Glucocorticoid resistance: Difference between revisions
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{{SK | {{SK}} Cortisol resistance; glucocorticoid insensitivity; steroid hormone resistance; glucocorticoid receptor, steroid hormone insensitivity; overexpression of human glucocorticoid receptor beta, generalized partial end-organ insensitivity to physiologic glucocorticoid concentrations; elevations in circulating cortisol; mineralocorticoid excess; androgen excess | ||
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== Overview == | == Overview == | ||
Patients can be both resistant and hypersensitive to glucocorticoids. | Patients can be both [[resistant]] and [[hypersensitive]] to [[glucocorticoids]]. | ||
In glucocorticoid resistance, the target tissue is unable to respond to glucocorticoids. The lack of responsiveness can be | In glucocorticoid resistance, the [[target tissue]] is unable to respond to glucocorticoids. The lack of responsiveness can be | ||
#Generalized or tissue-specific | #Generalized or tissue-specific | ||
#Transient or permanent | #Transient or permanent | ||
Latest revision as of 20:34, 19 September 2012
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Synonyms and keywords: Cortisol resistance; glucocorticoid insensitivity; steroid hormone resistance; glucocorticoid receptor, steroid hormone insensitivity; overexpression of human glucocorticoid receptor beta, generalized partial end-organ insensitivity to physiologic glucocorticoid concentrations; elevations in circulating cortisol; mineralocorticoid excess; androgen excess
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Overview
Patients can be both resistant and hypersensitive to glucocorticoids.
In glucocorticoid resistance, the target tissue is unable to respond to glucocorticoids. The lack of responsiveness can be
- Generalized or tissue-specific
- Transient or permanent
- Partial or complete
- Compensated or noncompensated.
The presence of complete glucocorticoid resistance is fatal. Absence of functional glucocorticoid receptors (GRs) in GR -/- knockout mice is associated with death within hours.
Acknowledgements
The content on this page was first contributed by: C. Michael Gibson, M.S., M.D. Template:WH Template:WS