Mast cell tumor: Difference between revisions
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==Overview== | ==Overview== | ||
A mast cell originates from the [[bone marrow]] and is normally found throughout the [[connective tissue]] of the body. It is a normal component of the [[immune system]] and as it releases [[histamine]] it is associated with [[allergy|allergic reaction]]s. Mast cells also respond to tissue [[physical trauma|trauma]]. Mast cell [[granule]]s contain histamine, [[heparin]], [[platelet-activating factor]], and other substances. Disseminated [[mastocytosis]] is rarely seen in young dogs and cats, while mast cell tumors are a common [[malignant]] tumor of the skin in older dogs and cats. Up to 20 to 25 percent of skin tumors in dogs are mast cell tumors,<ref name=saph>{{cite journal |author=Brière C |title=Use of a reverse saphenous skin flap for the excision of a grade II mast cell tumor on the hind limb of a dog |journal=Can Vet J |volume=43 |issue=8 |pages=620-2 |year=2002 |id=PMID 12170840}}</ref> with a similar number in cats.<ref name=pathol>{{cite journal |author=Johnson T, Schulman F, Lipscomb T, Yantis L |title=Histopathology and biologic behavior of pleomorphic cutaneous mast cell tumors in fifteen cats |journal=Vet Pathol |volume=39 |issue=4 |pages=452-7 |year=2002 |id=PMID 12126148}}</ref> | A mast cell originates from the [[bone marrow]] and is normally found throughout the [[connective tissue]] of the body. It is a normal component of the [[immune system]] and as it releases [[histamine]] it is associated with [[allergy|allergic reaction]]s. Mast cells also respond to tissue [[physical trauma|trauma]]. Mast cell [[granule]]s contain histamine, [[heparin]], [[platelet-activating factor]], and other substances. Disseminated [[mastocytosis]] is rarely seen in young dogs and cats, while mast cell tumors are a common [[malignant]] tumor of the skin in older dogs and cats. Up to 20 to 25 percent of skin tumors in dogs are mast cell tumors,<ref name=saph>{{cite journal |author=Brière C |title=Use of a reverse saphenous skin flap for the excision of a grade II mast cell tumor on the hind limb of a dog |journal=Can Vet J |volume=43 |issue=8 |pages=620-2 |year=2002 |id=PMID 12170840}}</ref> with a similar number in cats.<ref name=pathol>{{cite journal |author=Johnson T, Schulman F, Lipscomb T, Yantis L |title=Histopathology and biologic behavior of pleomorphic cutaneous mast cell tumors in fifteen cats |journal=Vet Pathol |volume=39 |issue=4 |pages=452-7 |year=2002 |id=PMID 12126148}}</ref> | ||
Revision as of 16:31, 12 September 2012
| Mast cell tumor | |
| ICD-10 | C96.2, D47.0 |
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| ICD-9 | 238.5 |
| DiseasesDB | 34450 |
| MeSH | D034801 |
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Overview
A mast cell originates from the bone marrow and is normally found throughout the connective tissue of the body. It is a normal component of the immune system and as it releases histamine it is associated with allergic reactions. Mast cells also respond to tissue trauma. Mast cell granules contain histamine, heparin, platelet-activating factor, and other substances. Disseminated mastocytosis is rarely seen in young dogs and cats, while mast cell tumors are a common malignant tumor of the skin in older dogs and cats. Up to 20 to 25 percent of skin tumors in dogs are mast cell tumors,[1] with a similar number in cats.[2]
References
- ↑ Brière C (2002). "Use of a reverse saphenous skin flap for the excision of a grade II mast cell tumor on the hind limb of a dog". Can Vet J. 43 (8): 620–2. PMID 12170840.
- ↑ Johnson T, Schulman F, Lipscomb T, Yantis L (2002). "Histopathology and biologic behavior of pleomorphic cutaneous mast cell tumors in fifteen cats". Vet Pathol. 39 (4): 452–7. PMID 12126148.