Chikungunya laboratory findings: Difference between revisions
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==Laboratory Findings== | ==Laboratory Findings== | ||
* | * Clinical laboratory findings can include lymphopenia, thrombocytopenia, elevated creatinine, and elevated hepatic transaminases. | ||
* Laboratory diagnosis is generally accomplished by testing serum or plasma to detect virus, viral nucleic acid, or virus-specific immunoglobulin (Ig) M and neutralizing antibodies. | |||
* | * Viral culture may detect virus in the first 3 days of illness; however, chikungunya virus should be handled under biosafety level (BSL) 3 conditions. | ||
* During the first 8 days of illness, chikungunya viral RNA can often be identified in serum. | |||
* | * Chikungunya virus antibodies normally develop toward the end of the first week of illness. Therefore, to definitively rule out the diagnosis, convalescent-phase samples should be obtained from patients whose acute-phase samples test negative. | ||
* Chikungunya virus testing is performed at CDC, a few state health departments, and one commercial laboratory. | |||
* Test results are normally available 4 to 14 days after specimen receipt. | |||
* Reporting times for test results may be longer during summer months when arbovirus activity increases. | |||
* Receipt of a hard copy of the results will take at least 2 weeks after testing is completed. | |||
* Initial serological testing will be performed using IgM-capture ELISA and IgG ELISA. If the initial results are positive, further confirmatory testing will be performed and it may delay the reporting of final results. | |||
==References== | ==References== | ||
Revision as of 19:06, 5 June 2014
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Laboratory Findings
- Clinical laboratory findings can include lymphopenia, thrombocytopenia, elevated creatinine, and elevated hepatic transaminases.
- Laboratory diagnosis is generally accomplished by testing serum or plasma to detect virus, viral nucleic acid, or virus-specific immunoglobulin (Ig) M and neutralizing antibodies.
- Viral culture may detect virus in the first 3 days of illness; however, chikungunya virus should be handled under biosafety level (BSL) 3 conditions.
- During the first 8 days of illness, chikungunya viral RNA can often be identified in serum.
- Chikungunya virus antibodies normally develop toward the end of the first week of illness. Therefore, to definitively rule out the diagnosis, convalescent-phase samples should be obtained from patients whose acute-phase samples test negative.
- Chikungunya virus testing is performed at CDC, a few state health departments, and one commercial laboratory.
- Test results are normally available 4 to 14 days after specimen receipt.
- Reporting times for test results may be longer during summer months when arbovirus activity increases.
- Receipt of a hard copy of the results will take at least 2 weeks after testing is completed.
- Initial serological testing will be performed using IgM-capture ELISA and IgG ELISA. If the initial results are positive, further confirmatory testing will be performed and it may delay the reporting of final results.