Granulocytosis: Difference between revisions
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==Overview== | ==Overview== | ||
Granulocytosis is defined as the presence of an increased number of [[granulocyte]]s, a category of [[white blood cell]]s present in the [[peripheral blood]]. Often, the word refers to an increased [[neutrophil granulocyte]] count, as '''''neutrophils are the main granulocytes'''''. An increase in [[eosinophil granulocyte]] is known as [[eosinophilia]]. In [[cardiovascular disease]], | Granulocytosis is defined as the presence of an increased number of [[granulocyte]]s, a category of [[white blood cell]]s present in the [[peripheral blood]]. Often, the word refers to an increased [[neutrophil granulocyte]] count, as '''''neutrophils are the main granulocytes'''''. An increase in [[eosinophil granulocyte]] is known as [[eosinophilia]]. In [[cardiovascular disease]], [[increased white blood cell counts]] have been shown to indicate a worse prognosis. | ||
==Common Causes== | ==Common Causes== | ||
Revision as of 12:05, 15 July 2013
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Lakshmi Gopalakrishnan, M.B.B.S. [2]
Overview
Granulocytosis is defined as the presence of an increased number of granulocytes, a category of white blood cells present in the peripheral blood. Often, the word refers to an increased neutrophil granulocyte count, as neutrophils are the main granulocytes. An increase in eosinophil granulocyte is known as eosinophilia. In cardiovascular disease, increased white blood cell counts have been shown to indicate a worse prognosis.
Common Causes
Granulocytosis can be a feature of a number of diseases:
- Infection, especially bacterial
- Malignancy, most notably leukemia (it is the main feature of chronic myelogenous leukemia, CML)
- Autoimmune disease
Causes by Organ System
Causes in Alphabetical Order
- Acute intermittent porphyria
- Acute myeloid leukemia
- Acute pancreatitis
- Acute promyelocytic leukemia
- Adult-onset Still's disease
- Aminophylline
- Bronchiolitis obliterans organizing pneumonia
- Chronic myeloid leukaemia
- Congenital syphilis
- Dinoprostone
- Extrinsic allergic alveolitis
- Filgrastim
- Gallbladder empyema
- Granulocyte colony stimulating factor
- Granulocyte-macrophage colony stimulating factor
- Hantavirus
- Hereditary neutrophilia
- Hyperimmunoglobulinemia D and periodic fever syndrome
- Leukocyte adhesion deficiency type 1
- Leukocyte adhesion deficiency type 2
- Leukocyte adhesion deficiency type 3
- Leukemoid reaction
- Lithium
- Lymphangitis
- Mast cell leukemia
- Polycythaemia rubra vera
- Recurrent hereditary polyserositis
- Severe acute respiratory syndrome
- Splenectomy
- Sulprostone
- Urate crystal arthropathy
- Wegener granulomatosis