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{{Infobox_gene}}
{{PBB_Controls
'''Zinc fingers and homeoboxes protein 3''' is a [[protein]] that in humans is encoded by the ''ZHX3'' [[gene]].<ref name="pmid9455477">{{cite journal |vauthors=Ishikawa K, Nagase T, Nakajima D, Seki N, Ohira M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O | title = Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro | journal = DNA Res | volume = 4 | issue = 5 | pages = 307–13 |date=Feb 1998 | pmid = 9455477 | pmc =  | doi =10.1093/dnares/4.5.307 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: ZHX3 zinc fingers and homeoboxes 3| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23051| accessdate = }}</ref>
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_ZHX3_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 2da5.
| PDB = {{PDB2|2da5}}, {{PDB2|2dn0}}
| Name = Zinc fingers and homeoboxes 3
| HGNCid = 15935
| Symbol = ZHX3
| AltSymbols =; KIAA0395; TIX1
| OMIM = 609598
| ECnumber = 
| Homologene = 9000
| MGIid = 2444772
| GeneAtlas_image1 = PBB_GE_ZHX3_212545_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_ZHX3_217367_s_at_tn.png
| Function = {{GNF_GO|id=GO:0003676 |text = nucleic acid binding}} {{GNF_GO|id=GO:0003700 |text = transcription factor activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0008270 |text = zinc ion binding}} {{GNF_GO|id=GO:0043565 |text = sequence-specific DNA binding}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}}
| Component = {{GNF_GO|id=GO:0005622 |text = intracellular}} {{GNF_GO|id=GO:0005634 |text = nucleus}}
  | Process = {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0045892 |text = negative regulation of transcription, DNA-dependent}}
  | Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 23051
    | Hs_Ensembl = ENSG00000174306
    | Hs_RefseqProtein = NP_055850
    | Hs_RefseqmRNA = NM_015035
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 20
    | Hs_GenLoc_start = 39240502
    | Hs_GenLoc_end = 39379656
    | Hs_Uniprot = Q9H4I2
    | Mm_EntrezGene = 320799
    | Mm_Ensembl = ENSMUSG00000035877
    | Mm_RefseqmRNA = NM_177263
    | Mm_RefseqProtein = NP_796237
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 2
    | Mm_GenLoc_start = 160457223
    | Mm_GenLoc_end = 160551072
    | Mm_Uniprot = Q3UPQ8
  }}
}}
'''Zinc fingers and homeoboxes 3''', also known as '''ZHX3''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: ZHX3 zinc fingers and homeoboxes 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23051| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
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{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = This gene encodes a member of the zinc fingers and homeoboxes (ZHX) gene family. The encoded protein contains two C2H2-type zinc fingers and five homeodomains and forms a dimer with itself or with zinc fingers and homeoboxes family member 1. In the nucleus, the dimerized protein interacts with the A subunit of the ubiquitous transcription factor nuclear factor-Y and may function as a transcriptional repressor.<ref name="entrez">{{cite web | title = Entrez Gene: ZHX3 zinc fingers and homeoboxes 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23051| accessdate = }}</ref>
| summary_text = This gene encodes a member of the zinc fingers and homeoboxes (ZHX) gene family. The encoded [[Protein]] contains two C2H2-type zinc fingers and five [[Homeodomain]]s and forms a [[Dimer (chemistry)|Dimer]] with itself or with [[Zinc finger]]s and homeoboxes family member 1. In the [[Cell nucleus|Nucleus]], the dimerized protein interacts with the A subunit of the ubiquitous transcription factor nuclear factor-Y and may function as a transcriptional repressor.<ref name="entrez" />
}}
}}


