Hookworm infection pathophysiology: Difference between revisions
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Eggs are passed in the stool '''1''', and under favorable conditions (moisture, warmth, shade), larvae hatch in 1 to 2 days. The released rhabditiform larvae grow in the feces and/or the soil '''2''', and after 5 to 10 days (and two molts) they become become filariform (third-stage) larvae that are infective '''3'''. These infective larvae can survive 3 to 4 weeks in favorable environmental conditions. On contact with the human host, the larvae penetrate the skin and are carried through the veins to the heart and then to the lungs. They penetrate into the pulmonary alveoli, ascend the bronchial tree to the pharynx, and are swallowed '''4'''. The larvae reach the small intestine, where they reside and mature into adults. Adult worms live in the lumen of the small intestine, where they attach to the intestinal wall with resultant blood loss by the host '''5'''. Most adult worms are eliminated in 1 to 2 years, but longevity records can reach several years. | Eggs are passed in the stool '''(1)''', and under favorable conditions (moisture, warmth, shade), larvae hatch in 1 to 2 days. The released rhabditiform larvae grow in the feces and/or the soil '''(2)''', and after 5 to 10 days (and two molts) they become become filariform (third-stage) larvae that are infective '''(3)'''. These infective larvae can survive 3 to 4 weeks in favorable environmental conditions. On contact with the human host, the larvae penetrate the skin and are carried through the veins to the heart and then to the lungs. They penetrate into the pulmonary alveoli, ascend the bronchial tree to the pharynx, and are swallowed '''(4)'''. The larvae reach the small intestine, where they reside and mature into adults. Adult worms live in the lumen of the small intestine, where they attach to the intestinal wall with resultant blood loss by the host '''(5)'''. Most adult worms are eliminated in 1 to 2 years, but longevity records can reach several years. | ||
Some A. duodenale larvae, following penetration of the host skin, can become dormant (in the intestine or muscle). In addition, infection by A. duodenale may probably also occur by the oral and transmammary route. N. americanus, however, requires a transpulmonary migration phase. | Some A. duodenale larvae, following penetration of the host skin, can become dormant (in the intestine or muscle). In addition, infection by A. duodenale may probably also occur by the oral and transmammary route. N. americanus, however, requires a transpulmonary migration phase. | ||
Revision as of 15:31, 7 December 2012
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Pathophysiology
Etiologic Agents
The human hookworms include two nematode (roundworm) species, Ancylostoma duodenale and Necator americanus. (Adult females: 10 to 13 mm (A. duodenale), 9 to 11 mm (N. americanus); adult males: 8 to 11 mm (A. duodenale), 7 to 9 mm (N. americanus). A smaller group of hookworms infecting animals can invade and parasitize humans (A. ceylanicum) or can penetrate the human skin (causing cutaneous larva migrans), but do not develop any further (A. braziliense, A. caninum, Uncinaria stenocephala). Occasionally A. caninum larva may migrate to the human intestine causing eosinophilic enteritis; this may happen when larva is ingested rather than through skin invasion.
Life Cycle
Eggs are passed in the stool (1), and under favorable conditions (moisture, warmth, shade), larvae hatch in 1 to 2 days. The released rhabditiform larvae grow in the feces and/or the soil (2), and after 5 to 10 days (and two molts) they become become filariform (third-stage) larvae that are infective (3). These infective larvae can survive 3 to 4 weeks in favorable environmental conditions. On contact with the human host, the larvae penetrate the skin and are carried through the veins to the heart and then to the lungs. They penetrate into the pulmonary alveoli, ascend the bronchial tree to the pharynx, and are swallowed (4). The larvae reach the small intestine, where they reside and mature into adults. Adult worms live in the lumen of the small intestine, where they attach to the intestinal wall with resultant blood loss by the host (5). Most adult worms are eliminated in 1 to 2 years, but longevity records can reach several years. Some A. duodenale larvae, following penetration of the host skin, can become dormant (in the intestine or muscle). In addition, infection by A. duodenale may probably also occur by the oral and transmammary route. N. americanus, however, requires a transpulmonary migration phase.
Can Animals Transmit Hookworm Infection to Me?
Yes, but not directly. Puppies and kittens are especially likely to have hookworm infections. Animals that are infected pass hookworm eggs in their stools. The eggs can hatch into larvae, and both eggs and larvae may be found in dirt where animals have been. Eggs or larvae can get into your body when you accidentally eat or have direct contact with contaminated dirt. For example, this can happen if a child is walking barefoot or playing in an area where dogs or cats have been (especially puppies or kittens).