Rift valley fever epidemiology and demographics: Difference between revisions
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RVF virus primarily affects livestock and can cause disease in a large number of domestic animals (this situation is referred to as an "epizootic"). The presence of an RVF epizootic can lead to an epidemic among humans who are exposed to diseased animals. The most notable epizootic of RVF, which occurred in Kenya in 1950-1951, resulted in the death of an estimated 100,000 sheep. In 1977, the virus was detected in Egypt (probably exported there in infected domestic animals from Sudan) and caused a large outbreak of RVF among animals and humans. The first epidemic of RVF in West Africa was reported in 1987 and was linked to construction of the Senegal River Project. The project caused flooding in the lower Senegal River area and altered interactions between animals and humans resulting in transmission of the RVF virus to humans. | RVF virus primarily affects livestock and can cause disease in a large number of domestic animals (this situation is referred to as an "epizootic"). The presence of an RVF epizootic can lead to an epidemic among humans who are exposed to diseased animals. The most notable epizootic of RVF, which occurred in Kenya in 1950-1951, resulted in the death of an estimated 100,000 sheep. In 1977, the virus was detected in Egypt (probably exported there in infected domestic animals from Sudan) and caused a large outbreak of RVF among animals and humans. The first epidemic of RVF in West Africa was reported in 1987 and was linked to construction of the Senegal River Project. The project caused flooding in the lower Senegal River area and altered interactions between animals and humans resulting in transmission of the RVF virus to humans. | ||
'''Rift Valley Fever Outbreak --- Kenya, November 2006--January 2007''' | |||
In mid-December 2006, several unexplained fatalities associated with fever and generalized bleeding were reported to the Kenya Ministry of Health (KMOH) from Garissa District in North Eastern Province (NEP). By December 20, a total of 11 deaths had been reported. Of serum samples collected from the first 19 patients, Rift Valley fever (RVF) virus RNA or immunoglobulin M (IgM) antibodies against RVF virus were found in samples from 10 patients; all serum specimens were negative for [[yellow fever]], [[Ebola]], Crimean-Congo hemorrhagic fever, and [[dengue]] viruses. The outbreak was confirmed by isolation of RVF virus from six of the specimens. Humans can be infected with RVF virus from bites of mosquitoes or other arthropod vectors that have fed on animals infected with RVF virus, or through contact with viremic animals, particularly livestock. Reports of livestock deaths and unexplained animal abortions in NEP provided further evidence of an RVF outbreak. On December 20, an investigation was launched by KMOH, the Kenya Field Epidemiology and Laboratory Training Program (FELTP), the Kenya Medical Research Institute (KEMRI), the Walter Reed Project of the U.S. Army Medical Research Unit, CDC-Kenya's Global Disease Detection Center, and other partners, including the World Health Organization (WHO) and Médecins Sans Frontières (MSF). This report describes the findings from that initial investigation and the control measures taken in response to the RVF outbreak, which spread to multiple additional provinces and districts, resulting in 404 cases with 118 deaths as of January 25, 2007. | |||
Teams of investigators conducted patient interviews and reviewed medical records from December 1 forward in major health-care facilities in the districts from which cases were first reported. The teams detected additional cases by meeting with elders, other leaders, and health-care providers in villages where cases had been reported and in adjacent villages. Blood samples from patients with suspected RVF were collected and maintained at 39.2ºF (4.0ºC). Samples from NEP and surrounding areas were transported to a field laboratory established at Garissa Provincial Hospital by CDC, KEMRI, and KMOH; samples from other areas were sent to KEMRI laboratories in Nairobi and to a laboratory in Malindi that was supported by a team from Health Canada. | |||
