Agranulocytosis laboratory findings: Difference between revisions

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==Overview==
==Laboratory Findings==
The diagnosis is made after a [[complete blood count]], a routine blood testThe absolute neutrophil count in this test will be below 500, and can reach 0 cells/mm³. Other kinds of blood cells are typically present in normal numbers.
 
To formally diagnose agranulocytosis, other pathologies with a similar presentation must be excluded, such as [[aplastic anemia]], [[paroxysmal nocturnal hemoglobinuria]], [[myelodysplasia]] and [[leukemia]]s. This requires a [[bone marrow examination]] that shows normocellular (normal amounts and types of cells) blood marrow with underdeveloped [[promyelocyte]]s. These underdeveloped promyelocytes, if fully matured, would have been the missing granulocytes.
 
==References==
==References==
{{Reflist|2}}
{{Reflist|2}}

Revision as of 15:57, 21 September 2012

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Laboratory Findings

The diagnosis is made after a complete blood count, a routine blood test. The absolute neutrophil count in this test will be below 500, and can reach 0 cells/mm³. Other kinds of blood cells are typically present in normal numbers.

To formally diagnose agranulocytosis, other pathologies with a similar presentation must be excluded, such as aplastic anemia, paroxysmal nocturnal hemoglobinuria, myelodysplasia and leukemias. This requires a bone marrow examination that shows normocellular (normal amounts and types of cells) blood marrow with underdeveloped promyelocytes. These underdeveloped promyelocytes, if fully matured, would have been the missing granulocytes.

References


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