Macrocytic anemia history and symptoms: Difference between revisions
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==Overview== | ==Overview== | ||
==History and Symptoms== | ==History and Symptoms== | ||
The following points should be noted in history: | |||
* Patient age: MCV is higher in neonates and infants. | |||
* Medical history | |||
* Alcohol use | |||
* Medications (eg, anticonvulsants, zidovudine, immunosuppressive agents) – 51 (35 percent) | |||
* Congenital heart disease – 20 (14 percent) | |||
* Down syndrome – 12 (8 percent) | |||
* Reticulocytosis – 11 (8 percent) | |||
* Bone marrow failure/dysplasia – 6 (4 percent) | |||
* Liver disease, thyroid disease [21,47] | |||
* Hemolytic anemias with reticulocytosis and myelodysplastic syndromes (MDS) | |||
* Macrocytosis is a common feature of MDS, especially in older adults | |||
Patients usally show the following symptoms: | |||
* B12 deficiency causes neurologic dysfunction. | |||
* Anemia symptoms such as fatigue, dyspnea, lightheadedess, and anorexia occur | |||
* | * High output cardiac failure | ||
* Angina | |||
* [[Diarrhea]] | |||
* C[[cheilosis|heilosis]] | |||
* | * G[[glossitis|lossitis]] | ||
* Subacute combined degeneration of the dorsal columns. | |||
* Broad based gait | |||
* Ataxic | |||
* Numbness or paresthesias. | |||
* Rhomberg and Babinski’s sign. | |||
* Dementia may progress to frank “Megaloblastic Madness” | |||
==References== | ==References== | ||
Revision as of 19:12, 5 November 2018
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
History and Symptoms
The following points should be noted in history:
- Patient age: MCV is higher in neonates and infants.
- Medical history
- Alcohol use
- Medications (eg, anticonvulsants, zidovudine, immunosuppressive agents) – 51 (35 percent)
- Congenital heart disease – 20 (14 percent)
- Down syndrome – 12 (8 percent)
- Reticulocytosis – 11 (8 percent)
- Bone marrow failure/dysplasia – 6 (4 percent)
- Liver disease, thyroid disease [21,47]
- Hemolytic anemias with reticulocytosis and myelodysplastic syndromes (MDS)
- Macrocytosis is a common feature of MDS, especially in older adults
Patients usally show the following symptoms:
- B12 deficiency causes neurologic dysfunction.
- Anemia symptoms such as fatigue, dyspnea, lightheadedess, and anorexia occur
- High output cardiac failure
- Angina
- Diarrhea
- Cheilosis
- Glossitis
- Subacute combined degeneration of the dorsal columns.
- Broad based gait
- Ataxic
- Numbness or paresthesias.
- Rhomberg and Babinski’s sign.
- Dementia may progress to frank “Megaloblastic Madness”