Zygomycosis history and symptoms: Difference between revisions
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{{Zygomycosis}} | {{Zygomycosis}} | ||
{{CMG}} | {{CMG}} | ||
==Overview== | ==Overview== | ||
==History and symptoms== | ==History and symptoms== | ||
Mucormycosis frequently involves the [[Paranasal sinus|sinuses]], [[brain]], or [[lungs]] as the sites of infection. Whilst orbitorhinocerebral mucormycosis is the most common type of the disease, this infection can also manifest in the [[gastrointestinal tract]], [[skin]], and in other organ systems. | Mucormycosis frequently involves the [[Paranasal sinus|sinuses]], [[brain]], or [[lungs]] as the sites of infection. Whilst orbitorhinocerebral mucormycosis is the most common type of the disease, this infection can also manifest in the [[gastrointestinal tract]], [[skin]], and in other organ systems. The clinical [[hallmark]] of mucormycosis is [[vascular]] invasion resulting in [[thrombosis]] and tissue [[infarction]]/[[necrosis]]. | ||
If rhinocerebral disease is the cause of the infection, symptoms may include [[unilateral]], retro-orbital [[headache]], facial pain, [[fevers]], nasal stuffiness that progresses to black [[discharge]], acute sinusitis, and eye swelling along with protrusion of eye orbit. | If rhinocerebral disease is the cause of the infection, symptoms may include [[unilateral]], retro-orbital [[headache]], facial pain, [[fevers]], nasal stuffiness that progresses to black [[discharge]], acute sinusitis, and eye swelling along with protrusion of eye orbit. In addition, affected skin may appear relatively normal during the earliest stages of infection. This skin quickly progresses to an [[erythemic]] (reddening, occasionally with [[edema]]) stage, before eventually turning black due to necrosis.<ref name=cmrasm>{{cite journal |author=Spellberg B, Edwards J, Ibrahim A |title=Novel perspectives on mucormycosis: pathophysiology, presentation, and management |journal=Clin. Microbiol. Rev. |volume=18 |issue=3 |pages=556–69 |year=2005 |pmid=16020690 |doi=10.1128/CMR.18.3.556-569.2005| url=http://cmr.asm.org/cgi/content/full/18/3/556}} {{PMC|1195964}}</ref> However, in other forms of mucormycosis (such as pulmonary, cutaneous or disseminated mucormycosis), symptoms may also include [[dyspnea]], persistent [[cough]], [[hemoptysis]] (in cases of necrosis and [[nausea]]/[[vomiting]]), coughing blood, and abdominal pain. | ||
Rarely, [[maxilla]] may be affected by mucormycosis. | Rarely, [[maxilla]] may be affected by mucormycosis. The lack of case reports regarding maxillofacial mucormycosis lies in the rich vascularity of the maxillofacial areas preventing fungal infections, although this can be overcome by more prevalent fungi, bacteria or viruses such as those responsible for mucormycosis. | ||
Predisposing factors for mucormycosis include [[AIDS]], malignancies such as [[lymphoma]]s and [[leukemia]]s, [[renal failure]], [[organ transplant]], long term [[corticosteroid]] and immunosuppressive therapy, [[cirrhosis]], [[burns]] and energy [[malnutrition]]. | Predisposing factors for mucormycosis include [[AIDS]], malignancies such as [[lymphoma]]s and [[leukemia]]s, [[renal failure]], [[organ transplant]], long term [[corticosteroid]] and immunosuppressive therapy, [[cirrhosis]], [[burns]] and energy [[malnutrition]]. | ||
Possible complications of mucormycosis include the partial loss of neurological function, blindness and clotting of brain or lung vessels. | Possible complications of mucormycosis include the partial loss of neurological function, blindness and clotting of brain or lung vessels. | ||
