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==Overview== | ==Overview== | ||
'''Macrocytosis''' is the enlargement of [[red blood cell]]s with near-constant [[haemoglobin]] concentration, and is defined by a [[mean corpuscular volume]] (MCV) of greater than 100 femtolitres (the precise criterion varies between laboratories). | '''Macrocytosis''' is the enlargement of [[red blood cell]]s with near-constant [[haemoglobin]] concentration, and is defined by a [[mean corpuscular volume]] (MCV) of greater than 100 femtolitres (the precise criterion varies between laboratories). | ||
==Risk factors== | |||
* Folate deficiency | |||
** Nutritionally deficient - Elderly, alcohol, narcotic abuse | |||
** Those with increased demand: [[pregnancy]], [[infancy]], low grade [[hemolysis]], [[malignancy]] or chronic [[hemodialysis]]. | |||
* Pernicious Anemia (PA) is the most common cause of B12 deficiency in the US and is associated with other autoimmune disease such as Hashimoto’s, vitiligo, diabetes, adrenal insufficiency, etc. (Schmitt’s Syndrome). | |||
* Strict Vegans and/or their infants can become B12 deficient from poor intake. | |||
* Patients with malabsorptive disorders such as blind loops/bacterial overgrowth, Sprue, Whipple’s and Crohn’s can malabsorb folate and B12. D.Latum is a competitor for B12 absorption. This entity is most commonly found in Scandinavia. | |||
==References== | ==References== | ||
{{Reflist|2}} | {{Reflist|2}} | ||
Revision as of 14:31, 21 September 2012
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Macrocytosis is the enlargement of red blood cells with near-constant haemoglobin concentration, and is defined by a mean corpuscular volume (MCV) of greater than 100 femtolitres (the precise criterion varies between laboratories).
Risk factors
- Folate deficiency
- Nutritionally deficient - Elderly, alcohol, narcotic abuse
- Those with increased demand: pregnancy, infancy, low grade hemolysis, malignancy or chronic hemodialysis.
- Pernicious Anemia (PA) is the most common cause of B12 deficiency in the US and is associated with other autoimmune disease such as Hashimoto’s, vitiligo, diabetes, adrenal insufficiency, etc. (Schmitt’s Syndrome).
- Strict Vegans and/or their infants can become B12 deficient from poor intake.
- Patients with malabsorptive disorders such as blind loops/bacterial overgrowth, Sprue, Whipple’s and Crohn’s can malabsorb folate and B12. D.Latum is a competitor for B12 absorption. This entity is most commonly found in Scandinavia.
References
gl:Anemia megaloblástica he:אנמיה מגלובלסטית it:Anemia megaloblastica sl:Megaloblastna anemija sr:Мегалобластна анемија