Schizophrenia future or investigational therapies: Difference between revisions
Created page with "__NOTOC__ {{Schizophrenia}} {{CMG}} ==Overview== ==Future or Investigational Therapies== Service-user led movements have become integral to the recovery process in [[Europe]..." |
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''American Journal of Orthopsychiatry'', 76 (3), 367-73. PMID 16981815</ref> | ''American Journal of Orthopsychiatry'', 76 (3), 367-73. PMID 16981815</ref> | ||
===The Soteria Model=== | |||
The [[Soteria]] model is an alternative treatment to institutionalization and early use of antipsychotics.<ref>{{cite journal | author = Bola JR, Mosher LR | title = Treatment of Acute Psychosis Without Neuroleptics: Two-Year Outcomes From the Soteria Project | journal = The Journal of Nervous and Mental Disease | publisher = Lippincott Williams & Wilkins, Inc | volume = 191 | pages = 219–229 | date = April 2003 | url = http://www.moshersoteria.com/bola.pdf | format=PDF | pmid=12695732|accessdate=2007-06-13}}</ref> It is described as a [[Social environment|milieu]]-therapeutic [[psychosocial recovery|recovery]] method, characterized by its founder as "the 24 hour a day application of interpersonal phenomenologic interventions by a nonprofessional staff, usually without neuroleptic drug treatment, in the context of a small, homelike, quiet, supportive, protective, and tolerant social environment."<ref name="mosh99">Mosher LR (1999). "Soteria and Other Alternatives to Acute Psychiatric Hospitalization: A Personal and Professional Review." Journal of Nervous and Mental Disease, 187, 142–149.</ref> Soteria or Soteria-based houses are currently run in Sweden,<ref>Perris, C.M. Cognitive Therapy with Schizophrenic Patients. Guilford, New York, NY, 1989.</ref> Germany,<ref>[http://www.zfp-web.de/K3/html/artikel.php3?path=0:3:32:138&a_id=83 Allgemeine Psychiatrie I / Soteria]</ref><ref>[http://www.toll-haus.de/index.html Toll - Haus]</ref><ref>[http://www.lunaticpride.de/SOTERIA.HTM Soteria]</ref> Switzerland,<ref>[http://www.soteria.ch Soteria Bern]</ref> and Hungary.<ref>[http://www.soteria.hu/ Soteria Alapítvány]</ref> The Soteria house in [[Berne]], Switzerland is associated with a psychiatrist who teaches at the [[University of Berne]], and has been featured in the ''Schweizerische Aertzezeitung'', the Bulletin of Swiss Physicians.<ref>http://www.soteria.ch/pdf/Soteria%20Bern%20SAEZ.pdf Soteria</ref> | The [[Soteria]] model is an alternative treatment to institutionalization and early use of antipsychotics.<ref>{{cite journal | author = Bola JR, Mosher LR | title = Treatment of Acute Psychosis Without Neuroleptics: Two-Year Outcomes From the Soteria Project | journal = The Journal of Nervous and Mental Disease | publisher = Lippincott Williams & Wilkins, Inc | volume = 191 | pages = 219–229 | date = April 2003 | url = http://www.moshersoteria.com/bola.pdf | format=PDF | pmid=12695732|accessdate=2007-06-13}}</ref> It is described as a [[Social environment|milieu]]-therapeutic [[psychosocial recovery|recovery]] method, characterized by its founder as "the 24 hour a day application of interpersonal phenomenologic interventions by a nonprofessional staff, usually without neuroleptic drug treatment, in the context of a small, homelike, quiet, supportive, protective, and tolerant social environment."<ref name="mosh99">Mosher LR (1999). "Soteria and Other Alternatives to Acute Psychiatric Hospitalization: A Personal and Professional Review." Journal of Nervous and Mental Disease, 187, 142–149.