Torsade de pointes: Difference between revisions

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==Differential diagnosis==
* [[Ventricular Tachycardia]] (polymorphic, monomorphic)
* [[Supraventricular tachycardia]]
* [[Ventricular Fibrillation]]
* [[Sudden Cardiac Death]]
* [[Syncope]]
* [[Renal Failure]]
* Dialysis complication
* Drug toxicity like [[antiarrhythmic]], [[Antihistaminics]]


==Electrocardiography==
==Electrocardiography==

Revision as of 01:44, 15 October 2012

Torsade de pointes
DiseasesDB 29252
MeSH D016171

Torsades de pointes Microchapters

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-In-Chief: Cafer Zorkun, M.D., Ph.D. [2]


Electrocardiography

EKG is the main diagnostic tool in patients with Torsade de pointes. EKG findings that can be seen are:

  • Progressive change in polarity of QRS about the isoelectric line occurs
  • Prolonged QT interval (QT ≥ 0.60 s or QTc ≥ 0.45 s)
  • Pathological U
  • Rotation of the heart's electrical axis by at least 180º
  • Preceded by short long and short RR-intervals
  • Triggered by an early premature ventricular contraction(R-on-T PVC)
  • Paroxysms of 5-20 beats at a rate ≥ 200 bpm
  • Patients may revert spontaneously to a nonpolymorphic ventricular tachycardia or ventricular fibrillation

Background

  1. The peaks of the QRS complexes appear to twist around the isoelectric axis.
  2. Polymorphic VT is distinguished from Torsades by the absence of QT prolongation in polymorphic VT.

EKG Findings

  1. Paroxysms of VT with irregular RR intervals.
  2. A ventricular rate between 200 and 250 beats per minute.
  3. Two or more cycles of QRS complexes with alternating polarity.
  4. Changing amplitude of the QRS complexes in each cycle in a sinusoidal fashion.
  5. Prolongation of the QT interval.
  6. Is often initiated by a PVC with a long coupling interval, R on T phenomenon.
  7. There are usually 5 to 20 complexes in each cycle.

Clinical Correlation

  1. Drugs: quinidine, PCA, norpace, amiodarone, phenothiazines, Tricyclic antidepressants, pentamidine.
    • with quinidine majority of the cases occur within one week of initiation, and with therapeutic levels
  2. Electrolyte imbalances: Hypokalemia, hypomagnesemia, hypocalcemia
  3. CAD
  4. MVP
  5. Variant angina
  6. Myocarditis
  7. Subarachnoid hemorrhage
  8. Congenital QT prolongation
  9. Liquid protein diets
  10. Hypothyroidism
    • because of bradycardia and a prolonged QT syndrome
  11. Organophosphate poisoning [1] [2]

Video: Torsade de pointes

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Torsade de pointes is characterized by constantly changing rhythm amplitude. 'Torsade de pointes' in French means "Twisting of the Points". The changing rhythm amplitudes comes from the ventricular depolarizing waves constantly shifting its axis. It is usually caused by hypomagnesemia, hypokalemia, and malnourished alcoholics. Although Torsades de Pointes (TdP) is a rare ventricular arrhythmia, it can degenerate into ventricular fibrillation, leading to death without rapid medical intervention. TdP is associated with long QT syndrome, a condition whereby prolonged QT intervals are visible on the ECG.

Other lab studies

Treatment

Acute Treatment

If the episode of does not terminate on its own and degenerates into ventricular fibrillation, cardioversion is required.

Lead II electrocardiogram showing Torsades being shocked by an Implantable cardioverter-defibrillator back to the patients baseline cardiac rhythm.

Once the patient is back in normal sinus rhythm, a vigorous search for and correction of conditions that predispose to torsades de pointes which include hypokalemia, hypomagnesemia, and bradycardia should be made. Magnesium sulfate (1-2 g IV over 30-60 seconds) reduces the influx of calcium thereby lowering the amplitude of early after depolarizations and should also be infused even if the magnesium is normal. [3][4] Administration of lidocaine is generally not effective, but mexiletene may be helpful in suppressing the recurrence of torsade de pointes.

Additional Information

Examples

EKG's shown below are courtesy of C. Michael Gibson MS MD, and copylefted


Examples from different resources

  • Arrhythmias in a patient with short coupled torsade de pointes[5]

    Arrhythmias in a patient with short coupled torsade de pointes[5]

  • Arrhythmias in a patient with short coupled torsades de pointes degenerating in ventricular fibrillation[5]

    Arrhythmias in a patient with short coupled torsades de pointes degenerating in ventricular fibrillation[5]


  • Arrhythmias in a patient with short coupled torsade de pointes: frequent short coupled extrasystoles[5]

    Arrhythmias in a patient with short coupled torsade de pointes: frequent short coupled extrasystoles[5]

  • Arrhythmias in a patient with short coupled torsade de pointes: frequent short coupled extrasystoles [5]

    Arrhythmias in a patient with short coupled torsade de pointes: frequent short coupled extrasystoles [5]


  • A 12 lead ECG recording example of TdP[6]

    A 12 lead ECG recording example of TdP[6]


Characteristic tracing showing the "twisting" (blue line) of Torsade de pointes

References

  1. ↑ Chou's Electrocardiography in Clinical Practice Third Edition, pp. 398-409.
  2. ↑ Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:194 ISBN 1591032016
  3. ↑ Hoshino K, Ogawa K, Hishitani T, Isobe T, Eto Y (2004). "Optimal administration dosage of magnesium sulfate for torsades de pointes in children with long QT syndrome". J Am Coll Nutr. 23 (5): 497S–500S. PMID 15466950. Unknown parameter |month= ignored (help)
  4. ↑ Hoshino K, Ogawa K, Hishitani T, Isobe T, Etoh Y (2006). "Successful uses of magnesium sulfate for torsades de pointes in children with long QT syndrome". Pediatr Int. 48 (2): 112–7. doi:10.1111/j.1442-200X.2006.02177.x. PMID 16635167. Unknown parameter |month= ignored (help)
  5. ↑ 5.0 5.1 5.2 5.3 Leenhardt A, Glaser E, Burguera M, Nuernberg M, Maison-Blanche P, and Coumel P. Short-coupled variant of torsade de pointes. A new electrocardiographic entity in the spectrum of idiopathic ventricular tachyarrhythmias. Circulation 1994 Jan; 89(1) 206-15. PMID 8281648
  6. ↑ Khan IA. Twelve-lead electrocardiogram of torsade de pointes Tex Heart Inst J. 2001; 28 (1): 69. PMID 11330748

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