Tropical spastic paraparesis history and symptoms: Difference between revisions
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==History and Symptoms== | ==History and Symptoms== | ||
Patients with HAM/TSP may exhibit [[uveitis]] (inflammation of the uveal tract of the eye), [[arthritis]] (inflammation of one or more joints), [[alveolitis|pulmonary lymphocytic alveolitis]] (inflammation of the lung tissues), [[polymyositis]] (an inflammatory muscle disease), [[keratoconjunctivitis sicca]] (persistent dryness of the cornea and conjunctiva), and [[dermatitis|infectious dermatitis]] (inflammation of the skin). Co-factors that may play a role in transmitting the disorder include being a recipient of transfusion blood products (especially before 1989), [[breast feeding|breastmilk feeding]] from a [[seropositive]] mother, [[intravenous drug]] use, or being the sexual partner of a seropositive individual for several years. Not every HTLV-1 seropositive carrier will become a HAM/TSP patient. Fewer than 5% will exhibit neurological dysfunction or, eventually, hematological malignancy such as [[adult T-cell leukemia]]/lymphoma, suggesting that other host or viral factors are responsible for disease onset. | |||
==References== | ==References== | ||
Revision as of 00:42, 11 December 2012
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Tropical spastic paraparesis Microchapters |
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
History and Symptoms
Patients with HAM/TSP may exhibit uveitis (inflammation of the uveal tract of the eye), arthritis (inflammation of one or more joints), pulmonary lymphocytic alveolitis (inflammation of the lung tissues), polymyositis (an inflammatory muscle disease), keratoconjunctivitis sicca (persistent dryness of the cornea and conjunctiva), and infectious dermatitis (inflammation of the skin). Co-factors that may play a role in transmitting the disorder include being a recipient of transfusion blood products (especially before 1989), breastmilk feeding from a seropositive mother, intravenous drug use, or being the sexual partner of a seropositive individual for several years. Not every HTLV-1 seropositive carrier will become a HAM/TSP patient. Fewer than 5% will exhibit neurological dysfunction or, eventually, hematological malignancy such as adult T-cell leukemia/lymphoma, suggesting that other host or viral factors are responsible for disease onset.