Multiple myeloma overview: Difference between revisions
No edit summary |
|||
| Line 5: | Line 5: | ||
'''Multiple myeloma''' is a type of [[cancer]] of [[plasma cell]]s which are [[immune system]] cells in bone marrow that produce [[antibody|antibodies]]. Its [[prognosis]], despite therapy, is generally poor, and treatment may involve [[chemotherapy]] and [[stem cell transplant]]. It is part of the broad group of diseases called [[Hematological malignancy|hematological malignancies]]. | '''Multiple myeloma''' is a type of [[cancer]] of [[plasma cell]]s which are [[immune system]] cells in bone marrow that produce [[antibody|antibodies]]. Its [[prognosis]], despite therapy, is generally poor, and treatment may involve [[chemotherapy]] and [[stem cell transplant]]. It is part of the broad group of diseases called [[Hematological malignancy|hematological malignancies]]. | ||
===Pathophysiology=== | |||
It is a disorder affecting post germinal center B lymphocytes. A chromosomal translocation between the immunoglobulin heavy chain gene and one of many oncogenes leads to dysregulated multiplication of plasma cells. This leads to both localised damage, resulting in punched out bony lesions as well as various organ damage and other symptoms. | |||
==References== | ==References== | ||
{{Reflist|2}} | {{Reflist|2}} | ||
Revision as of 02:09, 17 February 2014
|
Multiple myeloma Microchapters |
|
Diagnosis |
|---|
|
Treatment |
|
Case Studies |
|
Multiple myeloma overview On the Web |
|
American Roentgen Ray Society Images of Multiple myeloma overview |
|
Risk calculators and risk factors for Multiple myeloma overview |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Multiple myeloma is a type of cancer of plasma cells which are immune system cells in bone marrow that produce antibodies. Its prognosis, despite therapy, is generally poor, and treatment may involve chemotherapy and stem cell transplant. It is part of the broad group of diseases called hematological malignancies.
Pathophysiology
It is a disorder affecting post germinal center B lymphocytes. A chromosomal translocation between the immunoglobulin heavy chain gene and one of many oncogenes leads to dysregulated multiplication of plasma cells. This leads to both localised damage, resulting in punched out bony lesions as well as various organ damage and other symptoms.