</ref> Soteria or Soteria-based houses are currently run in Sweden,<ref>Perris, C.M. Cognitive Therapy with Schizophrenic Patients. Guilford, New York, NY, 1989.</ref> Germany,<ref>[http://www.zfp-web.de/K3/html/artikel.php3?path=0:3:32:138&a_id=83 Allgemeine Psychiatrie I / Soteria]</ref><ref>[http://www.toll-haus.de/index.html Toll - Haus]</ref><ref>[http://www.lunaticpride.de/SOTERIA.HTM Soteria]</ref> Switzerland,<ref>[http://www.soteria.ch Soteria Bern]</ref> and Hungary.<ref>[http://www.soteria.hu/ Soteria Alapítvány]</ref> The Soteria house in [[Berne]], Switzerland is associated with a psychiatrist who teaches at the [[University of Berne]], and has been featured in the ''Schweizerische Aertzezeitung'', the Bulletin of Swiss Physicians.<ref>http://www.soteria.ch/pdf/Soteria%20Bern%20SAEZ.pdf Soteria</ref> | ||
===Orthomolecular Psychiatry=== | |||
The biologically based branch of [[alternative medicine]] that deals with schizophrenia is known as [[orthomolecular psychiatry]]. Some scientists claim that schizophrenia can be treated effectively with nutrients like [[niacin]], vitamin C and B<sub>6</sub>, omega-3 EFAs (fish oil) along with various minerals and amino acids.<ref>Hoffer and Walker, ''Orthomolecular Nutrition''. Keats Publishing, 1978</ref><ref>Abram Hoffer (1999) [http://books.google.com/books?id=wT4HUH3Vgg8C&pg=PA29&lpg=PA29&dq=%22orthomolecular+treatment+for+schizophrenia%22+(fish%7Comega)+hoffer&source=web&ots=0sX_JFtan7&sig=2407TmHj7yudMqA4vJKYcI3hGeo#PPA32,M1 Orthomolecular treatment for Schizophrenia], McGraw-Hill, ISBN 0879839104</ref> The body's adverse reactions to [[gluten]] and other allergens are [[gluten-free, casein-free diet|implicated in some alternative theories]] as the cause of some cases. This theory—discussed by one author in three British journals in the 1970s<ref> Dohan FC (1970). Coeliac disease and schizophrenia. ''Lancet'', 1970 April 25;1(7652):897–8. PMID 4191543<br />*Dohan FC (1973). Coeliac disease and schizophrenia. ''British Medical Journal'', 3(5870): 51–52. PMID 4740433<br />* Dohan FC (1979). Celiac-type diets in schizophrenia. '' Am J Psychiatry'', 1979 May;136(5):732–3. PMID 434265</ref>—is unproven. A 2006 literature review suggests that gluten may be a factor for a subset of patients with schizophrenia, but further study is needed to confirm the association between gluten and schizophrenia.<ref name="Kalaydjian_AE"> Kalaydjian AE, Eaton W, Cascella N, Fasano A (2006). The gluten connection: the association between schizophrenia and celiac disease. ''[[Acta Psychiatrica Scandinavica]]'' 2006 Feb;113(2):82–90. PMID 16423158</ref> | The biologically based branch of [[alternative medicine]] that deals with schizophrenia is known as [[orthomolecular psychiatry]]. Some scientists claim that schizophrenia can be treated effectively with nutrients like [[niacin]], vitamin C and B<sub>6</sub>, omega-3 EFAs (fish oil) along with various minerals and amino acids.<ref>Hoffer and Walker, ''Orthomolecular Nutrition''. Keats Publishing, 1978</ref><ref>Abram Hoffer (1999) [http://books.google.com/books?id=wT4HUH3Vgg8C&pg=PA29&lpg=PA29&dq=%22orthomolecular+treatment+for+schizophrenia%22+(fish%7Comega)+hoffer&source=web&ots=0sX_JFtan7&sig=2407TmHj7yudMqA4vJKYcI3hGeo#PPA32,M1 Orthomolecular treatment for Schizophrenia], McGraw-Hill, ISBN 0879839104</ref> The body's adverse reactions to [[gluten]] and other allergens are [[gluten-free, casein-free diet|implicated in some alternative theories]] as the cause of some cases. This theory—discussed by one author in three British