Insulin resistance historical perspective: Difference between revisions
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==Overview== | ==Overview== | ||
In the 1950's, research scientists Solomon Berson and Rosalyn Yalow developed a technique to measure circulating levels of hormones and other substances in the blood, called radioimmunoassay. Using this technique lead Berson and Yalow to discover that individuals with type 2 diabetes exhibited higher than average levels of circulating insulin than individuals with normal glucose tolerance. | |||
==Historical Perspective== | ==Historical Perspective== | ||
The concept that insulin resistance may be the underlying cause of [[diabetes mellitus]] type 2 was first advanced by Sir [[Harold Percival Himsworth]] of the University College Hospital Medical Center in London in 1936.<ref name=Himsworth_1936>{{cite journal | author = Himsworth HP | title = Diabetes mellitus: its differentiation into insulin-sensitive and insulin-insensitive types | journal = Lancet | year = 1936 | volume = 1 | pages = 127–130 | url= }}</ref> | The concept that insulin resistance may be the underlying cause of [[diabetes mellitus]] type 2 was first advanced by Sir [[Harold Percival Himsworth]] of the University College Hospital Medical Center in London in 1936.<ref name=Himsworth_1936>{{cite journal | author = Himsworth HP | title = Diabetes mellitus: its differentiation into insulin-sensitive and insulin-insensitive types | journal = Lancet | year = 1936 | volume = 1 | pages = 127–130 | url= }}</ref> | ||
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
In the 1950's, research scientists Solomon Berson and Rosalyn Yalow developed a technique to measure circulating levels of hormones and other substances in the blood, called radioimmunoassay. Using this technique lead Berson and Yalow to discover that individuals with type 2 diabetes exhibited higher than average levels of circulating insulin than individuals with normal glucose tolerance.
Historical Perspective
The concept that insulin resistance may be the underlying cause of diabetes mellitus type 2 was first advanced by Sir Harold Percival Himsworth of the University College Hospital Medical Center in London in 1936.[1]
References
- ↑ Himsworth HP (1936). "Diabetes mellitus: its differentiation into insulin-sensitive and insulin-insensitive types". Lancet. 1: 127&ndash, 130.