Thrombophilia causes: Difference between revisions
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==Causes== | ==Causes== | ||
===Inherited=== | ===Inherited=== | ||
In a cohort study. the population attributable risk of venous thromboembolism was:<ref name="pmid23382263">{{cite journal| author=Sode BF, Allin KH, Dahl M, Gyntelberg F, Nordestgaard BG| title=Risk of venous thromboembolism and myocardial infarction associated with factor V Leiden and prothrombin mutations and blood type. | journal=CMAJ | year= 2013 | volume= 185 | issue= 5 | pages= E229-37 | pmid=23382263 | doi=10.1503/cmaj.121636 | pmc=PMC3602271 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=23382263 }} </ref> | |||
* 20% for ABO blood type | |||
* 10% for [[factor V Leiden]] R506Q (Activated Protein C Resistance) via G1691A mutation | |||
* 1% for [[prothrombin G20210A]] | |||
Common types: | Common types: | ||
* G1691A mutation in factor V gene ([[Factor V Leiden|Factor V, Leiden type]]; 5% of the population are [[heterozygous]] for FVL) | * G1691A mutation in factor V gene ([[Factor V Leiden|Factor V, Leiden type]]; 5% of the population are [[heterozygous]] for FVL) | ||
Revision as of 02:36, 30 April 2013
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Causes
Inherited
In a cohort study. the population attributable risk of venous thromboembolism was:[1]
- 20% for ABO blood type
- 10% for factor V Leiden R506Q (Activated Protein C Resistance) via G1691A mutation
- 1% for prothrombin G20210A
Common types:
- G1691A mutation in factor V gene (Factor V, Leiden type; 5% of the population are heterozygous for FVL)
- Prothrombin (factor II) mutation (G20210A, 5'UTR)
- Homozygous C677T mutation in the MTHFR gene
Rare forms:
- Plasminogen and fibrinolysis disorders
- Paroxysmal nocturnal hemoglobinuria
- Protein C deficiency
- Protein S deficiency
- Antithrombin III deficiency
- Dysfibrinogenemia
- Homozygous homocystinuria
- Increased levels of factor VIII, factor IX, factor XI, or fibrinogen.
Acquired
- Antiphospholipid antibodies
- Renal disease (renal loss of antithrombin)
- High homocysteine levels due to vitamin deficiency (vitamins B6, B12 and folic acid).
- Immobility
- Pregnancy and puerperium
- Oral contraceptive pills
- Malignancy
- Obesity
- African American race
- Hormone replacement therapy
- Surgery and trauma
- Older age
- Myeloproliferative disorders
- Previous thrombosis
Causes of Thrombophilia by Organ System
References
- ↑ Sode BF, Allin KH, Dahl M, Gyntelberg F, Nordestgaard BG (2013). "Risk of venous thromboembolism and myocardial infarction associated with factor V Leiden and prothrombin mutations and blood type". CMAJ. 185 (5): E229–37. doi:10.1503/cmaj.121636. PMC 3602271. PMID 23382263.