journals in the 1970s<ref> Dohan FC (1970). Coeliac disease and schizophrenia. ''Lancet'', 1970 April 25;1(7652):897–8. PMID 4191543<br />*Dohan FC (1973). Coeliac disease and schizophrenia. ''British Medical Journal'', 3(5870): 51–52. PMID 4740433<br />* Dohan FC (1979). Celiac-type diets in schizophrenia. '' Am J Psychiatry'', 1979 May;136(5):732–3. PMID 434265</ref>—is unproven. A 2006 literature review suggests that gluten may be a factor for a subset of patients with schizophrenia, but further study is needed to confirm the association between gluten and schizophrenia.<ref name="Kalaydjian_AE"> Kalaydjian AE, Eaton W, Cascella N, Fasano A (2006). The gluten connection: the association between schizophrenia and celiac disease. ''[[Acta Psychiatrica Scandinavica]]'' 2006 Feb;113(2):82–90. PMID 16423158</ref> | ||
An unconventional approach is the use of omega-3 fatty acids, with one study finding some benefits from their use as a dietary supplement.<ref>Peet M, Stokes C (2005). Omega-3 fatty acids in the treatment of psychiatric disorders. Drugs, 65(8), 1051–9. PMID 15907142</ref> | An unconventional approach is the use of omega-3 fatty acids, with one study finding some benefits from their use as a dietary supplement.<ref>Peet M, Stokes C (2005). Omega-3 fatty acids in the treatment of psychiatric disorders. Drugs, 65(8), 1051–9. PMID 15907142</ref> | ||
===LY2109823=== | |||
A new [[schizophrenia]] [[drug]] "''LY219873''" yielded promising results, as it targets in the [[brain]] – [[glutamate]] receptors rather than [[dopamine]] and had few side effects. The [[Nature Medicine]] study, by drug firm [[Eli Lilly]] found it promising and Dr.Sandeep Patil's team proved that LY2140023 appear to work as [[antipsychotics]] when tested upon [[rodents]].<ref>[http://news.bbc.co.uk/2/hi/health/6971037.stm BBC NEWS, Schizophrenia trials 'promising']</ref> | |||
===Nicotine Patch=== | |||
Following an observation that [[tobacco smoking]] eases effects of [[schizophrenia]], Dr. Tony George from the [[Yale School of Medicine]] proposed [[nicotine patch]] as a treatment for schizophrenia.<ref name=tonygeorge>[http://www.abc.net.au/rn/healthreport/stories/2002/614060.htm Smoking and schizophrenia]</ref> | |||
==References== | ==References== | ||
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Future or Investigational Therapies
Service-user led movements have become integral to the recovery process in Europe and America; groups such as the Hearing Voices Network and the Paranoia Network have developed a self-help approach that aims to provide support and assistance outside the traditional medical model adopted by mainstream psychiatry. By avoiding framing personal experience in terms of criteria for mental illness or mental health, they aim to destigmatize the experience and encourage individual responsibility and a positive self-image. Partnerships between hospitals and consumer-run groups are becoming more common, with services working toward remediating social withdrawal, building social skills and reducing rehospitalization.[1]
The Soteria Model
The Soteria model is an alternative treatment to institutionalization and early use of antipsychotics.[2] It is described as a milieu-therapeutic recovery method, characterized by its founder as "the 24 hour a day application of interpersonal phenomenologic interventions by a nonprofessional staff, usually without neuroleptic drug treatment, in the context of a small, homelike, quiet, supportive, protective, and tolerant social environment."[3] Soteria or Soteria-based houses are currently run in Sweden,[4] Germany,[5][6][7] Switzerland,[8] and Hungary.[9] The Soteria house in Berne, Switzerland is associated with a psychiatrist who teaches at the University of Berne, and has been featured in the Schweizerische Aertzezeitung, the Bulletin of Swiss Physicians.[10]
