Chronic lymphocytic leukemia epidemiology and demographics: Difference between revisions
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==Overview== | ==Overview== | ||
In 2011, the age-adjusted [[incidence]] of chronic lymphocytic leukemia (CLL) was 4.82 per 100,000 persons in the United States.<ref name="SEER">Howlader N, Noone AM, Krapcho M, Garshell J, Miller D, Altekruse SF, Kosary CL, Yu M, Ruhl J, Tatalovich Z,Mariotto A, Lewis DR, Chen HS, Feuer EJ, Cronin KA (eds). SEER Cancer Statistics Review, 1975-2011, National Cancer Institute. Bethesda, MD, http://seer.cancer.gov/csr/1975_2011/, based on November 2013 SEER data submission, posted to the SEER web site, April 2014.</ref> [[CLL]] is a disease of the elderly and is rarely encountered in individuals under the age of 40. Most (>75%) people newly diagnosed with CLL are over age 50. Thereafter the disease incidence increases with age. | |||
==Epidemiology and Demographics== | |||
===Prevalence=== | |||
The [[prevalence]] of CLL ranges from a low of 10 per 100,000 patients, to a high of 50 per 100,000 patients with an average prevalence of 30 per 100,000 patients. | |||
===Incidence=== | ===Incidence=== | ||
The [[incidence]] of CLL in developed countries is 4 per 100,000. It increases to more than 30 per 100,000 at age 80 yrs. | * The [[incidence]] of CLL in developed countries is 4 per 100,000. It increases to more than 30 per 100,000 at age 80 yrs. | ||
* In 2011, the age-adjusted [[incidence]] of CLL was 4.82 per 100,000 persons in the United States.<ref name="SEER">Howlader N, Noone AM, Krapcho M, Garshell J, Miller D, Altekruse SF, Kosary CL, Yu M, Ruhl J, Tatalovich Z,Mariotto A, Lewis DR, Chen HS, Feuer EJ, Cronin KA (eds). SEER Cancer Statistics Review, 1975-2011, National Cancer Institute. Bethesda, MD, http://seer.cancer.gov/csr/1975_2011/, based on November 2013 SEER data submission, posted to the SEER web site, April 2014.</ref> | |||
===Age=== | ===Age=== | ||
[[CLL]] is a disease of the elderly and is rarely encountered in individuals under the age of 40. Most (>75%) people newly diagnosed with CLL are over age 50. Thereafter the disease incidence increases with age. Of note, subclinical "disease" can be identified in up to 7-8% of individuals over the age of 70. That is, small clones of B cells with the characteristic CLL phenotype can be identified in many healthy elderly persons. The clinical significance of these cells is unknown. | * [[CLL]] is a disease of the elderly and is rarely encountered in individuals under the age of 40. Most (>75%) people newly diagnosed with CLL are over age 50. Thereafter the disease incidence increases with age. Of note, subclinical "disease" can be identified in up to 7-8% of individuals over the age of 70. That is, small clones of B cells with the characteristic CLL phenotype can be identified in many healthy elderly persons. The clinical significance of these cells is unknown. | ||
* While the overall age-adjusted [[incidence]] of CLL in the United States between 2007 and 2011 is 4.4 per 100,000, the age-adjusted [[incidence]] of CLL by age category is:<ref name="SEER">Howlader N, Noone AM, Krapcho M, Garshell J, Miller D, Altekruse SF, Kosary CL, Yu M, Ruhl J, Tatalovich Z,Mariotto A, Lewis DR, Chen HS, Feuer EJ, Cronin KA (eds). SEER Cancer Statistics Review, 1975-2011, National Cancer Institute. Bethesda, MD, http://seer.cancer.gov/csr/1975_2011/, based on November 2013 SEER data submission, posted to the SEER web site, April 2014.</ref> | |||
** Under 65 years: 1.4 per 100,000 | |||
** 65 and over: 25.2 per 100,000 | |||
===Gender=== | ===Gender=== | ||
[[CLL]] is more common in men. Two thirds of the patients are men. | * [[CLL]] is more common in men. Two thirds of the patients are men. | ||
* In the United States, the age-adjusted [[incidence]] of CLL by gender on 2011 is:<ref name="SEER">Howlader N, Noone AM, Krapcho M, Garshell J, Miller D, Altekruse SF, Kosary CL, Yu M, Ruhl J, Tatalovich Z,Mariotto A, Lewis DR, Chen HS, Feuer EJ, Cronin KA (eds). SEER Cancer Statistics Review, 1975-2011, National Cancer Institute. Bethesda, MD, http://seer.cancer.gov/csr/1975_2011/, based on November 2013 SEER data submission, posted to the SEER web site, April 2014.</ref> | |||
** In males: 6.44 per 100,000 persons | |||
** In females: 3.51 per 100,000 persons | |||
===Race=== | ===Race=== | ||
Revision as of 18:02, 12 June 2014
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Raviteja Guddeti, M.B.B.S. [2]
Overview
In 2011, the age-adjusted incidence of chronic lymphocytic leukemia (CLL) was 4.82 per 100,000 persons in the United States.[1] CLL is a disease of the elderly and is rarely encountered in individuals under the age of 40. Most (>75%) people newly diagnosed with CLL are over age 50. Thereafter the disease incidence increases with age.
Epidemiology and Demographics
Prevalence
The prevalence of CLL ranges from a low of 10 per 100,000 patients, to a high of 50 per 100,000 patients with an average prevalence of 30 per 100,000 patients.
Incidence
- The incidence of CLL in developed countries is 4 per 100,000. It increases to more than 30 per 100,000 at age 80 yrs.
Age
- CLL is a disease of the elderly and is rarely encountered in individuals under the age of 40. Most (>75%) people newly diagnosed with CLL are over age 50. Thereafter the disease incidence increases with age. Of note, subclinical "disease" can be identified in up to 7-8% of individuals over the age of 70. That is, small clones of B cells with the characteristic CLL phenotype can be identified in many healthy elderly persons. The clinical significance of these cells is unknown.
- While the overall age-adjusted incidence of CLL in the United States between 2007 and 2011 is 4.4 per 100,000, the age-adjusted incidence of CLL by age category is:[1]
- Under 65 years: 1.4 per 100,000
- 65 and over: 25.2 per 100,000
Gender
- CLL is more common in men. Two thirds of the patients are men.
- In the United States, the age-adjusted incidence of CLL by gender on 2011 is:[1]
- In males: 6.44 per 100,000 persons
- In females: 3.51 per 100,000 persons
Race
CLL is common in the white race compared to the black race.
References
- ↑ 1.0 1.1 1.2 1.3 Howlader N, Noone AM, Krapcho M, Garshell J, Miller D, Altekruse SF, Kosary CL, Yu M, Ruhl J, Tatalovich Z,Mariotto A, Lewis DR, Chen HS, Feuer EJ, Cronin KA (eds). SEER Cancer Statistics Review, 1975-2011, National Cancer Institute. Bethesda, MD, http://seer.cancer.gov/csr/1975_2011/, based on November 2013 SEER data submission, posted to the SEER web site, April 2014.