A suspected case was defined as acute onset of fever (>99.5ºF [>37.5ºC]) with [[headache]] or muscle and [[joint pain]] since December 1 in a person who had no other known cause of acute febrile illness (e.g., [[malaria]]). A probable case was defined as acute onset of [[fever]] in a person with unexplained [[bleeding]] (i.e., in stool, vomit, or sputum or from gums, nose, vagina, skin, or eyes), vision deterioration, or altered consciousness. A confirmed case was defined as a suspected or probable case with laboratory confirmation of the presence in serum of anti-RVF virus IgM by enzyme-linked immunosorbent assay ([[ELISA]]) or RVF virus RNA by reverse transcription--polymerase chain reaction ([[RT-PCR]]). | |||
The index case was reported in Garissa District in a patient who had symptom onset on November 30, 2006. Retrospective analysis of sera collected during July--November 2006 at Garissa Provincial Hospital revealed no evidence of earlier acute RVF infections. As of January 25, 2007, a total of 404 cases of RVF had been reported in Kenya with 118 deaths, a case-fatality rate of 29%. Of the reported cases, 115 (29%) were laboratory confirmed by anti-RVF virus IgM by ELISA (64 cases, 56%) or RT-PCR (79, 69%), including 28 cases (24%) confirmed by both. Of the remaining 289 cases, 109 were classified as probable. | |||
Of the 230 patients with available demographic information, 140 (61%) were male. Patients ranged in age from 4 to 85 years, with a median age of 27 years (30 years for females and 25 years for males). RVF cases were reported from three districts in NEP (Garissa [175 cases], Ijara [125], and Wajir [26]); five districts in Coast Province (Kilifi [38], Tana River [16], Malindi [eight], Isiolo [eight], and Taita Taveta [one]); two districts in Central Province (Kirinyanga [two] and Maragua [one]); one district in Rift Valley Province (Kajiado [three]); and one from Nairobi Area (Figure 2). The patient from Nairobi had traveled to NEP during the week before illness onset but was hospitalized in Nairobi. Ijara (population 79,932) and Garissa (population 420,918) districts had the highest RVF incidence rates: 156 and 42 per 100,000 population, respectively. | |||
Among the first 97 reported cases from Garissa and Wajir districts with detailed epidemiologic information available, 71 (73%) met the probable case definition; 38 of the 62 patients who provided blood samples tested positive by IgM ELISA, RT-PCR, or both. The most frequently reported symptoms among the 97 patients were [[fever]] (100%), [[headache]] (90%), [[bleeding]] (76%), [[malaise]] (70%), [[muscle pain]] (62%), back pain (60%), [[vomiting]] (56%), and [[joint pain]] (51%). | |||
Two thirds of the 66 patients who provided information on potential risk factors reported having an animal that was recently ill. The most frequently reported RVF risk factors during the 2 weeks preceding illness onset were drinking unboiled (raw) milk (72%); living within 100 meters of a swamp (70%); having an ill animal (67%); drinking milk from an ill animal (59%); working as a herdsman (50%); having a dead animal (50%); and slaughtering an animal (42%). Approximately 9% of patients reported contact with another ill human. | |||
The outbreak peaked on December 24, 2006, and the number of daily cases has been declining since December 27, 2006. A ban on livestock slaughtering in Garissa District went into effect on December 27 and was expanded as RVF was detected in additional districts. Vaccination of animals with live, attenuated RVF vaccine began on January 8, 2007. Prevention messages were developed in three languages (English, Kiswhali, and Somali), and public meetings (known as barazas) were held to spread information rapidly to the community. Messages also were disseminated via radio, a widely used communication medium in NEP. Village elders, chiefs, and religious leaders were consulted throughout Garissa District, leading to a district ban on the slaughter of livestock and closure of the livestock market. Health-care workers were trained to care for persons suspected to be infected with RVF virus. | |||
'''2000-2001: Rift Valley Fever Outbreak in Saudi Arabia and Yemen ''' | |||
In September 2000, the Ministry of Health of the Kingdom of Saudi Arabia, and subsequently the Ministry of Health of Yemen received reports of unexplained hemorrhagic fever in humans and associated animal deaths from the southwestern border of Saudi Arabia and Yemen. CDC confirmed the outbreak to be caused by Rift Valley fever virus. | |||
'''Rift Valley Fever -- East Africa, 1997-1998''' | |||
