Cervical intraepithelial neoplasia: Difference between revisions
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{{CMG}} {{AE}} {{MV}} | |||
{{SK}} CIN; cervical interstitial neoplasia; cervical dysplasia; cervical interstitial neoplasia | |||
==Overview== | |||
==Historical Perspective== | |||
*Cervical intraepithelial neoplasia was first discovered by Dr. Georgios Nikolaou Papanikolaou, a Greek pathologist, in 1927.<ref name="wiki>Georgios Nikolaou Papanikolaou Wikipedia. https://en.wikipedia.org/wiki/Georgios_Papanikolaou Accessed on March 29, 2016</ref> | |||
*In 1928, the first screening was developed by Aurel Babeș, a Romanian pathologist to diagnose cervical intraepithelial neoplasia.<ref name="wiki> Aurel Babes. Wikipedia https://en.wikipedia.org/wiki/Aurel_Babe%C8%99. Accessed on March 29, 2016</ref> | |||
*In 1980, human papillomavirus (HPV) was first identified in the pathogenesis of cervical intraepithelial neoplasia.<ref name="pmid23399794">{{cite journal |vauthors=Herfs M, Crum CP |title=Laboratory management of cervical intraepithelial neoplasia: proposing a new paradigm |journal=Adv Anat Pathol |volume=20 |issue=2 |pages=86–94 |year=2013 |pmid=23399794 |doi=10.1097/PAP.0b013e3182862aab |url=}}</ref> | |||
==Classification== | |||
== | *Cervical intraepithelial neoplasia has 4 cytological classifications: Bethesda system, Papanicolaou classification, CIN nomenclature, and dysplasia nomenclature. | ||
*Cervical intraepithelial neoplasia may be classified according to Papanicolau into 3 subtypes: | |||
:* '''CIN1''' (Grade I) | |||
:* '''CIN2''' (Grade II) | |||
:* '''CIN3''' (Grade III) | |||
*Cervical intraepithelial neoplasia may be classified according to Bethesda system into 3 subtypes: | |||
:*Low grade squamous intraepithelial lesion (LGSIL) | |||
:*High grade squamous intraepithelial lesions (HSIL) | |||
:*Carcinoma in situ | |||
*Other variants of cervical intraepithelial neoplasia include [disease subtype 1], [disease subtype 2], and [disease subtype 3]. | |||
== | |||
==Pathophysiology== | |||
*The pathogenesis of cervical intraepithelial neoplasia is characterized by [feature1], [feature2], and [feature3]. | |||
*The [gene name] gene/Mutation in [gene name] has been associated with the development of cervical intraepithelial neoplasia, involving the [molecular pathway] pathway. | |||
== | *On gross pathology, [feature1], [feature2], and [feature3] are characteristic findings of cervical intraepithelial neoplasia. | ||
*On microscopic histopathological analysis, [feature1], [feature2], and [feature3] are characteristic findings of cervical intraepithelial neoplasia. | |||
== | |||
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Revision as of 19:47, 29 March 2016
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Maria Fernanda Villarreal, M.D. [2]
Synonyms and keywords: CIN; cervical interstitial neoplasia; cervical dysplasia; cervical interstitial neoplasia
Overview
Historical Perspective
- Cervical intraepithelial neoplasia was first discovered by Dr. Georgios Nikolaou Papanikolaou, a Greek pathologist, in 1927.[1]
- In 1928, the first screening was developed by Aurel Babeș, a Romanian pathologist to diagnose cervical intraepithelial neoplasia.[1]
- In 1980, human papillomavirus (HPV) was first identified in the pathogenesis of cervical intraepithelial neoplasia.[2]
Classification
- Cervical intraepithelial neoplasia has 4 cytological classifications: Bethesda system, Papanicolaou classification, CIN nomenclature, and dysplasia nomenclature.
- Cervical intraepithelial neoplasia may be classified according to Papanicolau into 3 subtypes:
- CIN1 (Grade I)
- CIN2 (Grade II)
- CIN3 (Grade III)
- Cervical intraepithelial neoplasia may be classified according to Bethesda system into 3 subtypes:
- Low grade squamous intraepithelial lesion (LGSIL)
- High grade squamous intraepithelial lesions (HSIL)
- Carcinoma in situ
- Other variants of cervical intraepithelial neoplasia include [disease subtype 1], [disease subtype 2], and [disease subtype 3].
Pathophysiology
- The pathogenesis of cervical intraepithelial neoplasia is characterized by [feature1], [feature2], and [feature3].
- The [gene name] gene/Mutation in [gene name] has been associated with the development of cervical intraepithelial neoplasia, involving the [molecular pathway] pathway.
- On gross pathology, [feature1], [feature2], and [feature3] are characteristic findings of cervical intraepithelial neoplasia.
- On microscopic histopathological analysis, [feature1], [feature2], and [feature3] are characteristic findings of cervical intraepithelial neoplasia.
- ↑ 1.0 1.1 Georgios Nikolaou Papanikolaou Wikipedia. https://en.wikipedia.org/wiki/Georgios_Papanikolaou Accessed on March 29, 2016
- ↑ Herfs M, Crum CP (2013). "Laboratory management of cervical intraepithelial neoplasia: proposing a new paradigm". Adv Anat Pathol. 20 (2): 86–94. doi:10.1097/PAP.0b013e3182862aab. PMID 23399794.