LQT4: Difference between revisions
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==LQT4 Subtype== | ==LQT4 Subtype== | ||
{| class="wikitable" | |||
| '''Type''' || '''OMIM''' || '''Mutation''' || '''Notes''' | |||
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| [[LQT4]] || {{OMIM2|600919}} || anchor protein [[Ankyrin B]] || LQT4 is very rare. Ankyrin B anchors the ion channels in the cell. | |||
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The LQT4 genes are ANK2 and ANKB, and code for proteins called [[ankyrins]]. They are proteins which bind to several important ion channel proteins such as the chloride-bicarbonate anion exchanger, [[ATPase]], calcium release channels, and the voltage gated sodium channel. A mutation in the LTQ4 genes that code for ankyrins can cause increased intracellular concentrations of [[calcium]], and can therefore cause fatal [[arrhythmia]]s. | The LQT4 genes are ANK2 and ANKB, and code for proteins called [[ankyrins]]. They are proteins which bind to several important ion channel proteins such as the chloride-bicarbonate anion exchanger, [[ATPase]], calcium release channels, and the voltage gated sodium channel. A mutation in the LTQ4 genes that code for ankyrins can cause increased intracellular concentrations of [[calcium]], and can therefore cause fatal [[arrhythmia]]s. | ||
Revision as of 18:06, 2 October 2012
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Long QT Syndrome Microchapters |
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Diagnosis |
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Treatment |
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Case Studies |
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LQT4 On the Web |
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American Roentgen Ray Society Images of LQT4 |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [2]
Overview
LQT4 Subtype
| Type | OMIM | Mutation | Notes |
| LQT4 | 600919 | anchor protein Ankyrin B | LQT4 is very rare. Ankyrin B anchors the ion channels in the cell. |
The LQT4 genes are ANK2 and ANKB, and code for proteins called ankyrins. They are proteins which bind to several important ion channel proteins such as the chloride-bicarbonate anion exchanger, ATPase, calcium release channels, and the voltage gated sodium channel. A mutation in the LTQ4 genes that code for ankyrins can cause increased intracellular concentrations of calcium, and can therefore cause fatal arrhythmias.