Macrocytic anemia: Difference between revisions

Jump to navigation Jump to search
Line 74: Line 74:


==[[Macrocytic anemia case study one|Case #1]]==
==[[Macrocytic anemia case study one|Case #1]]==
==Treatment==
* Folate is administered 1mg QD.  Higher doses may be required in malabsorptive syndromes.  It is empirically given to those with SCD and those on HD.
* B12 must be given as a load then maintenance.  Most advocate 1000 mcg IM Qweek x4 then 100mcg/month.
* LDH falls in 2 days.  Hypokalemia requiring replacement can occur in the acute phase as new cells are being generated rapidly.
* A reticulocytosis begins in 3-5 days and peaks in 10 days.  The HCT will rise within 10days.  If it does not, suspect another disorder.  Hypersegmented PMNs disappear in 10-14 days.
* Neurologic abnormalities may take up to 6 months to resolve if ever.  The longer the disease has been present, the worse is the prognosis for recovery.
* Persons with PA have a 2x risk of gastric CA (in some studies).  Screen for occult blood.


[[el:Μακροκυτταρική αναιμία]]
[[el:Μακροκυτταρική αναιμία]]

Revision as of 14:46, 21 September 2012

For patient information click here

Macrocytic anemia
Megaloblastic anemia blood smear
ICD-10 D51.1, D52.0, D53.1
ICD-9 281
DiseasesDB 29507
MeSH D000749

Macrocytic anemia Microchapters

Home

Patient Information

Overview

Historical Perspective

Classification

Pathophysiology

Causes

Differentiating Macrocytic anemia from other Diseases

Epidemiology and Demographics

Risk Factors

Screening

Natural History, Complications and Prognosis

Diagnosis

Diagnostic Study of Choice

History and Symptoms

Physical Examination

Laboratory Findings

Electrocardiogram

X-ray

Echocardiography and Ultrasound

CT

MRI

Other Imaging Findings

Other Diagnostic Studies

Treatment

Medical Therapy

Surgery

Primary Prevention

Secondary Prevention

Cost-Effectiveness of Therapy

Future or Investigational Therapies

Case Studies

Case #1

Macrocytic anemia On the Web

Most recent articles

Most cited articles

Review articles

CME Programs

Powerpoint slides

Images

American Roentgen Ray Society Images of Macrocytic anemia

All Images
X-rays
Echo & Ultrasound
CT Images
MRI

Ongoing Trials at Clinical Trials.gov

US National Guidelines Clearinghouse

NICE Guidance

FDA on Macrocytic anemia

CDC on Macrocytic anemia

Macrocytic anemia in the news

Blogs on Macrocytic anemia

Directions to Hospitals Treating Macrocytic anemia

Risk calculators and risk factors for Macrocytic anemia

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor-In-Chief: Cafer Zorkun, M.D., Ph.D. [2]

Overview

Historical Perspective

Classification

Pathophysiology

Causes

Differentiating Macrocytic anemia from other Diseases

Epidemiology and Demographics

Risk Factors

Screening

Natural History, Complications and Prognosis

Diagnosis

History and Symptoms

Physical Examination

Laboratory Findings

Electrocardiogram

Chest X Ray

CT

MRI

Echocardiography or Ultrasound

Other Imaging Findings

Other Diagnostic Studies

Treatment

Medical Therapy

Surgery

Primary Prevention

Secondary Prevention

Cost-Effectiveness of Therapy

Future or Investigational Therapies

Case Studies

Case #1

el:Μακροκυτταρική αναιμία sq:Anemi makrocitike

Template:WikiDoc Sources

References

gl:Anemia megaloblástica he:אנמיה מגלובלסטית it:Anemia megaloblastica sl:Megaloblastna anemija sr:Мегалобластна анемија


Template:WikiDoc Sources