Donovanosis medical therapy: Difference between revisions
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one double-strength (160 mg/800 mg) tablet orally twice a day for at least 3 weeks and until all lesions have completely healed | one double-strength (160 mg/800 mg) tablet orally twice a day for at least 3 weeks and until all lesions have completely healed | ||
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Therapy should be continued at least 3 weeks and until all lesions have completely healed. Some specialists recommend the addition of an aminoglycoside (e.g., gentamicin 1 mg/kg IV every 8 hours) to these regimens if improvement is not evident within the first few days of therapy. | Therapy should be continued at least 3 weeks and until all lesions have completely healed. Some specialists recommend the addition of an aminoglycoside (e.g., gentamicin 1 mg/kg IV every 8 hours) to these regimens if improvement is not evident within the first few days of therapy. | ||
Revision as of 17:32, 30 November 2012
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Donovanosis Microchapters |
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Diagnosis |
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Treatment |
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Case Studies |
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Donovanosis medical therapy On the Web |
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American Roentgen Ray Society Images of Donovanosis medical therapy |
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Risk calculators and risk factors for Donovanosis medical therapy |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Kalsang Dolma, M.B.B.S.[2]
Overview
Medical Therapy
A limited number of studies on Donovanosis treatment have been published. Treatment halts progression of lesions, although prolonged therapy is usually required to permit granulation and reepithelialization of the ulcers. Healing typically proceeds inward from the ulcer margins. Relapse can occur 6–18 months after apparently effective therapy. Several antimicrobial regimens have been effective, but a limited number of controlled trials have been published.[1]
- Shown below is a table summarizing the preferred and alternative empiric treatment for Donovanosis.[2]
| Pathogens | Preferred Treatment | Duration of Treatment | Alternative Treatment |
| Klebsiella granulomatis | Doxycycline
100 mg orally twice a day |
For at least 3 weeks and until all lesions have completely healed | Azithromycin
1 g orally once per week for at least 3 weeks and until all lesions have completely healed OR Ciprofloxacin 750 mg orally twice a day for at least 3 weeks and until all lesions have completely healed OR Erythromycin base 500 mg orally four times a day for at least 3 weeks and until all lesions have completely healed OR Trimethoprim-sulfamethoxazole one double-strength (160 mg/800 mg) tablet orally twice a day for at least 3 weeks and until all lesions have completely healed |
Therapy should be continued at least 3 weeks and until all lesions have completely healed. Some specialists recommend the addition of an aminoglycoside (e.g., gentamicin 1 mg/kg IV every 8 hours) to these regimens if improvement is not evident within the first few days of therapy.
References
- ↑ O’Farrell N. Donovanosis. Sex Transmit Infect 2002;78:452–7.
- ↑ http://www.cdc.gov/std/treatment/2006/genital-ulcers.htm#genulc4