Hyperlipoproteinemia medical therapy

Lipoprotein Disorders Microchapters
Patient Information
Overview
Causes
Classification Hyperlipoproteinemia Hypolipoproteinemia
Treatment

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Hyperlipidemia requires early detection, careful evaluation and aggressive treatment with combination of therapeutic lifestyle changes and lipid-lowering drug therapies to reduce the risk of cardiovascular and cerebrovascular complications.

Medical Therapy

Medical Therapy in Children and Adolescents

1. Drug therapy
   • Statins
2. Adjuvant therapies

Omega-3 Fatty Acids

Drug	Mechanisms of Benefit	Dosage	Advantages	Side Effects	Contraindications
Omega-3 fatty acids	↓ hepatic lipogenesis ↓ plasma lipoprotein lipase activity ↑ hepatic mitochondrial and peroxisomal beta-oxidation Inhibition of acyl CoA:1,2-diacylglycerol acyltransferase enzyme EPA and DHA are poor enzyme substrates for triglyceride synthesis in liver and inhibits esterification of other fatty acids.	3 g/day of EPA and DHA	↓ VLDL, ↓ TG by ≥50%	Bleeding, at high doses Fishy smell, can be reduced by freezing of medication trying different formulation taking medication with food Nausea	Hypersensitivity

(↑ - Increase, ↓ - Decrease)