In December 1997, the Kenya Ministry of Health and the World Health Organization (WHO) in Nairobi received reports of 478 unexplained deaths in the North Eastern province of Kenya and southern Somalia. Clinical features included acute onset of fever and headache associated with [[hemorrhage]] (hematochezia, hematemesis, and bleeding from other mucosal sites). Local health officials also reported high rates of illness and death resulting from hemorrhage among domestic animals in the area. This report describes the preliminary results of the outbreak investigation and the results of a serologic survey. | |||
From late October 1997 through January 1998, torrential rains occurred in most of East Africa, resulting in the worst flooding in the region since 1961 and rainfall that was 60-100 times the seasonal average (National Climatic Data Center, unpublished data, 1998). Diagnostic testing of the initial 36 specimens received at the National Institute of Virology, South Africa, and at CDC confirmed acute infection with Rift Valley fever (RVF) virus in 17 (47%) persons from whom specimens were obtained; confirmation was made by detection of IgM antibodies, virus isolation, reverse-transcriptase-polymerase chain reaction for viral nucleic acid, or immunohistochemistry. | |||
Active surveillance conducted by WHO, the Kenya Ministry of Health, and international relief organizations during December 22-28 in 18 villages (population: 200,000) in Garissa district, North Eastern province, Kenya, identified 170 deaths resulting from a "bleeding disease." Severe flooding and large distances between settlements complicated case ascertainment and subsequent evaluation. Despite these constraints, the surveillance system received reports and blood specimens for 231 cases of unexplained severe febrile illness with onset from November 25, 1997, through February 14, 1998. Of the 231 reported cases, 115 met the case definition for hemorrhagic fever (i.e., [[fever]] and mucosal or gastrointestinal [[bleeding]]). Of the 115 patients with [[hemorrhagic fever]], 58% were male (median age: 30 years {range: 3-85 years}); diagnostic testing demonstrated acute RVF viral infection in 27 (23%) (Figure_1). Of the 116 persons whose illnesses did not meet the case-definition for hemorrhagic fever, 26 (22%) had acute infection with RVF virus. Of these 26 persons, 14 had symptoms compatible with complications of RVF viral infection, including nine with neurologic disease and five with visual disturbances. In addition to the confirmed RVF cases in the North Eastern province and the Gedo, Hiran, and Lower Shabeelle provinces of Somalia, acute confirmed RVF cases were identified in the Central (one case), Eastern (nine cases), and Rift Valley (12 cases) provinces of Kenya (Figure_2). | |||
Studies conducted during this outbreak included human, livestock, and entomologic sampling. Using a multistage cluster sampling strategy based on the population distribution in Garissa district, an international task force led by the Kenya Ministry of Health conducted a cross-sectional study to examine risk factors and determine the prevalence of recent infection with RVF virus. Anti-RVF virus IgM was detected by enzyme-linked immunosorbent assay in 18 (9%) of the 202 persons in the sample; all 18 had recently been ill, compared with 80% of the seronegative persons (p=0.05). The study did not identify statistically significant differences in the frequency of IgM antibody by sex or age. However, contact with livestock (e.g., herding, milking, slaughtering, and sheltering animals in the home) was statistically associated with serologic evidence of acute infection with RVF virus (p less than 0.01). | |||
In this cross-sectional survey, livestock owners reported losses of approximately 70% of their sheep and goats and 20%-30% of cattle and camels. Other infections contributing to the high mortality in the epizootic included nonspecific [[pneumonia]], pasteurellosis, contagious caprine pleuropneumonia, contagious pustular dermatitis, bluetongue, and complications of mange and foot rot (Field Mission of the Food and Agriculture Organization of the United Nations, unpublished data, 1998). RVF serologic results from animal samples collected by veterinary staff in this and other regions of Kenya are pending. | |||
In February 1998 in Garissa district, 3180 mosquitoes from three trapping sites were collected. Three of the nine captured species have been previously implicated in RVF transmission (Anopheles coustani, Mansonia africana, and M. uniformis). Viral isolation studies are under way. | |||
==References== | ==References== | ||
Revision as of 21:39, 5 December 2012
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Epidemiology and Demographics
Where is the disease found?