Basidiobolomycosis is usually a superficial infection of skin, but may very rarely cause lesions of the bowel or liver, mimicking bowel cancer,<ref>{{cite journal | title=A fatal pseudo-tumour: disseminated basidiobolomycosis | author=Van den berk GEL, Noorduyn LA, van Ketel RJ, ''et al.'' | journal=BMC Infect Dis | year=2006 | volume=6 | pages=140 | doi=10.1186/1471-2334-6-140 }}</ref> or [[Crohn's disease]].<ref>{{cite journal | journal=Clin Infect Dis | year=1999 | volume=28 | issue=6 | pages=1244–8 | title=Gastrointestinal zygomycotic infection caused by ''Basidiobolus ranarum:'' case report and review | author=Zavasky DM, Samowitz W, Loftus T, Segal H, Carroll K }}</ref> In patients with deep involvement, the [[eosinophil]] count may be raised, falsely suggesting a parasitic infection. | Basidiobolomycosis is usually a superficial infection of skin, but may very rarely cause lesions of the bowel or liver, mimicking bowel cancer,<ref>{{cite journal | title=A fatal pseudo-tumour: disseminated basidiobolomycosis | author=Van den berk GEL, Noorduyn LA, van Ketel RJ, ''et al.'' | journal=BMC Infect Dis | year=2006 | volume=6 | pages=140 | doi=10.1186/1471-2334-6-140 }}</ref> or [[Crohn's disease]].<ref>{{cite journal | journal=Clin Infect Dis | year=1999 | volume=28 | issue=6 | pages=1244–8 | title=Gastrointestinal zygomycotic infection caused by ''Basidiobolus ranarum:'' case report and review | author=Zavasky DM, Samowitz W, Loftus T, Segal H, Carroll K }}</ref> In patients with deep involvement, the [[eosinophil]] count may be raised, falsely suggesting a parasitic infection. | ||
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
History and symptoms
Mucormycosis frequently involves the sinuses, brain, or lungs as the sites of infection. Whilst orbitorhinocerebral mucormycosis is the most common type of the disease, this infection can also manifest in the gastrointestinal tract, skin, and in other organ systems. The clinical hallmark of mucormycosis is vascular invasion resulting in thrombosis and tissue infarction/necrosis.
If rhinocerebral disease is the cause of the infection, symptoms may include unilateral, retro-orbital headache, facial pain, fevers, nasal stuffiness that progresses to black discharge, acute sinusitis, and eye swelling along with protrusion of eye orbit. In addition, affected skin may appear relatively normal during the earliest stages of infection. This skin quickly progresses to an erythemic (reddening, occasionally with edema) stage, before eventually turning black due to necrosis.[1] However, in other forms of mucormycosis (such as pulmonary, cutaneous or disseminated mucormycosis), symptoms may also include dyspnea, persistent cough, hemoptysis (in cases of necrosis and nausea/vomiting), coughing blood, and abdominal pain.
Rarely, maxilla may be affected by mucormycosis. The lack of case reports regarding maxillofacial mucormycosis lies in the rich vascularity of the maxillofacial areas preventing fungal infections, although this can be overcome by more prevalent fungi, bacteria or viruses such as those responsible for mucormycosis.
Predisposing factors for mucormycosis include AIDS, malignancies such as lymphomas and leukemias, renal failure, organ transplant, long term corticosteroid and immunosuppressive therapy, cirrhosis, burns and energy malnutrition.
Possible complications of mucormycosis include the partial loss of neurological function, blindness and clotting of brain or lung vessels.
Basidiobolomycosis is usually a superficial infection of skin, but may very rarely cause lesions of the bowel or liver, mimicking bowel cancer,[2] or Crohn's disease.[3] In patients with deep involvement, the eosinophil count may be raised, falsely suggesting a parasitic infection.
References
- ↑ Spellberg B, Edwards J, Ibrahim A (2005). "Novel perspectives on mucormycosis: pathophysiology, presentation, and management". Clin. Microbiol. Rev. 18 (3): 556–69. doi:10.1128/CMR.18.3.556-569.2005. PMID 16020690. PMC 1195964
- ↑ Van den berk GEL, Noorduyn LA, van Ketel RJ; et al. (2006). "A fatal pseudo-tumour: disseminated basidiobolomycosis". BMC Infect Dis. 6: 140. doi:10.1186/1471-2334-6-140.
- ↑ Zavasky DM, Samowitz W, Loftus T, Segal H, Carroll K (1999). "Gastrointestinal zygomycotic infection caused by Basidiobolus ranarum: case report and review". Clin Infect Dis. 28 (6): 1244&ndash, 8.