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Nakajima D, Okazaki N, Yamakawa H, ''et al.'' |title=Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. |journal=DNA Res. |volume=9 |issue= 3 |pages= 99-106 |year= 2003 |pmid= 12168954 |doi=  }}
*{{cite journal  | author=Nakajima D |title=Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones |journal=DNA Res. |volume=9 |issue= 3 |pages= 99–106 |year= 2003 |pmid= 12168954 |doi=10.1093/dnares/9.3.99  |name-list-format=vanc| author2=Okazaki N  | author3=Yamakawa H  | display-authors=3  | last4=Kikuno  | first4=R  | last5=Ohara  | first5=O  | last6=Nagase  | first6=T }}
*{{cite journal  | author=Liu G, Clement LC, Kanwar YS, ''et al.'' |title=ZHX proteins regulate podocyte gene expression during the development of nephrotic syndrome. |journal=J. Biol. Chem. |volume=281 |issue= 51 |pages= 39681-92 |year= 2007 |pmid= 17056598 |doi= 10.1074/jbc.M606664200 }}
*{{cite journal  | author=Liu G |title=ZHX proteins regulate podocyte gene expression during the development of nephrotic syndrome |journal=J. Biol. Chem. |volume=281 |issue= 51 |pages= 39681–92 |year= 2007 |pmid= 17056598 |doi= 10.1074/jbc.M606664200 |name-list-format=vanc| author2=Clement LC  | author3=Kanwar YS  | display-authors=3  | last4=Avila-Casado  | first4=C.  | last5=Chugh  | first5=S. S. }}
*{{cite journal  | author=Lim J, Hao T, Shaw C, ''et al.'' |title=A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration. |journal=Cell |volume=125 |issue= 4 |pages= 801-14 |year= 2006 |pmid= 16713569 |doi= 10.1016/j.cell.2006.03.032 }}
*{{cite journal  | author=Lim J |title=A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration |journal=Cell |volume=125 |issue= 4 |pages= 801–14 |year= 2006 |pmid= 16713569 |doi= 10.1016/j.cell.2006.03.032 |name-list-format=vanc| author2=Hao T  | author3=Shaw C  | display-authors=3  | last4=Patel  | first4=Akash J.  | last5=Szabó  | first5=Gábor  | last6=Rual  | first6=Jean-François  | last7=Fisk  | first7=C. Joseph  | last8=Li  | first8=Ning  | last9=Smolyar  | first9=Alex }}
*{{cite journal  | author=Beausoleil SA, Jedrychowski M, Schwartz D, ''et al.'' |title=Large-scale characterization of HeLa cell nuclear phosphoproteins. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 33 |pages= 12130-5 |year= 2004 |pmid= 15302935 |doi= 10.1073/pnas.0404720101 }}
*{{cite journal  | author=Beausoleil SA |title=Large-scale characterization of HeLa cell nuclear phosphoproteins |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 33 |pages= 12130–5 |year= 2004 |pmid= 15302935 |doi= 10.1073/pnas.0404720101 | pmc=514446  |name-list-format=vanc| author2=Jedrychowski M  | author3=Schwartz D  | display-authors=3  | last4=Elias  | first4=JE  | last5=Villén  | first5=J  | last6=Li  | first6=J  | last7=Cohn  | first7=MA  | last8=Cantley  | first8=LC  | last9=Gygi  | first9=SP }}
*{{cite journal  | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal  | author=Ota T |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |name-list-format=vanc| author2=Suzuki Y  | author3=Nishikawa T  | display-authors=3  | last4=Otsuki  | first4=Tetsuji  | last5=Sugiyama  | first5=Tomoyasu  | last6=Irie  | first6=Ryotaro  | last7=Wakamatsu  | first7=Ai  | last8=Hayashi  | first8=Koji  | last9=Sato  | first9=Hiroyuki }}
*{{cite journal  | author=Kawata H, Yamada K, Shou Z, ''et al.'' |title=The mouse zinc-fingers and homeoboxes (ZHX) family; ZHX2 forms a heterodimer with ZHX3. |journal=Gene |volume=323 |issue=  |pages= 133-40 |year= 2004 |pmid= 14659886 |doi=  }}
*{{cite journal  | author=Kawata H |title=The mouse zinc-fingers and homeoboxes (ZHX) family; ZHX2 forms a heterodimer with ZHX3 |journal=Gene |volume=323 |issue=  |pages= 133–40 |year= 2004 |pmid= 14659886 |doi=10.1016/j.gene.2003.09.013  |name-list-format=vanc| author2=Yamada K  | author3=Shou Z  | display-authors=3  | last4=Mizutani  | first4=T  | last5=Miyamoto  | first5=K }}
*{{cite journal  | author=Yamada K, Kawata H, Shou Z, ''et al.'' |title=Analysis of zinc-fingers and homeoboxes (ZHX)-1-interacting proteins: molecular cloning and characterization of a member of the ZHX family, ZHX3. |journal=Biochem. J. |volume=373 |issue= Pt 1 |pages= 167-78 |year= 2003 |pmid= 12659632 |doi= 10.1042/BJ20021866 }}