RVF is generally found in regions of eastern and southern Africa where sheep and cattle are raised, but the virus also exists in most countries of sub-Saharan Africa and in Madagascar. In September 2000, a RVF outbreak was reported in Saudi Arabia and subsequently Yemen. These cases represent the first Rift Valley fever cases identified outside Africa.
RVF virus primarily affects livestock and can cause disease in a large number of domestic animals (this situation is referred to as an "epizootic"). The presence of an RVF epizootic can lead to an epidemic among humans who are exposed to diseased animals. The most notable epizootic of RVF, which occurred in Kenya in 1950-1951, resulted in the death of an estimated 100,000 sheep. In 1977, the virus was detected in Egypt (probably exported there in infected domestic animals from Sudan) and caused a large outbreak of RVF among animals and humans. The first epidemic of RVF in West Africa was reported in 1987 and was linked to construction of the Senegal River Project. The project caused flooding in the lower Senegal River area and altered interactions between animals and humans resulting in transmission of the RVF virus to humans.
Rift Valley Fever Outbreak --- Kenya, November 2006--January 2007
In mid-December 2006, several unexplained fatalities associated with fever and generalized bleeding were reported to the Kenya Ministry of Health (KMOH) from Garissa District in North Eastern Province (NEP). By December 20, a total of 11 deaths had been reported. Of serum samples collected from the first 19 patients, Rift Valley fever (RVF) virus RNA or immunoglobulin M (IgM) antibodies against RVF virus were found in samples from 10 patients; all serum specimens were negative for yellow fever, Ebola, Crimean-Congo hemorrhagic fever, and dengue viruses. The outbreak was confirmed by isolation of RVF virus from six of the specimens. Humans can be infected with RVF virus from bites of mosquitoes or other arthropod vectors that have fed on animals infected with RVF virus, or through contact with viremic animals, particularly livestock. Reports of livestock deaths and unexplained animal abortions in NEP provided further evidence of an RVF outbreak. On December 20, an investigation was launched by KMOH, the Kenya Field Epidemiology and Laboratory Training Program (FELTP), the Kenya Medical Research Institute (KEMRI), the Walter Reed Project of the U.S. Army Medical Research Unit, CDC-Kenya's Global Disease Detection Center, and other partners, including the World Health Organization (WHO) and Médecins Sans Frontières (MSF). This report describes the findings from that initial investigation and the control measures taken in response to the RVF outbreak, which spread to multiple additional provinces and districts, resulting in 404 cases with 118 deaths as of January 25, 2007.
Teams of investigators conducted patient interviews and reviewed medical records from December 1 forward in major health-care facilities in the districts from which cases were first reported. The teams detected additional cases by meeting with elders, other leaders, and health-care providers in villages where cases had been reported and in adjacent villages. Blood samples from patients with suspected RVF were collected and maintained at 39.2ºF (4.0ºC). Samples from NEP and surrounding areas were transported to a field laboratory established at Garissa Provincial Hospital by CDC, KEMRI, and KMOH; samples from other areas were sent to KEMRI laboratories in Nairobi and to a laboratory in Malindi that was supported by a team from Health Canada.
