Hyperlipoproteinemia laboratory findings: Difference between revisions
Line 47: | Line 47: | ||
|} | |} | ||
===Other laboratory tests=== | === Other laboratory tests === | ||
For careful medical evaluation, must take into consideration all medications (both prescription and over-the-counter medications) and perform following tests to rule out secondary hyperlipidemias: | For careful medical evaluation, must take into consideration all medications (both prescription and over-the-counter medications) and perform following tests to rule out secondary hyperlipidemias: | ||
*Serum thyroid-stimulating hormone | |||
*Liver function tests | * Serum thyroid-stimulating hormone | ||
*Serum creatinine | * Liver function tests | ||
*Urinalysis | * Serum creatinine | ||
* Urinalysis | |||
Other tests that may be done include: | Other tests that may be done include: | ||
Studies of cells called fibroblasts to see how the body absorbs LDL cholesterol | Studies of cells called fibroblasts to see how the body absorbs LDL cholesterol | ||
Gene or receptor analysis for the defect associated with this condition | Gene or receptor analysis for the defect associated with this condition. | ||
=== Approach === | |||
{{familytree/start}} | |||
{{familytree | | | | | | | | | A01 | | | | | |A01=Hyperlipidemia}} | |||
{{familytree | | | | | | | | | |!| | | | | | ||}} | |||
{{familytree | | | | | | | | | |!| | | | | | ||}} | |||
{{familytree | | | | | | | | | B01 |-|-|B02|-|-| B03 |B01= Triglycerides > 75<sup>th</sup> Percentile|B02= NO|B03= Type IIa}} | |||
{{familytree | | | | | | | | | |!| | | | | | ||}} | |||
{{familytree | | | | | | | | | |!| | | | | | ||}} | |||
{{familytree | | | | | | | | | C01 | | | | | |C01= YES}} | |||
{{familytree | | | | | | | | | |!| | | | | | ||}} | |||
{{familytree | | | | | | | | | |!| | | | | | ||}} | |||
{{familytree | | | | | | | | | D01 | | | | | |D01=Types I, IIb, IV, V }} | |||
{{familytree | | | | | | | | | |!| | | | | | ||}} | |||
{{familytree | | | | | | | | | |!| | | | | | ||}} | |||
{{familytree | | | | | | | | | E01 |-|-|E02|-|-| E03 |E01= Total Cholesterol/Apo B ratio ≥ 6.2 |E02=NO|E03= Types IIb, IV }} | |||
{{familytree/end}} | |||
==References== | ==References== |
Revision as of 18:05, 24 October 2012
Lipoprotein Disorders Microchapters |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Laboratory Findings
Complete lipid profile
The US National Cholesterol Education Program Adult Treatment Panel III (NCEP ATP III) suggests screening asymptomatic individuals with a complete fasting lipid profile every 5 years. Obtain complete lipid profile after 9 to 12-hour fast. The reference values according to ATP III classification for making the diagnosis and risk stratification are depicted below:
Levels of total cholesterol (mg/dl) | |
< 200 | Desirable |
200 - 239 | Borderline high |
≥ 240 | High |
Levels of LDL cholesterol (mg/dl) | |
< 100 | Optimal |
100 - 129 | Near optimal |
130 - 159 | Borderline high |
160 - 189 | High |
≥ 190 | Very high |
Levels of HDL Cholesterol (mg/dl) | |
< 40 | Low |
≥ 60 | High |
Levels of serum triglycerides (mg/dl) | |
< 150 | Normal |
150 - 199 | Borderline high |
200 - 499 | High |
≥ 500 | Very high |
Other laboratory tests
For careful medical evaluation, must take into consideration all medications (both prescription and over-the-counter medications) and perform following tests to rule out secondary hyperlipidemias:
- Serum thyroid-stimulating hormone
- Liver function tests
- Serum creatinine
- Urinalysis
Other tests that may be done include: Studies of cells called fibroblasts to see how the body absorbs LDL cholesterol Gene or receptor analysis for the defect associated with this condition.
Approach
Hyperlipidemia | |||||||||||||||||||||||||||||||||||||||||
Triglycerides > 75th Percentile | NO | Type IIa | |||||||||||||||||||||||||||||||||||||||
YES | |||||||||||||||||||||||||||||||||||||||||
Types I, IIb, IV, V | |||||||||||||||||||||||||||||||||||||||||
Total Cholesterol/Apo B ratio ≥ 6.2 | NO | Types IIb, IV | |||||||||||||||||||||||||||||||||||||||