QT prolongation: Difference between revisions
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{{SI}} | {{SI}} | ||
{{CMG}} | {{CMG}} | ||
{{SK}} Prolonged QT | {{SK}} Prolonged QT | ||
==Overview== | ==Overview== | ||
QT prolongation is often caused by drugs, genetic abnormalities, and electrolyte disturbances. | |||
==Causes== | |||
===Common Causes=== | |||
*Drugs | |||
*Genetic abnormalities | |||
*Electrolyte disturbances such as [[hyperkalaemia]], [[hypocalcaemia]], [[hypoglycaemia]], [[hypokalaemia]], [[hypomagnesemia]] | |||
===Causes by Organ System=== | |||
{|style="width:80%; height:100px" border="1" | |||
|style="height:100px"; style="width:25%" border="1" bgcolor="LightSteelBlue" | '''Cardiovascular''' | |||
|style="height:100px"; style="width:75%" border="1" bgcolor="Beige" | [[Ischaemic heart disease]], [[Andersen cardiodysrhythmic periodic paralysis]], [[Jervell and Lange-Nielsen syndrome]], [[Romano-Ward syndrome]], [[Timothy syndrome]] | |||
|- | |||
|-bgcolor="LightSteelBlue" | |||
| '''Chemical / poisoning''' | |||
|bgcolor="Beige"| [[Arsenicals]] | |||
|- | |||
|-bgcolor="LightSteelBlue" | |||
| '''Dermatologic''' | |||
|bgcolor="Beige"| No underlying causes | |||
|- | |||
|-bgcolor="LightSteelBlue" | |||
| '''Drug Side Effect''' | |||
|bgcolor="Beige"| [[Alimemazine]], [[Almokalant]], [[Amiodarone]], [[Amitriptyline]], [[Arsenic trioxide]], [[Asenapine]], [[Astemizole]], [[Azimilide]], [[Azithromycin]], [[Bepridil]], [[Bretylium]], [[Budipine]], [[Chloroquine]], [[Cibenzoline]], [[Cisapride]], [[Citalopram]], [[Clomipramine]], [[Clozapine]], [[Crizotinib]], [[Desipramine]], [[Diphenhydramine]], [[Disopyramide]], [[Dofetilide]], [[Dolasetron]], [[Doxepin]], [[Dronedarone]], [[Droperidol]], [[Eribulin mesylate]], [[Fluconazole]], [[Grepafloxacin]], [[Halofantrine]], [[Haloperidol]], [[Ibutilide]], [[Imipramine]], [[Indapamide]], [[Ketanserin]], [[Ketoconazole]], [[Lidoflazine]], [[Lubeluzole]], [[Methadone]], [[Methadyl acetate]], [[Midodrine]], [[Mizolastine]], [[Moxifloxacin]], [[Naratriptan]], [[Nicardipine]], [[Nilotinib]], [[Ondansetron]], [[Pasireotide]], [[Pazopanib]], [[Pentamidine]], [[Pimozide]], [[Piperaquine]], [[Prenylamine]], [[Probucol]], [[Procainamide]], [[Propoxyphene]], [[Quinidine]], [[Quinine]], [[Ranolazine]], [[Retigabine]], [[Ritodrine]], [[Ritonavir]], [[Saquinavir]], [[Sertindole]], [[Sotalol]], [[Sparfloxacin]], [[Tedisamil]], [[Telithromycin]], [[Terfenadine]], [[Terodiline]], [[Tetrabenazine]], [[Thioridazine]], [[Vandetanib]], [[Vemurafenib]], [[Venlafaxine]], [[Vernakalant]], [[Voriconazole]], [[Vorinostat]], [[Ziprasidone]], [[Zotepine]], [[Zuclopenthixol]] | |||
|- | |||
|-bgcolor="LightSteelBlue" | |||
| '''Ear Nose Throat''' | |||
|bgcolor="Beige"| No underlying causes | |||
|- | |||
|-bgcolor="LightSteelBlue" | |||
| '''Endocrine''' | |||
|bgcolor="Beige"| [[Hypothyroidism]] | |||
|- | |||
|-bgcolor="LightSteelBlue" | |||
| '''Environmental''' | |||
|bgcolor="Beige"| [[Zero gravity]] | |||
|- | |||
|-bgcolor="LightSteelBlue" | |||
| '''Gastroenterologic''' | |||
|bgcolor="Beige"| No underlying causes | |||
|- | |||
|-bgcolor="LightSteelBlue" | |||
| '''Genetic''' | |||
|bgcolor="Beige"| [[Andersen cardiodysrhythmic periodic paralysis]], [[Jervell and Lange-Nielsen syndrome]], [[Myotonic dystrophy]], [[Romano-Ward syndrome]], [[Timothy syndrome]] | |||
|- | |||
|-bgcolor="LightSteelBlue" | |||
| '''Hematologic''' | |||
