Cardiovascular pharmacology

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Clinical Trials
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Guidelines / Policies / Govt
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Definitions of Cardiovascular pharmacology
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Continuing Medical Education (CME)
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Experimental / Informatics
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Scope

• 5% of questions of the boards

Pharmacokinetics

• Potency vs Efficacy: Potency is meaningless, effect of drug per mg. Efficacy is the clinical effectiveness of drug.
• PK is effect of the body on the drug.
• Drug distribution: muscle high in water content. Women have less muscle mass. Older patients have less muscle mass. Elderly women have less total body water. Water soluble drugs are associated with a higher drug effect (eaxample alcohool). Do not diffuse into brain. Very important in beta blockers, they are hydrophilic.
• Lipophilic drugs:Cross into CNS. Lopressor, propranolol

Hydrophilic

• In intravascular space
• Cleared by kidney
• Dont cross blood brain barrier

Atenolol, hadolol, sotalol

Intestinal Metabolism

• grapefruit juice affects intestinal system, but not liver. Intestinal cytochrome CYP3A4. (dihydropiridine CCBs,

lova, simva, cyclosporine, tacrolimus, sildenafil can be affected. May increase drug levels

Hepatic Metabolims

• beta blockers reduce hepatic blood flow, deompensated CHF affects liver blood flow

Know inhibitors\ allopurinal cipr cimet dilt eryth isoiz PPI

Inducers barb carb Know Inducers