Lymphogranuloma venereum pathophysiology: Difference between revisions

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{{Lymphogranuloma venereum}}
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==Overview==


==Pathophysiology==
==Pathophysiology==
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===Transmission===
===Transmission===
LGV is passed from person to person through direct contact with lesions, [[ulcer]]s or other area where the bacteria is located. Transmission of the organism occurs during sexual penetration (vaginal, oral, or anal) and may also occur via skin to skin contact. The likelihood of LGV infection following an exposure is unknown, but it is considered less infectious than some other STDs. A person who has had sexual contact with a LGV-infected partner within 60 days of symptom onset should be examined, tested for [[urethra]]l or [[cervical]] [[chlamydia]]l infection, and treated with [[doxycycline]], twice daily for 7 days.
*Lyphogranuloma venereum (LGV) may develop after transmission of [[servars]] L1, L2, or L3 of the bacterium ''[[Chlamydia trachomatis]]''.
*''C. trachomatis'' can be transmitted through vaginal, anal, or oral sexual contact.<ref name="pmid25870512">{{cite journal| author=Ceovic R, Gulin SJ| title=Lymphogranuloma venereum: diagnostic and treatment challenges. | journal=Infect Drug Resist | year= 2015 | volume= 8 | issue=  | pages= 39-47 | pmid=25870512 | doi=10.2147/IDR.S57540 | pmc=PMC4381887 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=25870512  }} </ref>
*''C. trachomatis'' is an obligate intracellular pathogen.<ref name="pmid25123797">{{cite journal| author=Datta B, Njau F, Thalmann J, Haller H, Wagner AD| title=Differential infection outcome of Chlamydia trachomatis in human blood monocytes and monocyte-derived dendritic cells. | journal=BMC Microbiol | year= 2014 | volume= 14 | issue=  | pages= 209 | pmid=25123797 | doi=10.1186/s12866-014-0209-3 | pmc=PMC4236547 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=25123797  }} </ref>
 
===Pathogenesis===


The clinical manifestation of LGV depends on the site of entry of the infectious organism (the sex contact site) and the stage of disease progression. Inoculation at the mucous lining of external sex organs (penis and vagina) can lead to the inguinal syndrome named after the formation of buboes or [[abscess]]es in the groin (inguinal) region where draining lymph nodes are located. The rectal syndrome arises if the infection takes place via the rectal mucosa (through anal sex) and is mainly characterized by [[proctocolitis]] symptoms. The pharyngeal syndrome is rare, starts after infection of pharyngeal tissue and buboes in the neck region can occur.


==References==
==References==

Revision as of 15:01, 9 February 2016

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Nate Michalak, B.A.

Overview

Pathophysiology

Lymphogranuloma venereum (LGV) is a chronic (long-term) infection of the lymphatic system caused by three different types of the bacteria Chlamydia trachomatis. The bacteria spread through sexual contact. The infection is caused by a different bacteria than that which causes genital chlamydia.

Transmission

  • Lyphogranuloma venereum (LGV) may develop after transmission of servars L1, L2, or L3 of the bacterium Chlamydia trachomatis.
  • C. trachomatis can be transmitted through vaginal, anal, or oral sexual contact.[1]
  • C. trachomatis is an obligate intracellular pathogen.[2]

Pathogenesis

References

  1. Ceovic R, Gulin SJ (2015). "Lymphogranuloma venereum: diagnostic and treatment challenges". Infect Drug Resist. 8: 39–47. doi:10.2147/IDR.S57540. PMC 4381887. PMID 25870512.
  2. Datta B, Njau F, Thalmann J, Haller H, Wagner AD (2014). "Differential infection outcome of Chlamydia trachomatis in human blood monocytes and monocyte-derived dendritic cells". BMC Microbiol. 14: 209. doi:10.1186/s12866-014-0209-3. PMC 4236547. PMID 25123797.


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