Orthomolecular Psychiatry
The biologically based branch of alternative medicine that deals with schizophrenia is known as orthomolecular psychiatry. Some scientists claim that schizophrenia can be treated effectively with nutrients like niacin, vitamin C and B6, omega-3 EFAs (fish oil) along with various minerals and amino acids.[11][12] The body's adverse reactions to gluten and other allergens are implicated in some alternative theories as the cause of some cases. This theory—discussed by one author in three British journals in the 1970s[13]—is unproven. A 2006 literature review suggests that gluten may be a factor for a subset of patients with schizophrenia, but further study is needed to confirm the association between gluten and schizophrenia.[14]
An unconventional approach is the use of omega-3 fatty acids, with one study finding some benefits from their use as a dietary supplement.[15]
LY2109823
A new schizophrenia drug "LY219873" yielded promising results, as it targets in the brain – glutamate receptors rather than dopamine and had few side effects. The Nature Medicine study, by drug firm Eli Lilly found it promising and Dr.Sandeep Patil's team proved that LY2140023 appear to work as antipsychotics when tested upon rodents.[16]
Nicotine Patch
Following an observation that tobacco smoking eases effects of schizophrenia, Dr. Tony George from the Yale School of Medicine proposed nicotine patch as a treatment for schizophrenia.[17]
References
- ↑ Goering P, Durbin J, Sheldon CT, Ochocka J, Nelson G, Krupa T. Who uses consumer-run self-help organizations? American Journal of Orthopsychiatry, 76 (3), 367-73. PMID 16981815
- ↑ Bola JR, Mosher LR (April 2003). "Treatment of Acute Psychosis Without Neuroleptics: Two-Year Outcomes From the Soteria Project" (PDF). The Journal of Nervous and Mental Disease. Lippincott Williams & Wilkins, Inc. 191: 219–229. PMID 12695732. Retrieved 2007-06-13.
- ↑ Mosher LR (1999). "Soteria and Other Alternatives to Acute Psychiatric Hospitalization: A Personal and Professional Review." Journal of Nervous and Mental Disease, 187, 142–149.
- ↑ Perris, C.M. Cognitive Therapy with Schizophrenic Patients. Guilford, New York, NY, 1989.
- ↑ Allgemeine Psychiatrie I / Soteria
- ↑ Toll - Haus
- ↑ Soteria
- ↑ Soteria Bern
- ↑ Soteria Alapítvány
- ↑ http://www.soteria.ch/pdf/Soteria%20Bern%20SAEZ.pdf Soteria
- ↑ Hoffer and Walker, Orthomolecular Nutrition. Keats Publishing, 1978
- ↑ Abram Hoffer (1999) Orthomolecular treatment for Schizophrenia, McGraw-Hill, ISBN 0879839104
- ↑ Dohan FC (1970). Coeliac disease and schizophrenia. Lancet, 1970 April 25;1(7652):897–8. PMID 4191543
*Dohan FC (1973). Coeliac disease and schizophrenia. British Medical Journal, 3(5870): 51–52. PMID 4740433
* Dohan FC (1979). Celiac-type diets in schizophrenia. Am J Psychiatry, 1979 May;136(5):732–3. PMID 434265 - ↑ Kalaydjian AE, Eaton W, Cascella N, Fasano A (2006). The gluten connection: the association between schizophrenia and celiac disease. Acta Psychiatrica Scandinavica 2006 Feb;113(2):82–90. PMID 16423158
- ↑ Peet M, Stokes C (2005). Omega-3 fatty acids in the treatment of psychiatric disorders. Drugs, 65(8), 1051–9. PMID 15907142
- ↑ BBC NEWS, Schizophrenia trials 'promising'
- ↑ Smoking and schizophrenia