|bgcolor="Beige"| No underlying causes | |||
|- | |||
|-bgcolor="LightSteelBlue" | |||
| '''Iatrogenic''' | |||
|bgcolor="Beige"| No underlying causes | |||
|- | |||
|-bgcolor="LightSteelBlue" | |||
| '''Infectious Disease''' | |||
|bgcolor="Beige"| No underlying causes | |||
|- | |||
|-bgcolor="LightSteelBlue" | |||
| '''Musculoskeletal / Ortho''' | |||
|bgcolor="Beige"| [[Myotonic dystrophy]], [[Andersen cardiodysrhythmic periodic paralysis]], [[Timothy syndrome]] | |||
|- | |||
|-bgcolor="LightSteelBlue" | |||
| '''Neurologic''' | |||
|bgcolor="Beige"| No underlying causes | |||
|- | |||
|-bgcolor="LightSteelBlue" | |||
| '''Nutritional / Metabolic''' | |||
|bgcolor="Beige"| [[Acute starvation]], [[Anorexia nervosa]], [[Hyperkalaemia]], [[Hypocalcaemia]], [[Hypoglycaemia]], [[Hypokalaemia]], [[Hypomagnesemia]] | |||
|- | |||
|-bgcolor="LightSteelBlue" | |||
| '''Obstetric/Gynecologic''' | |||
|bgcolor="Beige"| No underlying causes | |||
|- | |||
|-bgcolor="LightSteelBlue" | |||
| '''Oncologic''' | |||
|bgcolor="Beige"| No underlying causes | |||
|- | |||
|-bgcolor="LightSteelBlue" | |||
| '''Opthalmologic''' | |||
|bgcolor="Beige"| No underlying causes | |||
|- | |||
|-bgcolor="LightSteelBlue" | |||
| '''Overdose / Toxicity''' | |||
|bgcolor="Beige"| [[Alimemazine]], [[Almokalant]], [[Amiodarone]], [[Amitriptyline]], [[Arsenic trioxide]], [[Asenapine]], [[Astemizole]], [[Azimilide]], [[Azithromycin]], [[Bepridil]], [[Bretylium]], [[Budipine]], [[Chloroquine]], [[Cibenzoline]], [[Cisapride]], [[Citalopram]], [[Clomipramine]], [[Clozapine]], [[Crizotinib]], [[Desipramine]], [[Diphenhydramine]], [[Disopyramide]], [[Dofetilide]], [[Dolasetron]], [[Doxepin]], [[Dronedarone]], [[Droperidol]], [[Eribulin mesylate]], [[Fluconazole]], [[Grepafloxacin]], [[Halofantrine]], [[Haloperidol]], [[Ibutilide]], [[Imipramine]], [[Indapamide]], [[Ketanserin]], [[Ketoconazole]], [[Lidoflazine]], [[Lubeluzole]], [[Methadone]], [[Methadyl acetate]], [[Midodrine]], [[Mizolastine]], [[Moxifloxacin]], [[Naratriptan]], [[Nicardipine]], [[Nilotinib]], [[Ondansetron]], [[Pasireotide]], [[Pazopanib]], [[Pentamidine]], [[Pimozide]], [[Piperaquine]], [[Prenylamine]], [[Probucol]], [[Procainamide]], [[Propoxyphene]], [[Quinidine]], [[Quinine]], [[Ranolazine]], [[Retigabine]], [[Ritodrine]], [[Ritonavir]], [[Saquinavir]], [[Sertindole]], [[Sotalol]], [[Sparfloxacin]], [[Tedisamil]], [[Telithromycin]], [[Terfenadine]], [[Terodiline]], [[Tetrabenazine]], [[Thioridazine]], [[Vandetanib]], [[Vemurafenib]], [[Venlafaxine]], [[Vernakalant]], [[Voriconazole]], [[Vorinostat]], [[Ziprasidone]], [[Zotepine]], [[Zuclopenthixol]] | |||
|- | |||
|-bgcolor="LightSteelBlue" | |||
| '''Psychiatric''' | |||
|bgcolor="Beige"| [[Anorexia nervosa]], [[Timothy syndrome]] | |||
|- | |||
|-bgcolor="LightSteelBlue" | |||
| '''Pulmonary''' | |||
|bgcolor="Beige"| No underlying causes | |||
|- | |||
|-bgcolor="LightSteelBlue" | |||
| '''Renal / Electrolyte''' | |||
|bgcolor="Beige"| No underlying causes | |||
|- | |||
|-bgcolor="LightSteelBlue" | |||
| '''Rheum / Immune / Allergy''' | |||
|bgcolor="Beige"| No underlying causes | |||
|- | |||
|-bgcolor="LightSteelBlue" | |||
| '''Sexual''' | |||
|bgcolor="Beige"| No underlying causes | |||
|- | |||
|-bgcolor="LightSteelBlue" | |||
| '''Trauma''' | |||
|bgcolor="Beige"| No underlying causes | |||
|- | |||
|-bgcolor="LightSteelBlue" | |||
| '''Urologic''' | |||
