Lipoma causes: Difference between revisions
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==Causes== | ==Causes== | ||
The tendency to develop a lipoma is not necessarily hereditary | The tendency to develop a lipoma is not necessarily hereditary although hereditary conditions, such as [[lipomatosis|familial multiple lipomatosis]], may include lipoma development.<ref>{{cite journal |author=Leffell DJ, Braverman IM |title=Familial multiple lipomatosis. Report of a case and a review of the literature |journal=J. Am. Acad. Dermatol. |volume=15 |issue=2 Pt 1 |pages=275–9 |date=August 1986 |pmid=3745530 |doi=10.1016/S0190-9622(86)70166-7}}</ref><ref>{{cite journal |author=Toy BR |title=Familial multiple lipomatosis |journal=Dermatol. Online J. |volume=9 |issue=4 |pages=9 |date=October 2003 |pmid=14594582 |url=http://dermatology.cdlib.org/94/NYU/Jan2002/2.html}}</ref> Genetic studies in mice have shown a correlation between the ''HMG I-C'' gene (previously identified as a gene related to obesity) and lipoma development. These studies support prior epidemiologic data in humans showing a correlation between ''HMG I-C'' and mesenchymal tumors.<ref>{{cite journal | author=Arlotta P, Tai AK, Manfioletti G, Clifford C, Jay G, Ono SJ. |title= Transgenic mice expressing a truncated form of the high mobility group I-C protein develop adiposity and an abnormally high prevalence of lipomas |journal=J Biol Chem.|volume=275|issue=19 |pages=14394–400|date=May 2000 |pmid=10747931 | doi=10.1074/jbc.M000564200}}</ref> | ||
Cases have been reported where minor injuries are alleged to have triggered the growth of a lipoma, called "post-traumatic lipomas."<ref>{{cite journal |author=Signorini M, Campiglio GL |title=Posttraumatic lipomas: where do they really come from? |journal=Plast. Reconstr. Surg. |volume=101 |issue=3 |pages=699–705 |date=March 1998 |pmid=9500386 |doi=10.1097/00006534-199803000-00017}}</ref> However, the link between trauma and the development of lipomas is controversial.<ref>{{cite journal |author=Aust MC, Spies M, Kall S, Jokuszies A, Gohritz A, Vogt P |title=Posttraumatic lipoma: fact or fiction? |journal=Skinmed |volume=6 |issue=6 |pages=266–70 |year=2007 |pmid=17975353 |url=http://www.lejacq.com/articleDetail.cfm?pid=SKINmed_6;6:266 |doi=10.1111/j.1540-9740.2007.06361.x}}</ref> | |||
==References== | ==References== | ||
Revision as of 18:13, 19 August 2015
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Causes
The tendency to develop a lipoma is not necessarily hereditary although hereditary conditions, such as familial multiple lipomatosis, may include lipoma development.[1][2] Genetic studies in mice have shown a correlation between the HMG I-C gene (previously identified as a gene related to obesity) and lipoma development. These studies support prior epidemiologic data in humans showing a correlation between HMG I-C and mesenchymal tumors.[3]
Cases have been reported where minor injuries are alleged to have triggered the growth of a lipoma, called "post-traumatic lipomas."[4] However, the link between trauma and the development of lipomas is controversial.[5]
References
- ↑ Leffell DJ, Braverman IM (August 1986). "Familial multiple lipomatosis. Report of a case and a review of the literature". J. Am. Acad. Dermatol. 15 (2 Pt 1): 275–9. doi:10.1016/S0190-9622(86)70166-7. PMID 3745530.
- ↑ Toy BR (October 2003). "Familial multiple lipomatosis". Dermatol. Online J. 9 (4): 9. PMID 14594582.
- ↑ Arlotta P, Tai AK, Manfioletti G, Clifford C, Jay G, Ono SJ. (May 2000). "Transgenic mice expressing a truncated form of the high mobility group I-C protein develop adiposity and an abnormally high prevalence of lipomas". J Biol Chem. 275 (19): 14394–400. doi:10.1074/jbc.M000564200. PMID 10747931.
- ↑ Signorini M, Campiglio GL (March 1998). "Posttraumatic lipomas: where do they really come from?". Plast. Reconstr. Surg. 101 (3): 699–705. doi:10.1097/00006534-199803000-00017. PMID 9500386.
- ↑ Aust MC, Spies M, Kall S, Jokuszies A, Gohritz A, Vogt P (2007). "Posttraumatic lipoma: fact or fiction?". Skinmed. 6 (6): 266–70. doi:10.1111/j.1540-9740.2007.06361.x. PMID 17975353.