Atrial septal defect ostium primum overview

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

An ostium primum defect or endocardial cushion defect usually occurs due to the failure in fusion of the septum primum with the endocardial cushion. This defect is commonly associated with other cardiac anomalies in the septum such as ventricular septal defect, mitral valve cleft, pulmonary stenosis, subaortic stenosis, left superior vena cava, coarctation and atrioventricular septal defect. The abnormalities of the atrioventricular valves include the cleft mitral valve, and the single atrioventricular valve (a single large, deformed valve that flows into both the right ventricle and the left ventricle). It is often associated with Down's syndrome.