Thyroid adenoma: Difference between revisions
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== Overview == | == Overview == | ||
A '''thyroid adenoma''', or '''solitary thyroid nodule''' is a [[benign tumor]] of the [[thyroid]] gland. A thyroid adenoma is distinguished from a [[goitre|multinodular goiter]] of the thyroid in that an adenoma is typically solitary, and is a [[neoplasm]] resulting from a genetic [[mutation]] (or other genetic abnormality) in a single precursor cell.<ref name="robbins">{{cite book |author=Ramzi Cotran, Vinay Kumar, Tucker Collins |title=Robbins Pathologic Basis of Disease, 6th Edition |year=1999 |publisher=W.B. Saunders |isbn=072167335X |pages=}}</ref> In contrast, a multinodular goiter is usually thought to result from a [[hyperplasia|hyperplastic]] response of the entire thyroid gland to a stimulus, such as [[iodine deficiency]]. | A '''thyroid adenoma''', or '''solitary thyroid nodule''' is a [[benign tumor]] of the [[thyroid]] gland. | ||
==Pathophysiology== | |||
A thyroid adenoma may be clinically silent, or it may be a "functional" tumor, producing excessive [[thyroid hormone]]. In this case, it may result in symptomatic [[hyperthyroidism]], and may be referred to as a ''toxic'' thyroid adenoma. Careful [[pathology|pathological]] examination may be necessary to distinguish a thyroid adenoma from a minimally invasive [[thyroid cancer|follicular thyroid carcinoma]].<ref name="robbins"/> | |||
==Differentiating Thyroid adenoma from other Diseases== | |||
A thyroid adenoma is distinguished from a [[goitre|multinodular goiter]] of the thyroid in that an adenoma is typically solitary, and is a [[neoplasm]] resulting from a genetic [[mutation]] (or other genetic abnormality) in a single precursor cell.<ref name="robbins">{{cite book |author=Ramzi Cotran, Vinay Kumar, Tucker Collins |title=Robbins Pathologic Basis of Disease, 6th Edition |year=1999 |publisher=W.B. Saunders |isbn=072167335X |pages=}}</ref> In contrast, a multinodular goiter is usually thought to result from a [[hyperplasia|hyperplastic]] response of the entire thyroid gland to a stimulus, such as [[iodine deficiency]]. | |||
==References== | ==References== | ||
Revision as of 14:10, 18 September 2012
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
A thyroid adenoma, or solitary thyroid nodule is a benign tumor of the thyroid gland.
Pathophysiology
A thyroid adenoma may be clinically silent, or it may be a "functional" tumor, producing excessive thyroid hormone. In this case, it may result in symptomatic hyperthyroidism, and may be referred to as a toxic thyroid adenoma. Careful pathological examination may be necessary to distinguish a thyroid adenoma from a minimally invasive follicular thyroid carcinoma.[1]
Differentiating Thyroid adenoma from other Diseases
A thyroid adenoma is distinguished from a multinodular goiter of the thyroid in that an adenoma is typically solitary, and is a neoplasm resulting from a genetic mutation (or other genetic abnormality) in a single precursor cell.[1] In contrast, a multinodular goiter is usually thought to result from a hyperplastic response of the entire thyroid gland to a stimulus, such as iodine deficiency.
References
- ↑ 1.0 1.1 Ramzi Cotran, Vinay Kumar, Tucker Collins (1999). Robbins Pathologic Basis of Disease, 6th Edition. W.B. Saunders. ISBN 072167335X.
Acknowledgements
The content on this page was first contributed by: C. Michael Gibson, M.S., M.D. Template:WH Template:WikiDoc Sources