*{{cite journal  | author=Yamada K |title=Analysis of zinc-fingers and homeoboxes (ZHX)-1-interacting proteins: molecular cloning and characterization of a member of the ZHX family, ZHX3 |journal=Biochem. J. |volume=373 |issue= Pt 1 |pages= 167–78 |year= 2003 |pmid= 12659632 |doi= 10.1042/BJ20021866 | pmc=1223464  |name-list-format=vanc| author2=Kawata H  | author3=Shou Z  | display-authors=3  | last4=Hirano  | first4=Satoko  | last5=Mizutani  | first5=Tetsuya  | last6=Yazawa  | first6=Takashi  | last7=Sekiguchi  | first7=Toshio  | last8=Yoshino  | first8=Miki  | last9=Kajitani  | first9=Takashi }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | author=Strausberg RL |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241  |name-list-format=vanc| author2=Feingold EA  | author3=Grouse LH  | display-authors=3  | last4=Derge  | first4=JG  | last5=Klausner  | first5=RD  | last6=Collins  | first6=FS  | last7=Wagner  | first7=L  | last8=Shenmen  | first8=CM  | last9=Schuler  | first9=GD }}
*{{cite journal  | author=Jia L, Young MF, Powell J, ''et al.'' |title=Gene expression profile of human bone marrow stromal cells: high-throughput expressed sequence tag sequencing analysis. |journal=Genomics |volume=79 |issue= 1 |pages= 7-17 |year= 2002 |pmid= 11827452 |doi= 10.1006/geno.2001.6683 }}
*{{cite journal  | author=Jia L |title=Gene expression profile of human bone marrow stromal cells: high-throughput expressed sequence tag sequencing analysis |journal=Genomics |volume=79 |issue= 1 |pages= 7–17 |year= 2002 |pmid= 11827452 |doi= 10.1006/geno.2001.6683 |name-list-format=vanc| author2=Young MF  | author3=Powell J  | display-authors=3  | last4=Yang  | first4=Liming  | last5=Ho  | first5=Nicola C.  | last6=Hotchkiss  | first6=Robert  | last7=Robey  | first7=Pamela Gehron  | last8=Francomano  | first8=Clair A. }}
*{{cite journal  | author=Deloukas P, Matthews LH, Ashurst J, ''et al.'' |title=The DNA sequence and comparative analysis of human chromosome 20. |journal=Nature |volume=414 |issue= 6866 |pages= 865-71 |year= 2002 |pmid= 11780052 |doi= 10.1038/414865a }}
*{{cite journal  | author=Deloukas P |title=The DNA sequence and comparative analysis of human chromosome 20 |journal=Nature |volume=414 |issue= 6866 |pages= 865–71 |year= 2002 |pmid= 11780052 |doi= 10.1038/414865a  |name-list-format=vanc| author2=Matthews LH  | author3=Ashurst J  | display-authors=3  | last4=Burton  | first4=J. | last5=Gilbert  | first5=J. G. R. | last6=Jones  | first6=M. | last7=Stavrides  | first7=G.  | last8=Almeida  | first8=J. P.  | last9=Babbage  | first9=A. K. }}
*{{cite journal | author=Ishikawa K, Nagase T, Nakajima D, ''et al.'' |title=Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro. |journal=DNA Res. |volume=4 |issue= 5 |pages= 307-13 |year= 1998 |pmid= 9455477 |doi= }}
*{{cite journal  |vauthors=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery |journal=Genome Res. |volume=6 |issue= 9 |pages= 791–806 |year= 1997 |pmid= 8889548 |doi=10.1101/gr.6.9.791 }}
*{{cite journal  | author=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery. |journal=Genome Res. |volume=6 |issue= 9 |pages= 791-806 |year= 1997 |pmid= 8889548 |doi=  }}
}}
}}
{{refend}}
{{refend}}
{{PDB Gallery|geneid=23051}}
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Revision as of 01:08, 19 September 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Zinc fingers and homeoboxes protein 3 is a protein that in humans is encoded by the ZHX3 gene.[1][2]

This gene encodes a member of the zinc fingers and homeoboxes (ZHX) gene family. The encoded Protein contains two C2H2-type zinc fingers and five Homeodomains and forms a Dimer with itself or with Zinc fingers and homeoboxes family member 1. In the Nucleus, the dimerized protein interacts with the A subunit of the ubiquitous transcription factor nuclear factor-Y and may function as a transcriptional repressor.[2]

References

  1. ↑ Ishikawa K, Nagase T, Nakajima D, Seki N, Ohira M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Feb 1998). "Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 4 (5): 307–13. doi:10.1093/dnares/4.5.307. PMID 9455477.
  2. ↑ 2.0 2.1 "Entrez Gene: ZHX3 zinc fingers and homeoboxes 3".

Further reading



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