A suspected case was defined as acute onset of fever (>99.5ºF [>37.5ºC]) with headache or muscle and joint pain since December 1 in a person who had no other known cause of acute febrile illness (e.g., malaria). A probable case was defined as acute onset of fever in a person with unexplained bleeding (i.e., in stool, vomit, or sputum or from gums, nose, vagina, skin, or eyes), vision deterioration, or altered consciousness. A confirmed case was defined as a suspected or probable case with laboratory confirmation of the presence in serum of anti-RVF virus IgM by enzyme-linked immunosorbent assay (ELISA) or RVF virus RNA by reverse transcription--polymerase chain reaction (RT-PCR).
The index case was reported in Garissa District in a patient who had symptom onset on November 30, 2006. Retrospective analysis of sera collected during July--November 2006 at Garissa Provincial Hospital revealed no evidence of earlier acute RVF infections. As of January 25, 2007, a total of 404 cases of RVF had been reported in Kenya with 118 deaths, a case-fatality rate of 29%. Of the reported cases, 115 (29%) were laboratory confirmed by anti-RVF virus IgM by ELISA (64 cases, 56%) or RT-PCR (79, 69%), including 28 cases (24%) confirmed by both. Of the remaining 289 cases, 109 were classified as probable.
Of the 230 patients with available demographic information, 140 (61%) were male. Patients ranged in age from 4 to 85 years, with a median age of 27 years (30 years for females and 25 years for males). RVF cases were reported from three districts in NEP (Garissa [175 cases], Ijara [125], and Wajir [26]); five districts in Coast Province (Kilifi [38], Tana River [16], Malindi [eight], Isiolo [eight], and Taita Taveta [one]); two districts in Central Province (Kirinyanga [two] and Maragua [one]); one district in Rift Valley Province (Kajiado [three]); and one from Nairobi Area (Figure 2). The patient from Nairobi had traveled to NEP during the week before illness onset but was hospitalized in Nairobi. Ijara (population 79,932) and Garissa (population 420,918) districts had the highest RVF incidence rates: 156 and 42 per 100,000 population, respectively.
Among the first 97 reported cases from Garissa and Wajir districts with detailed epidemiologic information available, 71 (73%) met the probable case definition; 38 of the 62 patients who provided blood samples tested positive by IgM ELISA, RT-PCR, or both. The most frequently reported symptoms among the 97 patients were fever (100%), headache (90%), bleeding (76%), malaise (70%), muscle pain (62%), back pain (60%), vomiting (56%), and joint pain (51%).
Two thirds of the 66 patients who provided information on potential risk factors reported having an animal that was recently ill. The most frequently reported RVF risk factors during the 2 weeks preceding illness onset were drinking unboiled (raw) milk (72%); living within 100 meters of a swamp (70%); having an ill animal (67%); drinking milk from an ill animal (59%); working as a herdsman (50%); having a dead animal (50%); and slaughtering an animal (42%). Approximately 9% of patients reported contact with another ill human.
The outbreak peaked on December 24, 2006, and the number of daily cases has been declining since December 27, 2006. A ban on livestock slaughtering in Garissa District went into effect on December 27 and was expanded as RVF was detected in additional districts. Vaccination of animals with live, attenuated RVF vaccine began on January 8, 2007. Prevention messages were developed in three languages (English, Kiswhali, and Somali), and public meetings (known as barazas) were held to spread information rapidly to the community. Messages also were disseminated via radio, a widely used communication medium in NEP. Village elders, chiefs, and religious leaders were consulted throughout Garissa District, leading to a district ban on the slaughter of livestock and closure of the livestock market. Health-care workers were trained to care for persons suspected to be infected with RVF virus.
2000-2001: Rift Valley Fever Outbreak in Saudi Arabia and Yemen
In September 2000, the Ministry of Health of the Kingdom of Saudi Arabia, and subsequently the Ministry of Health of Yemen received reports of unexplained hemorrhagic fever in humans and associated animal deaths from the southwestern border of Saudi Arabia and Yemen. CDC confirmed the outbreak to be caused by Rift Valley fever virus.
