T-cell large granular lymphocyte leukemia laboratory findings: Difference between revisions
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==Laboratory Findings== | ==Laboratory Findings== | ||
* Complete blood count and differential count - [[neutropenia]], [[anemia]], [[lymphocytosis]] (in the range of 2-20x10<sup>9</sup>/L) | * Complete blood count and differential count - [[neutropenia]], [[anemia]], [[lymphocytosis]] (in the range of 2-20x10<sup>9</sup>/L) | ||
* [[Immunoglobulin]] derangements including [[hypergammaglobulinemia]], [[autoantibodies]], and [[circulating immune complexes]] are commonly seen.<ref | * [[Immunoglobulin]] derangements including [[hypergammaglobulinemia]], [[autoantibodies]], and [[circulating immune complexes]] are commonly seen.<ref>{{cite journal |author=Oshimi K, Yamada O, Kaneko T, ''et al.'' |title=Laboratory findings and clinical courses of 33 patients with granular lymphocyte-proliferative disorders |journal=Leukemia |volume=7 |issue=6 |pages=782–8 |year=1993 |month=June |pmid=8388971 |doi= |url=}}</ref><ref name="lou1">{{cite journal |author=Loughran TP, Starkebaum G, Aprile JA |title=Rearrangement and expression of T-cell receptor genes in large granular lymphocyte leukemia |journal=Blood |volume=71 |issue=3 |pages=822–4 |year=1988 |month=March |pmid=3345349 |doi= |url=http://www.bloodjournal.org/cgi/pmidlookup?view=long&pmid=3345349}}</ref><ref name="lou2">{{cite journal |author=Loughran TP, Kadin ME, Starkebaum G, ''et al.'' |title=Leukemia of large granular lymphocytes: association with clonal chromosomal abnormalities and autoimmune neutropenia, thrombocytopenia, and hemolytic anemia |journal=Ann. Intern. Med. |volume=102 |issue=2 |pages=169–75 |year=1985 |month=February |pmid=3966754 |doi= |url=}}</ref> | ||
===Immunophenotype=== | ===Immunophenotype=== |
Revision as of 16:44, 18 September 2012
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
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Overview
Laboratory Findings
- Complete blood count and differential count - neutropenia, anemia, lymphocytosis (in the range of 2-20x109/L)
- Immunoglobulin derangements including hypergammaglobulinemia, autoantibodies, and circulating immune complexes are commonly seen.[1][2][3]
Immunophenotype
The neoplastic cells of this disease display a mature T-cell immunophenotype, with the majority of cases showing a CD4-/CD8+ T-cell subset immunophenotype versus other permutations of those markers.[4][5] Variable expression of CD11b, CD56, and CD57[6] are observed. Immunohistochemisty for perforin, TIA-1, and granzyme B are usually positive.[7]
Type | Immunophenotype |
---|---|
Common type (80% of cases) | CD3+, TCRαβ+, CD4-, CD8+ |
Rare variants | CD3+, TCRαβ+, CD4+, CD8- |
CD3+, TCRαβ+, CD4+, CD8+ | |
CD3+, TCRγδ+, CD4 and CD8 variable |
References
- ↑ Oshimi K, Yamada O, Kaneko T; et al. (1993). "Laboratory findings and clinical courses of 33 patients with granular lymphocyte-proliferative disorders". Leukemia. 7 (6): 782–8. PMID 8388971. Unknown parameter
|month=
ignored (help) - ↑ Loughran TP, Starkebaum G, Aprile JA (1988). "Rearrangement and expression of T-cell receptor genes in large granular lymphocyte leukemia". Blood. 71 (3): 822–4. PMID 3345349. Unknown parameter
|month=
ignored (help) - ↑ Loughran TP, Kadin ME, Starkebaum G; et al. (1985). "Leukemia of large granular lymphocytes: association with clonal chromosomal abnormalities and autoimmune neutropenia, thrombocytopenia, and hemolytic anemia". Ann. Intern. Med. 102 (2): 169–75. PMID 3966754. Unknown parameter
|month=
ignored (help) - ↑
- ↑
- ↑
- ↑