Hepatitis D laboratory findings: Difference between revisions
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Revision as of 17:30, 4 December 2012
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Hepatitis D |
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Diagnosis |
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Treatment |
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Hepatitis D laboratory findings On the Web |
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American Roentgen Ray Society Images of Hepatitis D laboratory findings |
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Risk calculators and risk factors for Hepatitis D laboratory findings |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-In-Chief: Varun Kumar, M.B.B.S. [2]
Laboratory Findings
- Detection of HDV RNA using reverse transcriptase polymerase chain reaction assay has a high sensitivity in detection of HDV viremia.
- HDV antigen may be detected.
- Levels of anti-delta agent antibodies such as IgM and IgG are generally be elevated. Detection of IgA antibodies to HDV is exclusively associated with chronic HDV infection.[1]
- Patients may also be positive for HBsAg and anti-HB core IgM. However HBsAg levels may be suppressed to undetectable levels with active HDV replication.
- Liver function tests may generally show elevated serum alanine aminotransferase and aspartate aminotransferase levels.
- Elevated international normalized ratio (INR) with prolongation of prothrombin time suggests fulminant hepatic failure.
References
- ↑ McFarlane IG, Chaggar K, Davies SE, Smith HM, Alexander GJ, Williams R (1991). "IgA class antibodies to hepatitis delta virus antigen in acute and chronic hepatitis delta virus infections". Hepatology (Baltimore, Md.). 14 (6): 980–4. PMID 1959886. Unknown parameter
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