Myxoma history and symptoms: Difference between revisions
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Some symptoms of myxoma may be associated with the release of [[interleukin 6]] (IL-6) by the myxoma.<ref name="Seino-IL6">{{cite journal | author=Seino Y, Ikeda U, Shimada K. | title=Increased expression of interleukin 6 mRNA in cardiac myxomas. | journal=Br Heart J | year=1993 | volume=69 | issue=6 | pages=565-7 | id=PMID 8343326}}</ref><ref name="Jourdan-IL6">{{cite journal | author=Jourdan M, Bataille R, Seguin J, Zhang XG, Chaptal PA, Klein B | title=Constitutive production of interleukin-6 and immunologic features in cardiac myxomas.| journal=Arthritis Rheum | year=1990 | volume=33 | issue=3 | pages=398-402 | id=PMID 1690543}}</ref> High levels of IL-6 may be associated with a higher risk of embolism of the myxoma.<ref name="Wada-IL6">{{cite journal | author=Wada A, Kanda t, Hayashi R, et al. | title=Cardiac myxoma metastasized to the brain: potential role of endogenous interleukin-6. | Journal=Cardiology | year=1993 | volume=83 | issue=3 | pages=208-11 | id=PMID 8281536}}</ref> | Some symptoms of myxoma may be associated with the release of [[interleukin 6]] (IL-6) by the myxoma.<ref name="Seino-IL6">{{cite journal | author=Seino Y, Ikeda U, Shimada K. | title=Increased expression of interleukin 6 mRNA in cardiac myxomas. | journal=Br Heart J | year=1993 | volume=69 | issue=6 | pages=565-7 | id=PMID 8343326}}</ref><ref name="Jourdan-IL6">{{cite journal | author=Jourdan M, Bataille R, Seguin J, Zhang XG, Chaptal PA, Klein B | title=Constitutive production of interleukin-6 and immunologic features in cardiac myxomas.| journal=Arthritis Rheum | year=1990 | volume=33 | issue=3 | pages=398-402 | id=PMID 1690543}}</ref> High levels of IL-6 may be associated with a higher risk of embolism of the myxoma.<ref name="Wada-IL6">{{cite journal | author=Wada A, Kanda t, Hayashi R, et al. | title=Cardiac myxoma metastasized to the brain: potential role of endogenous interleukin-6. | Journal=Cardiology | year=1993 | volume=83 | issue=3 | pages=208-11 | id=PMID 8281536}}</ref> | ||
Symptoms of | Symptoms may occur at any time, but most often they accompany a change of body position. Symptoms may include: | ||
* [[ | |||
* [[ | * [[Breathing difficulty that is relieved when lying flat]] ([[platypnea]]) | ||
* [[ | * Breathing difficulty when asleep | ||
* [[Chest pain]] or tightness | |||
* [[Dizziness (patient information)|Dizziness]] | |||
* [[Fainting]] | |||
* [[Sensation of feeling your heart beat]] ([[palpitations]]) | |||
* [[Shortness of breath]] with activity\ | |||
* Lightheadedness or [[syncope]] (Loss of consciousness) | * Lightheadedness or [[syncope]] (Loss of consciousness) | ||
* [[Hemoptysis]] | * [[Hemoptysis]] | ||
* [[Sudden death]] | * [[Sudden death]] | ||
The symptoms and signs of left atrial myxomas often mimic [[mitral stenosis]]. | |||
General symptoms may also be present, such as: | |||
* Blueness of skin, especially the fingers ([[Raynaud's phenomenon]]) | |||
* [[Cough]] | |||
* Curvature of nails accompanied with soft tissue enlargement ([[clubbing]]) of the fingers | |||
* [[Fever]] | |||
* Fingers that change color upon pressure or with cold or stress | |||
* General discomfort ([[malaise]]) | |||
* Involuntary [[weight loss]] | |||
* [[Joint pain]] | |||
* Swelling - any part of the body | |||
These general symptoms may also mimic those of [[infective endocarditis]]. | |||
==References== | ==References== | ||
{{Reflist|2}} | {{Reflist|2}} | ||
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor-In-Chief: Cafer Zorkun, M.D., Ph.D. [2]
Overview
History and Symptoms
Symptoms associated with cardiac myxomas are typically due to the effect of the mass of the tumor obstructing the normal flow of blood within the chambers of the heart.
Some symptoms of myxoma may be associated with the release of interleukin 6 (IL-6) by the myxoma.[1][2] High levels of IL-6 may be associated with a higher risk of embolism of the myxoma.[3]
Symptoms may occur at any time, but most often they accompany a change of body position. Symptoms may include:
- Breathing difficulty that is relieved when lying flat (platypnea)
- Breathing difficulty when asleep
- Chest pain or tightness
- Dizziness
- Fainting
- Sensation of feeling your heart beat (palpitations)
- Shortness of breath with activity\
- Lightheadedness or syncope (Loss of consciousness)
- Hemoptysis
- Sudden death
The symptoms and signs of left atrial myxomas often mimic mitral stenosis.
General symptoms may also be present, such as:
- Blueness of skin, especially the fingers (Raynaud's phenomenon)
- Cough
- Curvature of nails accompanied with soft tissue enlargement (clubbing) of the fingers
- Fever
- Fingers that change color upon pressure or with cold or stress
- General discomfort (malaise)
- Involuntary weight loss
- Joint pain
- Swelling - any part of the body
These general symptoms may also mimic those of infective endocarditis.
References
- ↑ Seino Y, Ikeda U, Shimada K. (1993). "Increased expression of interleukin 6 mRNA in cardiac myxomas". Br Heart J. 69 (6): 565–7. PMID 8343326.
- ↑ Jourdan M, Bataille R, Seguin J, Zhang XG, Chaptal PA, Klein B (1990). "Constitutive production of interleukin-6 and immunologic features in cardiac myxomas". Arthritis Rheum. 33 (3): 398–402. PMID 1690543.
- ↑ Wada A, Kanda t, Hayashi R; et al. (1993). "Cardiac myxoma metastasized to the brain: potential role of endogenous interleukin-6". 83 (3): 208–11. PMID 8281536. Unknown parameter
|Journal=ignored (|journal=suggested) (help)