |issue= 7 |pages= 698-705 |year= 2005 |pmid= 15965468 |doi= 10.1038/ncb1272 }}
*{{cite journal   |vauthors=Woo JS, Imm JH, Min CK, etal |title=Structural and functional insights into the B30.2/SPRY domain |journal=EMBO J. |volume=25 |issue= 6 |pages= 1353–63 |year= 2006 |pmid= 16498413 |doi= 10.1038/sj.emboj.7600994 | pmc=1422157 }}
*{{cite journal | author=Mehrle A, Rosenfelder H, Schupp I, ''et al.'' |title=The LIFEdb database in 2006. |journal=Nucleic Acids Res. |volume=34 |issue= Database issue |pages= D415-8 |year= 2006 |pmid= 16381901 |doi= 10.1093/nar/gkj139 }}
*{{cite journal   |vauthors=Chen QR, Bilke S, Wei JS, etal |title=Increased WSB1 copy number correlates with its over-expression which associates with increased survival in neuroblastoma |journal=Genes Chromosomes Cancer |volume=45 |issue= 9 |pages= 856–62 |year= 2006 |pmid= 16804916 |doi= 10.1002/gcc.20349 }}
*{{cite journal | author=Woo JS, Imm JH, Min CK, ''et al.'' |title=Structural and functional insights into the B30.2/SPRY domain. |journal=EMBO J. |volume=25 |issue= 6 |pages= 1353-63 |year= 2006 |pmid= 16498413 |doi= 10.1038/sj.emboj.7600994 }}
*{{cite journal | author=Chen QR, Bilke S, Wei JS, ''et al.'' |title=Increased WSB1 copy number correlates with its over-expression which associates with increased survival in neuroblastoma. |journal=Genes Chromosomes Cancer |volume=45 |issue= 9 |pages= 856-62 |year= 2006 |pmid= 16804916 |doi= 10.1002/gcc.20349 }}
}}
}}
{{refend}}
{{refend}}


{{protein-stub}}
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Revision as of 22:53, 17 September 2017

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

n/a

Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

WD repeat and SOCS box-containing protein 1 is a protein that in humans is encoded by the WSB1 gene.[1][2][3]

This gene encodes a member of the WD-protein subfamily. This protein shares a high sequence identity to mouse and chick proteins. It contains several WD-repeats spanning most of the protein and an SOCS box in the C-terminus. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.[3]

References

  1. Vasiliauskas D, Hancock S, Stern CD (Aug 1999). "SWiP-1: novel SOCS box containing WD-protein regulated by signalling centres and by Shh during development". Mech Dev. 82 (1–2): 79–94. doi:10.1016/S0925-4773(99)00014-3. PMID 10354473.
  2. Kile BT, Schulman BA, Alexander WS, Nicola NA, Martin HM, Hilton DJ (Jun 2002). "The SOCS box: a tale of destruction and degradation". Trends Biochem Sci. 27 (5): 235–41. doi:10.1016/S0968-0004(02)02085-6. PMID 12076535.
  3. 3.0 3.1 "Entrez Gene: WSB1 WD repeat and SOCS box-containing 1".

Further reading