Erdheim-Chester disease laboratory findings: Difference between revisions
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Revision as of 13:53, 21 September 2012
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Erdheim-Chester disease Microchapters |
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Erdheim-Chester disease laboratory findings On the Web |
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Risk calculators and risk factors for Erdheim-Chester disease laboratory findings |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Laboratory Findings
Histologically, ECD differs from Langerhans cell histiocytosis (LCH) in a number of ways. Unlike LCH, ECD does not stain positive for S-100 or CD 1a, and electron microscopy of cell cytoplasm does not disclose Birbeck granules.[1] Tissue samples show xanthomatous or xanthogranulomatous infiltration by lipid-laden or foamy histiocytes, and are usually surrounded by fibrosis. Bone biopsy is said to offer the greatest likelihood of reaching a diagnosis.