Dermatofibroma pathophysiology: Difference between revisions
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{{Dermatofibroma}} | {{Dermatofibroma}} | ||
{{CMG}} | {{CMG}} | ||
==Pathophysiology== | ==Pathophysiology== | ||
* Some physicians and researchers believe dermatofibromas form as a reaction to previous injuries such as insect bites or thorn pricks. | * Some physicians and researchers believe dermatofibromas form as a reaction to previous injuries such as insect bites or thorn pricks. | ||
* Dermatofibromas are composed of disordered [[collagen]] laid down by [[fibroblasts]]. | * Dermatofibromas are composed of disordered [[collagen]] laid down by [[fibroblasts]]. | ||
===Immunohistochemical staining=== | |||
{| class="wikitable" border="1" | |||
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! Neoplasm | |||
! [[CD34]]<ref name="Bolognia" /> | |||
! [[Stromelysin-3]]<ref>{{cite journal | pmid = 17596171 | doi=10.1111/j.1365-2133.2007.08033.x | volume=157 | issue=2 | title=Stromelysin-3 expression in the differential diagnosis of dermatofibroma and dermatofibrosarcoma protuberans: comparison with factor XIIIa and CD34 | year=2007 | month=August | author=Kim HJ, Lee JY, Kim SH, ''et al.'' | journal=Br. J. Dermatol. | pages=319–24}}</ref> | |||
! [[Factor XIIIa]]<ref>http://emedicine.medscape.com/article/1056742-overview</ref> | |||
|- | |||
| Dermatofibroma | |||
| + | |||
| + | |||
| + | |||
|- | |||
| [[Dermatofibrosarcoma protuberans]] | |||
| + | |||
| - | |||
| - | |||
|} | |||
[[Category:Needs overview]] | |||
[[Category:Needs content]] | [[Category:Needs content]] | ||
[[Category:Dermatology]] | [[Category:Dermatology]] | ||
[[Category:Disease]] | [[Category:Disease]] | ||
[[Category:Oncology]] | [[Category:Oncology]] | ||
Revision as of 14:39, 1 April 2013
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Pathophysiology
- Some physicians and researchers believe dermatofibromas form as a reaction to previous injuries such as insect bites or thorn pricks.
- Dermatofibromas are composed of disordered collagen laid down by fibroblasts.
Immunohistochemical staining
| Neoplasm | CD34[1] | Stromelysin-3[2] | Factor XIIIa[3] |
|---|---|---|---|
| Dermatofibroma | + | + | + |
| Dermatofibrosarcoma protuberans | + | - | - |
- ↑ Invalid
<ref>tag; no text was provided for refs namedBolognia - ↑ Kim HJ, Lee JY, Kim SH; et al. (2007). "Stromelysin-3 expression in the differential diagnosis of dermatofibroma and dermatofibrosarcoma protuberans: comparison with factor XIIIa and CD34". Br. J. Dermatol. 157 (2): 319–24. doi:10.1111/j.1365-2133.2007.08033.x. PMID 17596171. Unknown parameter
|month=ignored (help) - ↑ http://emedicine.medscape.com/article/1056742-overview