Hyperlipoproteinemia medical therapy

Lipoprotein Disorders Microchapters
Patient Information
Overview
Causes
Classification Hyperlipoproteinemia Hypolipoproteinemia
Treatment

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Hyperlipidemia requires early detection, careful evaluation and aggressive treatment with combination of therapeutic lifestyle changes and lipid-lowering drug therapies to reduce the risk of cardiovascular and cerebrovascular complications.

Medical Therapy

Medical Therapy in Children and Adolescents

1. Drug therapy
   • Statins
2. Adjuvant therapies

Pharmacotherapy

• Omega-3 fatty acids

Drug	Mechanisms of Benefit	Dosage	Advantages	Side Effects	Contraindications
Omega-3 fatty acids	↓ hepatic lipogenesis ↓ plasma lipoprotein lipase activity. ↑ hepatic mitochondrial and peroxisomal beta-oxidation Inhibition of acyl CoA:1,2-diacylglycerol acyltransferase enzyme EPAand DHA are poor enzyme substrates for triglyceride synthesis in liver & inhibits esterification of other fatty acids.	3 g/day of EPA and DHA is under FDA's "Generally Recognized As Safe" category. Higher doses increases risk of bleeding	↓ VLDL , ↓ serum triglyceride by ≥ 50%	Bleeding at high doses Fishy smell, Can be reduced by Freezing of medication Trying different formulation Taking medication with food Nausea (approximately 4 % of individuals at < 3 gm/d, and 20% at > 4gm/d experiences git side-effects)	Hypersensitivity