|bgcolor="Beige"| No underlying causes | |||
|- | |||
|-bgcolor="LightSteelBlue" | |||
| '''Dental''' | |||
|bgcolor="Beige"| No underlying causes | |||
|- | |||
|-bgcolor="LightSteelBlue" | |||
| '''Miscellaneous''' | |||
|bgcolor="Beige"| [[Hypothermia]], [[Acute starvation]] | |||
|- | |||
|} | |||
===Causes in Alphabetical Order=== | |||
{{MultiCol}} | |||
*[[Acute starvation]] | |||
*[[Alimemazine]] | |||
*[[Almokalant]] | |||
*[[Amiodarone]] | |||
*[[Amitriptyline]] | |||
*[[Andersen cardiodysrhythmic periodic paralysis]] | |||
*[[Anorexia nervosa]] | |||
*[[Arsenic trioxide]] | |||
*[[Arsenicals]] | |||
*[[Asenapine]] | |||
*[[Astemizole]] | |||
*[[Azimilide]] | |||
*[[Azithromycin]] | |||
*[[Bepridil]] | |||
*[[Bretylium]] | |||
*[[Budipine]] | |||
*[[Chloroquine]] | |||
*[[Cibenzoline]] | |||
*[[Cisapride]] | |||
*[[Citalopram]] | |||
*[[Clomipramine]] | |||
*[[Clozapine]] | |||
*[[Crizotinib]] | |||
*[[Desipramine]] | |||
*[[Diphenhydramine]] | |||
*[[Disopyramide]] | |||
*[[Dofetilide]] | |||
*[[Dolasetron]] | |||
*[[Doxepin]] | |||
*[[Dronedarone]] | |||
*[[Droperidol]] | |||
*[[Eribulin mesylate]] | |||
*[[Fluconazole]] | |||
*[[Grepafloxacin]] | |||
*[[Halofantrine]] | |||
*[[Haloperidol]] | |||
*[[Hyperkalaemia]] | |||
*[[Hypocalcaemia]] | |||
*[[Hypoglycaemia]] | |||
*[[Hypokalaemia]] | |||
*[[Hypomagnesemia]] | |||
*[[Hypothermia]] | |||
*[[Hypothyroidism]] | |||
*[[Ibutilide]] | |||
*[[Imipramine]] | |||
*[[Indapamide]] | |||
*[[Ischaemic heart disease]] | |||
*[[Jervell and Lange-Nielsen syndrome]] | |||
*[[Ketanserin]] | |||
*[[Ketoconazole]] | |||
{{ColBreak}} | |||
*[[Lidoflazine]] | |||
*[[Lubeluzole]] | |||
*[[Methadone]] | |||
*[[Methadyl acetate]] | |||
*[[Midodrine]] | |||
*[[Mizolastine]] | |||
*[[Moxifloxacin]] | |||
*[[Myotonic dystrophy]] | |||
*[[Naratriptan]] | |||
*[[Nicardipine]] | |||
*[[Nilotinib]] | |||
*[[Ondansetron]] | |||
*[[Pasireotide]] | |||
*[[Pazopanib]] | |||
*[[Pentamidine]] | |||
*[[Pimozide]] | |||
*[[Piperaquine]] | |||
*[[Prenylamine]] | |||
*[[Probucol]] | |||
*[[Procainamide]] | |||
*[[Propoxyphene]] | |||
*[[Quinidine]] | |||
*[[Quinine]] | |||
*[[Ranolazine]] | |||
*[[Retigabine]] | |||
*[[Ritodrine]] | |||
*[[Ritonavir]] | |||
*[[Romano-Ward syndrome]] | |||
*[[Saquinavir]] | |||
*[[Sertindole]] | |||
*[[Sotalol]] | |||
*[[Sparfloxacin]] | |||
*[[Tedisamil]] | |||
*[[Telithromycin]] | |||
*[[Terfenadine]] | |||
*[[Terodiline]] | |||
*[[Tetrabenazine]] | |||
*[[Thioridazine]] | |||
*[[Timothy syndrome]] | |||
*[[Vandetanib]] | |||
*[[Vemurafenib]] | |||
*[[Venlafaxine]] | |||
*[[Vernakalant]] | |||
*[[Voriconazole]] | |||
*[[Vorinostat]] | |||
*[[Zero gravity]] | |||
*[[Ziprasidone]] | |||
*[[Zotepine]] | |||
*[[Zuclopenthixol]] | |||
{{EndMultiCol}} | |||
==References== | ==References== | ||
{{Reflist|2}} | {{Reflist|2}} | ||
[[Category:Differential diagnosis]] | |||
[[Category:Cardiology]] | [[Category:Cardiology]] | ||
[[Category:Electrophysiology]] | [[Category:Electrophysiology]] |
Revision as of 01:16, 2 October 2012
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Synonyms and keywords: Prolonged QT
Overview
QT prolongation is often caused by drugs, genetic abnormalities, and electrolyte disturbances.
Causes
Common Causes
- Drugs
- Genetic abnormalities
- Electrolyte disturbances such as hyperkalaemia, hypocalcaemia, hypoglycaemia, hypokalaemia, hypomagnesemia
Causes by Organ System
Causes in Alphabetical Order