Rift Valley Fever -- East Africa, 1997-1998
In December 1997, the Kenya Ministry of Health and the World Health Organization (WHO) in Nairobi received reports of 478 unexplained deaths in the North Eastern province of Kenya and southern Somalia. Clinical features included acute onset of fever and headache associated with hemorrhage (hematochezia, hematemesis, and bleeding from other mucosal sites). Local health officials also reported high rates of illness and death resulting from hemorrhage among domestic animals in the area. This report describes the preliminary results of the outbreak investigation and the results of a serologic survey.
From late October 1997 through January 1998, torrential rains occurred in most of East Africa, resulting in the worst flooding in the region since 1961 and rainfall that was 60-100 times the seasonal average (National Climatic Data Center, unpublished data, 1998). Diagnostic testing of the initial 36 specimens received at the National Institute of Virology, South Africa, and at CDC confirmed acute infection with Rift Valley fever (RVF) virus in 17 (47%) persons from whom specimens were obtained; confirmation was made by detection of IgM antibodies, virus isolation, reverse-transcriptase-polymerase chain reaction for viral nucleic acid, or immunohistochemistry.
Active surveillance conducted by WHO, the Kenya Ministry of Health, and international relief organizations during December 22-28 in 18 villages (population: 200,000) in Garissa district, North Eastern province, Kenya, identified 170 deaths resulting from a "bleeding disease." Severe flooding and large distances between settlements complicated case ascertainment and subsequent evaluation. Despite these constraints, the surveillance system received reports and blood specimens for 231 cases of unexplained severe febrile illness with onset from November 25, 1997, through February 14, 1998. Of the 231 reported cases, 115 met the case definition for hemorrhagic fever (i.e., fever and mucosal or gastrointestinal bleeding). Of the 115 patients with hemorrhagic fever, 58% were male (median age: 30 years {range: 3-85 years}); diagnostic testing demonstrated acute RVF viral infection in 27 (23%) (Figure_1). Of the 116 persons whose illnesses did not meet the case-definition for hemorrhagic fever, 26 (22%) had acute infection with RVF virus. Of these 26 persons, 14 had symptoms compatible with complications of RVF viral infection, including nine with neurologic disease and five with visual disturbances. In addition to the confirmed RVF cases in the North Eastern province and the Gedo, Hiran, and Lower Shabeelle provinces of Somalia, acute confirmed RVF cases were identified in the Central (one case), Eastern (nine cases), and Rift Valley (12 cases) provinces of Kenya (Figure_2).
Studies conducted during this outbreak included human, livestock, and entomologic sampling. Using a multistage cluster sampling strategy based on the population distribution in Garissa district, an international task force led by the Kenya Ministry of Health conducted a cross-sectional study to examine risk factors and determine the prevalence of recent infection with RVF virus. Anti-RVF virus IgM was detected by enzyme-linked immunosorbent assay in 18 (9%) of the 202 persons in the sample; all 18 had recently been ill, compared with 80% of the seronegative persons (p=0.05). The study did not identify statistically significant differences in the frequency of IgM antibody by sex or age. However, contact with livestock (e.g., herding, milking, slaughtering, and sheltering animals in the home) was statistically associated with serologic evidence of acute infection with RVF virus (p less than 0.01).
In this cross-sectional survey, livestock owners reported losses of approximately 70% of their sheep and goats and 20%-30% of cattle and camels. Other infections contributing to the high mortality in the epizootic included nonspecific pneumonia, pasteurellosis, contagious caprine pleuropneumonia, contagious pustular dermatitis, bluetongue, and complications of mange and foot rot (Field Mission of the Food and Agriculture Organization of the United Nations, unpublished data, 1998). RVF serologic results from animal samples collected by veterinary staff in this and other regions of Kenya are pending.
In February 1998 in Garissa district, 3180 mosquitoes from three trapping sites were collected. Three of the nine captured species have been previously implicated in RVF transmission (Anopheles coustani, Mansonia africana, and M. uniformis). Viral isolation studies are under way.