Langerhans cell histiocytosis laboratory tests: Difference between revisions

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Revision as of 19:39, 13 September 2012

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

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Diagnosis of LCH is confirmed histologically by tissue biopsy.
Haemotoxilin-eosin stain of biopsy slide will show features of Langerhans cell e.g. distinct cell margin, pink granular cytoplasm. Presence of Birbeck granules on electron microscopy and immuno-cytochemical features e. g. CD1 positivity are more specific.
Initially routine blood tests e.g. full blood count, liver function test, U&Es, bone profile are done to determine disease extent and rule out other causes.
Assessment of endocrine function and bone marrow biopsy are also performed when indicated.

@@ Line 7: / Line 7: @@
 ==Overview==
 ==Laboratory Findings==
-Diagnosis of LCH is confirmed [[histologically]] by [[tissue]] [[biopsy]].
+*Diagnosis of LCH is confirmed [[histologically]] by [[tissue]] [[biopsy]].
-<br />Haemotoxilin-eosin stain of biopsy slide will show features of Langerhans cell e.g. distinct cell margin, pink granular [[cytoplasm]]. Presence of [[Birbeck granules]] on [[electron microscopy]] and [[immuno-cytochemistry|immuno-cytochemical]] features e. g. [[CD1]] positivity are more specific.
+*Haemotoxilin-eosin stain of biopsy slide will show features of Langerhans cell e.g. distinct cell margin, pink granular [[cytoplasm]]. Presence of [[Birbeck granules]] on [[electron microscopy]] and [[immuno-cytochemistry|immuno-cytochemical]] features e. g. [[CD1]] positivity are more specific.
-<br />Initially routine blood tests e.g. full blood count, liver function test, U&Es, bone profile are done to determine disease extent and rule out other causes.
+*Initially routine blood tests e.g. full blood count, liver function test, U&Es, bone profile are done to determine disease extent and rule out other causes.
+*Assessment of [[endocrine]] function and bone marrow biopsy are also performed when indicated.
-Assessment of [[endocrine]] function and bone marrow biopsy are also performed when indicated.
 ==References==