Cyanosis differential diagnosis

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Differential Diagnosis of Central Cyanosis

• Abnormal hemoglobin
• Acute respiratory distress syndrome
• Alveolitis
• Atelectasis
• Atrial septal defect
• Bronchiectasis
• Central or peripheral respiratory paralysis
• Chronic bronchitis
• Congenital heart disease
• Decreased respiration with oversedation
• Double outlet right ventricle
• Emphysema
  
• Foreign-body aspiration
• High altitude exposure
• Hypersensitivity pneumonitis
• Intoxication
• Intrapulmonary arteriovenous aneurysms
• Lung cancer
• Mediastinitis
• Patent ductus arteriosus
• Pickwickian syndrome
• Pleural Effusions
• Pneumoconiosis
• Poliomyelitis
• Polyneuropathy
• Primary alveolar hypoventilation
• Pulmonary arteriovenous fistulas
• Pulmonary edema
• Pulmonary embolism
• Pulmonary fibrosis
• Pulmonary hypertension
• Severe chronic obstructive pulmonary disease (COPD) or asthma
• Severe pneumonia
• Single ventricle
• Sleep apnea
• Tension pneumothorax
• Tetralogy of Fallot
• Toxins/poisons
  
• Transposition of the great vessels
• Tuberculosis
• Ventricular septal defect

Differential Diagnosis of Peripheral Cyanosis

• Acrocyanosis
• Arterial embolism
• Arrhythmia
• Cardiomyopathy
• Cold exposure
• Congenital Heart Disease
• Congestive Heart Failure
• Endomyocardial fibrosis
• Heart tumors
• Hypertensive heart disease
• Mitral Stenosis
• Pericardial effusion
• Polycythemia vera
• Raynaud's Phenomenon
• Shock
• Superior vena cava obstruction
• Valvular disease
• Venous hypertension
• Venous stasis